Narrative
Extensible fibrillin-rich microfibrils are the template for elastic fibres that endow dynamic tissues with elastic recoil. Researchers at the University of Manchester (UoM) showed that microfibrils are degraded in photoaged skin. We developed a rapid in vivo assay, ‘The Manchester Patch Test Assay’, which predicts the potential of anti-ageing products to restore microfibrils in photoaged skin. The assay was used to demonstrate the efficacy of a Boots Healthcare anti-ageing product and was showcased on the BBC’s Horizon in 2007. Impacts include: dramatically increased sales for Boots, investment and changes to the product development strategies of more than 10 international personal care companies, which have used our assay to support product claims.| Impact date | 2014 |
|---|---|
| Category of impact | Health impacts |
| Impact level | Benefit |
Related content
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Research output
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Salicyloyl-phytosphingosine: A novel agent for the repair of photoaged skin
Research output: Contribution to journal › Article › peer-review
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A short-term screening protocol, using fibrillin-1 as a reporter molecule, for photoaging repair agents
Research output: Contribution to journal › Article › peer-review
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In vitro and in vivo studies with tetra-hydro-jasmonic acid (LR2412) reveal its potential to correct signs of skin ageing
Research output: Contribution to journal › Article › peer-review
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Repair of photoaged dermal matrix by topical application of a cosmetic 'antiageing' product
Research output: Contribution to journal › Article › peer-review
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Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction
Research output: Contribution to journal › Article › peer-review