Description
Figure S11. The first stage QueF mechanism of action showing cysteine deprotonation and thioamide bond formation. Figure S12. First hydride transfer from NADPH to the central carbon. Figure S13. Thioamide bond cleavage and acid reprotonation. Figure S14. Final hydride transfer from NADPH to the substrate.
| Date made available | 31 Aug 2022 |
|---|---|
| Publisher | University of Manchester Figshare |
Keywords
- density functional theory
- DFT
- catalytic cycle
- nitrile reductase
- benzyl cyanide
- preQ0
- QueF