Narrative
Measurement of hormones is essential to the understanding and diagnosis of endocrine diseases. White and her research group have developed unique antibodies that are widely used in diagnostic assays for adrenocorticotrophic hormone (ACTH) and related peptides, including the first and only kit for measuring pro-opiomelanocortin (POMC), the precursor of ACTH. These assays are used worldwide for diagnosis, decisions on treatment, monitoring for recurrence of tumours and prognosis in a number of patient groups with life-threatening endocrine disorders. Global sales of the ACTH Elecsys tests by Roche exceeded 6 million kits since 2008. AstraZeneca has used the POMC and ACTH assays in its drug discovery programmes in the cardiovascular and metabolic diseases therapy area. The antibodies therefore have had health impact in relieving suffering and in improving patient care, as well as commercial impact in worldwide sales of assays and influencing drug development strategies.Impact date | 2014 |
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Category of impact | Economic impacts, Health impacts, Societal impacts, Technological impacts |
Impact level | Benefit |
Documents & Links
Related content
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Research output
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Cushing's syndrome due to phaeochromocytoma secreting the precursors of adrenocorticotropin
Research output: Contribution to journal › Article › peer-review
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A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism
Research output: Contribution to journal › Article › peer-review
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ACTH precursors characterize the ectopic ACTH syndrome
Research output: Contribution to journal › Article › peer-review
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Proopiomelanocortin-derived peptides in rat cerebrospinal fluid and hypothalamic extracts: Evidence that secretion is regulated with respect to energy balance
Research output: Contribution to journal › Article › peer-review
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Differential release of proopiomelanocortin-derived peptides from the human pituitary: evidence from a panel of two-site immunoradiometric assays
Research output: Contribution to journal › Article › peer-review
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Rapid glucocorticoid receptor-mediated inhibition of hypothalamic- pituitary-adrenal ultradian activity in healthy males
Research output: Contribution to journal › Article › peer-review