Pain threshold rises with altered brain chemistry

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It has been known for a long time that we have receptors in our brains that respond to natural pain killing opiates such as endorphins, but the researchers at the

University of Manchester have now shown that these receptors increase in number to help cope with long-term, severe pain.

The study also explains as to why some people seem to cope better than others with pain.

By applying heat to the skin using a laser stimulator, Christopher Brown and his team showed that more the opiate receptors there are in the brain, the higher the

ability to withstand the pain.

The study used Positron Emission Tomography (PET) imaging on 17 patients with arthritis and nine healthy controls to show the spread of the opioid receptors.

"This is the first time these changes have been associated with increased resilience to pain and shown to be adaptive," Brown said.

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"Although the mechanisms of these adaptive changes are unknown, if we understand how we can enhance them, we may find ways of naturally increasing resilience

to pain without the side effects associated with many pain killing drugs," he added.

Professor Anthony Jones, director of the Manchester Pain Consortium which focuses on improving the understanding and treatment of chronic pain, said, "This is

very exciting because it changes the way we think about chronic pain."

Period25 Oct 2015

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