Proteomic Quantification of Human Blood-Brain Barrier Drug Transporters and Solute Carriers in Healthy Individuals and Dementia Patients

Description

The Blood-Brain Barrier (BBB) maintains brain homeostasis by controlling traffic of molecules from the circulation. This function is predominantly dependent on proteins expressed at the BBB, mainly transporters and tight junction proteins. Alterations to BBB proteins can lead to changes in brain function affecting the susceptibility of the central nervous system to exposure to xenobiotics in the systemic circulation. Recent advances in quantitative proteomics can enable measurement of transporters in the BBB, and therefore can be used to develop pharmacokinetic models for psychoactive drugs.

Period	30 Nov 2018
Event title	8TH Annual UK & Ireland Early Career Blood Brain Barrier Symposium
Event type	Conference
Location	Oxford, United KingdomShow on map
Degree of Recognition	National