Research output per year
Research output per year
- 1 - 50 out of 74 results
Search results
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2023
arfA antisense RNA regulates MscL excretory activity
Morra, R., Pratama, F., Butterfield, T., Tomazetto, G., Young, K., Lopez, R. & Dixon, N., 3 Apr 2023, (E-pub ahead of print) In: Life Science Alliance.Research output: Contribution to journal › Article › peer-review
Open Access -
How is substrate halogenation triggered by the vanadium haloperoxidase from Curvularia inaequalis?
Gerard, E., Mokkawes, T., Johannissen, L., Warwicker, J., Spiess, R., Blanford, C. F., Hay, S., Heyes, D. & De Visser, S., 6 Jun 2023, In: ACS Catalysis. 13, 12Research output: Contribution to journal › Article › peer-review
Open Access -
Microbial communities in freshwater used for hydraulic fracturing are unable to withstand the high temperatures and pressures characteristic of fractured shales
Nixon, S., Plominsky, A. M., Hernandez Becerra, N., Boothman, C. & Bartlett, D. H., 21 Apr 2023, In: Access Microbiology. 5, 4Research output: Contribution to journal › Article › peer-review
Open Access -
New microbiological insights from the Bowland shale highlight heterogeneity of the hydraulically fractured shale microbiome
Hernandez Becerra, N., Cliffe, L., Xiu, W., Boothman, C., Lloyd, J. & Nixon, S., 11 Jan 2023, (Accepted/In press) In: Environmental Microbiome.Research output: Contribution to journal › Article › peer-review
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Photoinduced Electron Transfer from a 1,4,5,6-Tetrahydro Nicotinamide Adenine Dinucleotide (Phosphate) Analog to Oxidized Flavin in an Ene-Reductase Flavoenzyme
Speirs, M., Hardman, S., Iorgu, A. I., Johannissen, L., Heyes, D., Scrutton, N., Sazanovich, I. V. & Hay, S., 6 Apr 2023, In: Journal of Physical Chemistry Letters. 14, 13, p. 3236-3242Research output: Contribution to journal › Article › peer-review
Open Access -
Redox driven B12-ligand switch drives CarH photoresponse
Poddar, H., Rios-Santacruz, R., Heyes, D. J., Shanmugam, M., Brookfield, A., Johannissen, L. O., Levy, C. W., Jeffreys, L. N., Zhang, S., Sakuma, M., Colletier, J. P., Hay, S., Schirò, G., Weik, M., Scrutton, N. S. & Leys, D., Dec 2023, In: Nature Communications. 14, 1, 5082.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
A Designed Photoenzyme for Enantioselective [2+2]-Cycloadditions
Trimble, J., Crawshaw, R., Hardy, F., Levy, C., Brown, M. J. B., Fuerst, D. E., Heyes, D., Obexer, R. & Green, A., 21 Sept 2022, In: Nature.. 611, 7937Research output: Contribution to journal › Article › peer-review
Open AccessFile101 Downloads (Pure) -
A guide to time-resolved structural analysis of light-activated proteins
Poddar, H., Heyes, D., Schirò, G., Weik , M., Leys, D. & Scrutton, N., 1 Feb 2022, In: The FEBS Journal. 289, 3, p. 576-595 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Bioproduction of Linalool From Paper Mill Waste
Rinaldi, M. A., Tait, S., Toogood, H. S. & Scrutton, N. S., 30 May 2022, In: Frontiers in Bioengineering and Biotechnology. 10, p. 892896 892896.Research output: Contribution to journal › Article › peer-review
Open Access -
Geochemistry and microbiology of tropical serpentine soils in the Santa Elena Ophiolite, a landscape-biogeographical approach
