Expression profiles of drug-metabolizing enzymes in liver and plasma: does circulating RNA mirror hepatic protein expression?

Description

Seminar summary: Drug-metabolizing enzymes and drug transporters play an important role in hepatic drug metabolism and disposition and therefore have major implications on the fate of drugs in the human body. Recently, an increasing number of studies have reported expression profiles of pharmacologically relevant enzymes and transporters providing rich data that can be used for simulation and modelling, which serve to inform dosing in the clinic. Stratified dosing followed by precision dosing have emerged recently with the possibility of applying diagnostic expression profiles to guide individual dosing. This talk focuses on initial efforts to leverage precision dosing techniques using plasma as an indicator of expression profiles in liver, the main site of drug metabolism.

Period	4 Nov 2016
Held at	Thermo Fisher Scientific, United States, Texas
Degree of Recognition	International