Narrative
Researchers at The University of Manchester invented technology that expedites drug discovery by measuring the bioactive shapes of small molecules with unprecedented accuracy using nuclear magnetic resonance. The technology, assigned to spin-out C4XDiscovery, was used to successfully initiate several novel drug programmes, which led to the company raising GBP31,000,000 via a flotation on the London Stock Exchange. Its lead programme aims to treat addiction across a broad range of substance use disorders, which is an area of unmet need costing the US USD1,000,000,000,000 annually, by targeting the craving process itself. The technology delivered drug candidates for this programme in a fraction of the time compared with traditional pharmaceutical methodologies, with substantially lower toxicity and side-effects and saving 90% of the typical USD1,000,000,000 pre-clinical cost. The programme entered clinical development in 2018 via a USD294,000,000 licencing deal with Indivior PLC.Impact date | 1 Aug 2013 → 31 Jul 2020 |
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Category of impact | Economic, Technological |
Impact level | Adoption |
Research Beacons, Institutes and Platforms
- Biotechnology
Documents & Links
- REF2021 impact case- C4X Discovery: generating market-leading drug candidates from cutting-edge technology
File: application/pdf, 409 KB
Type: Text
Related content
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Research output
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Dynamics of hyaluronan oligosaccharides revealed by 15N relaxation
Research output: Contribution to journal › Article › peer-review
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Hyaluronan: The Local Solution Conformation Determined by NMR and Computer Modeling is Close to a Contracted Left-handed 4-Fold Helix
Research output: Contribution to journal › Article › peer-review
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Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation
Research output: Contribution to journal › Article › peer-review
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Hyaluronan: The absence of amide-carboxylate hydrogen bonds and the chain conformation in aqueous solution are incompatible with stable secondary and tertiary structure models
Research output: Contribution to journal › Article › peer-review
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Method for determining three-dimensional structures of dynamic molecules
Research output: Patent
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Impacts
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Opening the door to ligand-based drug discovery: a rapid and accurate technology for determining bioactive 3D molecular shapes
Impact: Economic impacts, Health impacts, Technological impacts