Title Clinical trials cancer patient hails drug Media name/outlet BBC News Media type Web Country/Territory United Kingdom Date 28/03/22 Description Dr Matthew Krebs, medical oncologist from The Christie Trust and The University of Manchester, said her tumours had since reduced by nearly 50% in three months.
He stated this was "promising for a drug early in its development directed at KRAS mutation that has historically been very difficult to treat".
Dr Krebs added: "It targets only a specific sub-type of KRAS mutation, and a similar drug has already been approved for patients with lung cancer.
"There's much more work to do before this drug may be available routinely for patients, and not everyone will respond in this way, but Terri's case highlights... the potential benefits that clinical trials of new drugs can hold."
URL https://www.bbc.co.uk/news/uk-england-hereford-worcester-60879065 Persons Matthew Krebs Title Cancer-hit gran's tumours shrink in HALF after Christie Hospital drug trial breakthrough Media name/outlet Manchester Evening News Media type Web Country/Territory United Kingdom Date 28/03/22 Description Dr Matthew Krebs, medical oncologist from the Christie and the University of Manchester, leading on the study in the UK, said: "We are delighted at the response Terri has had to this treatment. Her scans show that her tumours have reduced by nearly 50% in just three months.
“There’s much more work to do before this drug may be available routinely for patients, and not everyone will respond in this way, but Terri’s case highlights the importance of genetic testing in cancer patients and the potential benefits that clinical trials of new drugs can hold."
Dr Krebs said the KRAS mutation is one of the most common mutations across a range of cancer types. The specific sub-type in Ms Hurdman’s case is KRAS G12C – the most common subgroup – which occurs in about 12% to 15% of lung cancers and 3% to 4% of bowel cancers. Around 47,000 people are diagnosed with lung cancer in the UK every year, while 43,000 are diagnosed with bowel cancer.
URL https://www.manchestereveningnews.co.uk/news/greater-manchester-news/cancer-hit-grans-tumours-shrink-23514541 Persons Matthew Krebs
Research Beacons, Institutes and Platforms
- bowel cancer