The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix

  • Jeremy Herrera (Creator)
  • Lewis Dingle (Creator)
  • M. Montero (Creator)
  • RV Venkateswaran (Creator)
  • John Blaikley (Creator)
  • Craig Lawless (Creator)
  • Martin Schwartz (Creator)

Dataset

Description

The Fibroblastic Focus (FF) is a lesion typical of Idiopathic Pulmonary Fibrosis (IPF). It is the site of myofibroblast accumulation and extracellular matrix (ECM) production. The molecular composition and function of the FF and surrounding tissue remain undefined. Utilizing laser capture microdissection coupled mass spectrometry (LCM-MS), we interrogate the FF, adjacent mature scar tissue, and adjacent alveoli in 6 IPF specimens. To serve as a control, we perform LCM-MS on alveoli from 6 non-fibrotic controls.
Date made available31 Aug 2022
PublisherPRoteomics IDEntifications Database
Date of data production31 Aug 2022

Keywords

  • human
  • fibroblastic focus
  • collagen
  • IPF

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