HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer

  • Andrew E. Teschendorff (Creator)
  • Shih Han Lee (Creator)
  • Allison Jones (Creator)
  • Heidi Fiegl (Creator)
  • Marie Kalwa (Creator)
  • Wolfgang Wagner (Creator)
  • Kantaraja Chindera (Creator)
  • Iona Evans (Creator)
  • Louis Dubeau (Creator)
  • Arturo Orjalo (Creator)
  • Hugo M. Horlings (Creator)
  • Lukas Niederreiter (Creator)
  • Arthur Kaser (Creator)
  • Winnie Yang (Creator)
  • Ellen L Goode (Creator)
  • Brooke L Fridley (Creator)
  • Richard G. Jenner (Creator)
  • Els Berns (Creator)
  • Elisabeth Wik (Creator)
  • Helga B Salvesen (Creator)
  • G. Wisman (Creator)
  • Ate G J Van Der Zee (Creator)
  • Ben Davidson (Creator)
  • Claes G. Trope (Creator)
  • Sandrina Lambrechts (Creator)
  • Ignace Vergote (Creator)
  • Hilary Calvert (Creator)
  • Ian Jacobs (Creator)
  • Martin Widschwendter (Creator)

Dataset

Description

Abstract Background Understanding carboplatin resistance in ovarian cancer is critical for the improvement of patients’ lives. Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of a cancer are integrally involved in pathways conferring chemo-resistance. Long non-coding RNA HOTAIR (HOX transcript antisense intergenic RNA) is involved in mesenchymal stem cell fate and cancer biology. Methods We analyzed HOTAIR expression and associated surrogate DNA methylation (DNAme) in 134 primary ovarian cancer cases (63 received carboplatin, 55 received cisplatin and 16 no chemotherapy). We validated our findings by HOTAIR expression and DNAme analysis in a multicentre setting of five additional sets, encompassing 946 ovarian cancers. Chemo-sensitivity has been assessed in cell culture experiments. Results HOTAIR expression was significantly associated with poor survival in carboplatin-treated patients with adjusted hazard ratios for death of 3.64 (95 % confidence interval [CI] 1.78–7.42; P 
Date made available24 Oct 2015
Publisherfigshare

Keywords

  • Long non-coding RNA HOTAIR
  • HOTAIR expression
  • cancer Abstract Background
  • DNA methlyation signature
  • cell culture experiments
  • CI
  • HOX transcript antisense intergenic RNA
  • carboplatin resistance
  • DNAme
  • Results HOTAIR expression
  • mesenchymal transition phenotype

  • HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer

    Teschendorff, A. E., Lee, S.-H., Jones, A., Fiegl, H., Kalwa, M., Wagner, W., Chindera, K., Evans, I., Dubeau, L., Orjalo, A., Horlings, H. M., Niederreiter, L., Kaser, A., Yang, W., Goode, E. L., Fridley, B. L., Jenner, R. G., Berns, E. M. J. J., Wik, E. & Salvesen, H. B. & 9 others, Wisman, G. B. A., Van Der Zee, A. G. J., Davidson, B., Trope, C. G., Lambrechts, S., Vergote, I., Calvert, H., Jacobs, I. J. & Widschwendter, M., 1 Dec 2015, In: Genome Medicine. 7, 1

    Research output: Contribution to journal › Article › peer-review

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