Solano-Arguedas, A. F., Boothman, C., Newsome, L., Pattrick, R. A. D., Arguedas-Quesada, D., Robinson, C. H. & Lloyd, J. R., 27 Sept 2022, (E-pub ahead of print) In: Geochemical Transactions. 23, 1, 2.Research output: Contribution to journal › Article › peer-review
Open Access -
Guar Gum Stimulates Biogenic Sulfide Production in Microbial Communities Derived from UK Fractured Shale Production Fluids
Cliffe, L., Hernandez-Becerra, N., Boothman, C., Eden, B., Lloyd, J. R. & Nixon, S. L., 1 Dec 2022, In: Microbiology spectrum. 10, 6Research output: Contribution to journal › Article › peer-review
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How Photoactivation Triggers Protochlorophyllide Reduction: Computational Evidence of a Stepwise Hydride Transfer During Chlorophyll Biosynthesis
Johannissen, L., Taylor, A., Hardman, S., Heyes, D., Scrutton, N. & Hay, S., 8 Mar 2022, (Accepted/In press) In: ACS Catalysis.Research output: Contribution to journal › Article › peer-review
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Retention of immobile Se(0) in flow-through aquifer column systems during bioreduction and oxic-remobilization
Ho, M. S., Vettese, G. F., Morris, K., Lloyd, J. R., Boothman, C., Bower, W. R., Shaw, S. & Law, G. T. W., 15 Aug 2022, In: Science of the Total Environment. 834, 155332.Research output: Contribution to journal › Article › peer-review
Open Access -
Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases
Rose, S. L., Baba, S., Okumura, H., Antonyuk, S. V., Sasaki, D., Hedison, T. M., Shanmugam, M., Heyes, D. J., Scrutton, N. S., Kumasaka, T., Tosha, T., Eady, R. R., Yamamoto, M. & Hasnain, S. S., 26 Jul 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 30, e2205664119.Research output: Contribution to journal › Article › peer-review
Open Access -
Solution-State Inter-Copper Distribution of Redox Partner-Linked Copper Nitrite Reductases: A Pulsed Electron–Electron Double Resonance Spectroscopy Study
Hedison, T. M., Iorgu, A. I., Calabrese, D., Heyes, D. J., Shanmugam, M. & Scrutton, N. S., 22 Jul 2022, In: The journal of physical chemistry letters. p. 6927-6934Research output: Contribution to journal › Article › peer-review
Open Access -
2021
An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir
Burke, A., Birmingham, W., Zhuo, Y., Thorpe, T., Zucoloto Da Costa, B., Crawshaw, R., Rowles, I., Finnigan, J. D., Young, C., Holgate, G. M., Muldowney, M. P., Charnock, S. J., Lovelock, S., Turner, N. & Green, A., 17 Dec 2021, (Accepted/In press) In: Journal of the American Chemical Society.Research output: Contribution to journal › Article › peer-review
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A Noncanonical Tryptophan Analogue Reveals an Active Site Hydrogen Bond Controlling Ferryl Reactivity in a Heme Peroxidase
Ortmayer, M., Hardy, F. J., Quesne, M. G., Fisher, K., Levy, C., Heyes, D. J., Catlow, C. R. A., Visser, S. P. D., Rigby, S. E. J., Hay, S. & Green, A. P., 26 Jul 2021, In: JACS Au.Research output: Contribution to journal › Article › peer-review
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A plasmid toolset for CRISPR-mediated genome editing and CRISPRi gene regulation in Escherichia coli
Jervis, A., Hanko, E., Dunstan, M., Robinson, C., Takano, E. & Scrutton, N., 12 Mar 2021, In: Microbial Biotechnology.Research output: Contribution to journal › Article › peer-review
Open Access -
Biogenic sulfidation of U(VI) and ferrihydrite mediated by sulfate-reducing bacteria at elevated pH
