Public summary
We developed and validated three new methods to obviate the need for inpatient investigation of chest pain, a common reason for emergency hospital admission. Our research involving >4,000 patients, led to improved diagnostic technologies. Two applications of high-sensitivity cardiac troponin assays are now incorporated in the National Institute for Health and Care Excellence (NICE), and European Society of Cardiology guidelines. A third, the Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid is being implemented across Greater Manchester allowing quicker, more effective diagnosis and treatment. It has been used for >30,000 patients, leading to reduced hospital admissions and savings of approximately GBP2,000 per patient. Our research has supported roll-out of high-sensitivity cardiac troponin testing in England, Wales and the United States.| Impact date | 1 Jan 2016 → 31 Dec 2020 |
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| Category of impact | Health and wellbeing, Economic, Policy |
| Impact level | Adoption |
Documents & Links
Related content
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Research output
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Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid: single biomarker re-derivation and external validation in three cohorts
Research output: Contribution to journal › Article › peer-review
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Diagnostic accuracy of the T-MACS decision aid with a contemporary point-of-care troponin assay
Research output: Contribution to journal › Article › peer-review
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Multicenter Evaluation of a 0-Hour/1-Hour Algorithm in the Diagnosis of Myocardial Infarction With High-Sensitivity Cardiac Troponin T
Research output: Contribution to journal › Article › peer-review
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High-sensitivity cardiac troponin t concentrations below the limit of detection to exclude acute myocardial infarction: a prospective evaluation
Research output: Contribution to journal › Article › peer-review
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The Use of Very Low Concentrations of High-sensitivity Troponin T to Rule Out Acute Myocardial Infarction Using a Single Blood Test
Research output: Contribution to journal › Article › peer-review
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Rapid exclusion of acute myocardial infarction in patients with undetectable troponin using a high-sensitivity assay
Research output: Contribution to journal › Article › peer-review