Narrative
The University of Manchester (UoM) has led internationally in describing the methodology, mechanisms and implications of azole resistance in Aspergillus, a common airborne fungus causing life-threatening lung diseases called aspergillosis. Such resistance is a major clinical problem because the best (and only oral) antifungal drugs are azoles. The UoM team’s research has led to the following impacts: i) developed and validated a standardised antifungal susceptibility testing method, now a global reference method, ii) enabled documentation of resistance in every continent, iii) driven new antifungal drug development (>USD300,000,000 investment) and iv) spawned one commercial product detecting resistance, sold in >25 countries.Impact date | 1 Aug 2013 → 31 Jul 2020 |
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Category of impact | Health and wellbeing, Policy, Economic |
Impact level | Adoption |
Research Beacons, Institutes and Platforms
- Lydia Becker Institute
Documents & Links
Related content
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Research output
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Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure
Research output: Contribution to journal › Article › peer-review
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High-frequency triazole resistance found in nonculturable aspergillus fumigatus from lungs of patients with chronic fungal disease
Research output: Contribution to journal › Article › peer-review
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EUCAST technical note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia-forming moulds
Research output: Contribution to journal › Article › peer-review
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Azole cross-resistance in Aspergillus fumigatus
Research output: Contribution to journal › Article › peer-review
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Impacts
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Transforming patient outcome of pulmonary aspergillosis with better and faster diagnosis and therapy
Impact: Health and wellbeing, Economic
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Diagnostics and novel life-saving therapies for aspergillosis
Impact: Health impacts
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Successfully tackling serious fungal diseases to transform global population health
Impact: Health and wellbeing