Narrative
A critical step in drug discovery is accurate determination of bioactive 3-dimensional structures of biologically-relevant molecules. Almond and Blundell’s proprietary method for analysing Nuclear Magnetic Resonance (NMR) data has led to a world-first capability and establishment of the company Conformetrix (renamed C4X Discovery in 2013). The platform technology ('MolGyrate') is used to determine the dynamic 3-dimensional-conformation of biologically relevant molecules directly from NMR data within weeks, compared with months to years for traditional methods. C4X Discovery has secured substantial private investment (the company has not disclosed the amount). In 2012 AstraZeneca began to apply the technology across their entire pre-clinical therapeutic pipeline to enhance lead discovery and hit identification.Impact date | 2014 |
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Category of impact | Economic impacts, Health impacts, Technological impacts |
Impact level | Benefit |
Documents & Links
Related content
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Impacts
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C4X Discovery: generating market-leading drug candidates from cutting-edge technology
Impact: Economic, Technological
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Research output
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Complete assignment of hyaluronan oligosaccharides up to hexasaccharides
Research output: Contribution to journal › Article › peer-review
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Hyaluronan: The absence of amide-carboxylate hydrogen bonds and the chain conformation in aqueous solution are incompatible with stable secondary and tertiary structure models
Research output: Contribution to journal › Article › peer-review
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Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformation
Research output: Contribution to journal › Article › peer-review
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Hyaluronan: The Local Solution Conformation Determined by NMR and Computer Modeling is Close to a Contracted Left-handed 4-Fold Helix
Research output: Contribution to journal › Article › peer-review
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Enzymatic and chemical methods for the generation of pure hyaluronan oligosaccharides with both odd and even numbers of monosaccharide units
Research output: Contribution to journal › Article › peer-review
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Dynamics of hyaluronan oligosaccharides revealed by 15N relaxation
Research output: Contribution to journal › Article › peer-review