Townsend, L., Kuippers, G., Lloyd, J., Natrajan, L., Boothman, C., Mosselmans, J. F. W., Shaw, S. & Morris, K., 17 Aug 2021, (Accepted/In press) In: ACS Earth and Space Chemistry.Research output: Contribution to journal › Article › peer-review
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Biogeochemical Cycling of 99Tc in Alkaline Sediments
Williamson, A., Lloyd, J., Boothman, C., Law, G., Shaw, S., Small, J. S., Vettese, G. F., Williams, H. & Morris, K., 12 Nov 2021, (Accepted/In press) In: Environmental Science & Technology.Research output: Contribution to journal › Article › peer-review
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Engineering an Efficient and Enantioselective Enzyme for the Morita-Baylis-Hillman Reaction
Crawshaw, R., Crossley, A., Johannissen, L., Burke, A., Hay, S., Levy, C., Baker, D., Lovelock, S. & Green, A., 16 Dec 2021, In: Nature Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile62 Downloads (Pure) -
Interplay Between Chromophore-Binding and Domain Assembly by the B12-Dependent Photoreceptor Protein, CarH
Camacho, I., Black, R., Heyes, D., Johannissen, L. O., Ramakers, L. A. I., Bellina, B., Barran, P., Hay, S. & Jones, A. R., 5 May 2021, In: Chemical Science.Research output: Contribution to journal › Article › peer-review
Open Access -
Microbial degradation of citric acid in low level radioactive waste disposal: impact on biomineralisation reactions
Byrd, N., Lloyd, J., Small, J., Taylor, F., Bagshaw, H., Boothman, C. & Morris, K., 28 Apr 2021, In: Frontiers in Microbiology.Research output: Contribution to journal › Article › peer-review
Open Access -
Prototyping of microbial chassis for the biomanufacturing of high-value chemical targets
Robinson, C. J., Tellechea-luzardo, J., Carbonell, P., Jervis, A. J., Yan, C., Hollywood, K. A., Dunstan, M. S., Currin, A., Takano, E. & Scrutton, N. S., 8 Jun 2021, In: Biochemical Society Transactions.Research output: Contribution to journal › Article › peer-review
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2020
Active Intermediates in Copper Nitrite Reductase Reactions Probed by a Cryotrapping‐Electron Paramagnetic Resonance Approach
Hedison, T. M., Shanmugam, M., Heyes, D. J., Edge, R. & Scrutton, N., 30 Apr 2020, (E-pub ahead of print) In: Angewandte Chemie International Edition.Research output: Contribution to journal › Article › peer-review
Open Access -
Advantages of brain penetrating inhibitors of kynurenine-3-monooxygenase for treatment of neurodegenerative diseases
Zhang, S., Collier, M. E. W., Heyes, D., Giorgini, F. & Scrutton, N., 1 Dec 2020, (E-pub ahead of print) In: Archives of Biochemistry and Biophysics.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Downloads (Pure) -
A Novel “Microbial Bait” Technique for Capturing Fe(III)-Reducing Bacteria
Macaulay, B. M., Boothman, C., van Dongen, B. E. & Lloyd, J. R., 11 Mar 2020, In: Frontiers in Microbiology.Research output: Contribution to journal › Article › peer-review
Open Access -
Dual Role of the Active Site ‘Lid’ Regions of Protochlorophyllide Oxidoreductase in Photocatalysis and Plant Development
Zhang, S., Godwin, A., Taylor, A., Hardman, S., Jowitt, T., Johannissen, L., Hay, S., Baldock, C., Heyes, D. & Scrutton, N., 31 Aug 2020, (E-pub ahead of print) In: The FEBS Journal.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineering Escherichia coli towards de novo production of gatekeeper (2S)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol.
Dunstan, M., Robinson, C., Jervis, A., Yan, C., Carbonell, P., Hollywood, K., Currin, A., Swainston, N., Le Feuvre, R., Micklefield, J., Faulon, J.-L., Breitling, R., Turner, N., Takano, E. & Scrutton, N., 6 Aug 2020, In: Synthetic Biology . 5, 1, ysaa012.Research output: Contribution to journal › Article › peer-review
Open Access -
Ferulic Acid Decarboxylase Controls Oxidative Maturation of the Prenylated Flavin Mononucleotide Cofactor
Balaikaite, A., Chisanga, M., Fisher, K., Heyes, D. J., Spiess, R. & Leys, D., 18 Sept 2020, In: ACS chemical biology. 15, 9, p. 2466-2475 10 p.Research output: Contribution to journal › Article › peer-review
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Identification of a stable hydrogendriven microbiome in highly radioactive storage facilities in Sellafield, UK
Ruiz Lopez, S., Foster, L., Boothman, C., Cole, N., Morris, K. & Lloyd, J., 24 Nov 2020, (E-pub ahead of print) In: Frontiers in Microbiology.Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of persistent sulfidogenic bacteria in shale gas produced waters
Cliffe, L., Nixon, S., Daly, R., Taylor, K., Eden, B., Boothman, C., Wilkins, M. J., Wrighton, K. C. & Lloyd, J., 21 Feb 2020, In: Frontiers in Microbiology.Research output: Contribution to journal › Article › peer-review
Open Access -
Insights into the H2O2 ‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases
Hedison, T. M., Breslmayr, E., Shanmugam, M., Karnpakdee, K., Heyes, D. J., Green, A. P., Ludwig, R., Scrutton, N. S. & Kracher, D., 23 Dec 2020, In: The FEBS Journal.Research output: Contribution to journal › Article › peer-review
Open Access -
Microbial bloom formation in a high pH spent nuclear fuel pond
Foster, L., Boothman, C., Ruiz-lopez, S., Boshoff, G., Jenkinson, P., Sigee, D., Pittman, J. K., Morris, K. & Lloyd, J. R., Feb 2020, In: Science of the Total Environment. p. 137515Research output: Contribution to journal › Article › peer-review
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Photochemical mechanism of light-driven fatty acid photodecarboxylase
Heyes, D. J., Lakavath, B., Hardman, S. J. O., Sakuma, M., Hedison, T. M. & Scrutton, N. S., 19 Jun 2020, In: ACS Catalysis. 10, 12, p. 6691-6696 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Photocycle of cyanobacteriochrome TePixJ
Hardman, S. J. O., Heyes, D. J., Sazanovich, I. V. & Scrutton, N. S., 18 Aug 2020, In: Biochemistry. 59, 32, p. 2909-2915 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Promoter Engineering for Microbial Bio-alkane Gas Production
Trisrivirat, D., Hughes, J., Hoeven, R., Faulkner, M., Toogood, H., Chaiyen, P. & Scrutton, N., 27 Oct 2020, (E-pub ahead of print) In: Synthetic Biology . 5, 1Research output: Contribution to journal › Article › peer-review
Open Access -
Protein Conformational Change Is Essential for Reductive Activation of Lytic Polysaccharide Monooxygenase by Cellobiose Dehydrogenase
Breslmayr, E., Laurent, C. V. F. P., Scheiblbrandner, S., Jerkovic, A., Heyes, D. J., Oostenbrink, C., Ludwig, R., Hedison, T. M., Scrutton, N. S. & Kracher, D., 9 Apr 2020, In: ACS Catalysis. p. 4842-4853Research output: Contribution to journal › Article › peer-review
Open Access -
Radiation tolerance of Pseudanabaena catenata, a cyanobacterium relevant to the First Generation Magnox Storage Pond
Foster, L., Muhamadali, H., Boothman, C., Sigee, D., Pittman, J., Goodacre, R., Morris, K. & Lloyd, J., 7 Apr 2020, In: Frontiers in Microbiology. 11, 515.Research output: Contribution to journal › Article › peer-review
Open Access -
Radical-based photoinactivation of fatty acid photodecarboxylases
Lakavath, B., Hedison, T., Heyes, D., Shanmugam, M., Sakuma, M., Hoeven, R., Tilakaratna, V. & Scrutton, N., 26 Apr 2020, In: Analytical Biochemistry|Anal Biochem. 600, 113749.Research output: Contribution to journal › Article › peer-review
Open Access -
Rapid prototyping of microbial production strains for the biomanufacture of potential material monomers
Robinson, C., Carbonell, P., Jervis, A., Yan, C., Hollywood, K., Currin, A., Swainston, N., Speiss, R., Taylor, S., Mulherin, P., Parker, S., Rowe, W., Matthews, N., Malone, K., Le Feuvre, R., Shapira, P., Barran, P., Turner, N., Micklefield, J. & Breitling, R. & 2 others, , 1 Jul 2020, In: Metabolic Engineering.Research output: Contribution to journal › Article › peer-review
Open AccessFile214 Downloads (Pure) -
Renewable and Tuneable Bio-LPG Blends Derived from Amino Acids
Amer, M., Hoeven, R., Kelly, P., Faulkner, M., Smith, M. H., Toogood, H. & Scrutton, N., 14 Jul 2020, In: Biotechnology for Biofuels.Research output: Contribution to journal › Article › peer-review
Open Access -
Rewiring the ‘Push-Pull’ Catalytic Machinery of a Heme Enzyme using an Expanded Genetic Code
Ortmayer, M., Fisher, K., Basran, J., Wolde-Michael, E. M., Heyes, D. J., Levy, C., Lovelock, S. L., Anderson, J. L. R., Raven, E. L., Hay, S., Rigby, S. E. J. & Green, A. P., 2020, In: ACS Catalysis. 10, 4, p. 2735-2746 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile105 Downloads (Pure) -
Ribosomal Protein L11 Selectively Stabilizes a Tertiary Structure of the GTPase Center rRNA Domain
Welty, R., Rau, M., Pabit, S., Dunstan, M. S., Conn, G. L., Pollack, L. & Hall, K. B., 14 Feb 2020, In: Journal of molecular biology. 432, 4, p. 991-1007 17 p.Research output: Contribution to journal › Article › peer-review
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The catalytic mechanism of aromatic nitration by cytochrome P450 TxtE: Involvement of a ferric-peroxynitrite intermediate
Louka, S., Barry, S. M., Heyes, D. J., Mubarak, M. Q. E., Ali, H. S., Alkhalaf, L., Munro, A. W., Scrutton, N. S., Challis, G. L. & De Visser, S. P., 19 Aug 2020, (E-pub ahead of print) In: Journal of the American Chemical Society.Research output: Contribution to journal › Article › peer-review
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Ultrafast Vibrational Energy Transfer between Protein and Cofactor in a Flavoenzyme
Hardman, S. J. O., Iorgu, A. I., Heyes, D. J., Scrutton, N. S., Sazanovich, I. V. & Hay, S., 4 Jun 2020, (E-pub ahead of print) In: The Journal of Physical Chemistry B.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites
Zhang, S., Sakuma, M., Deora, G. S., Levy, C., Klausing, A., Breda, C., Read, K. D., Ross, B. P., Wright Muelas, M., Day, P., O'Hagan, S., Kell, D., Schwarcz, R., Leys, D., Heyes, D., Giorgini, F. & Scrutton, N., 2019, In: Communications Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Design and evolution of an enzyme with a non-canonical organocatalytic mechanism
Burke, A. J., Lovelock, S. L., Frese, A., Crawshaw, R., Ortmayer, M., Dunstan, M., Levy, C. & Green, A. P., 27 May 2019, In: Nature. 570, p. 219-223Research output: Contribution to journal › Article › peer-review
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Enzymatic Carboxylation of 2-Furoic Acid Yields 2,5-Furandicarboxylic Acid (FDCA)
Payne, K. A. P., Marshall, S., Fisher, K., Cliff, M. J., Cannas, D., Yan, C., Heyes, D. J., Parker, D., Larrosa, I. & Leys, D., 15 Feb 2019, In: ACS Catalysis. 9, 4, p. 2854-2865 12 p.Research output: Contribution to journal › Article › peer-review
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Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries
Currin, A., Swainston, N., Dunstan, M., Jervis, A., Mulherin, P., Robinson, C., Taylor, S., Carbonell, P., Hollywood, K., Yan, C., Takano, E., Scrutton, N. & Breitling, R., 29 Oct 2019, In: Synthetic Biology .Research output: Contribution to journal › Article › peer-review
Open Access