Supporting Nanobiotix development of NBTXR3, the world’s first nanomedicine to reach market.

Impact: Health and wellbeing


Currell’s local effect modelling approach showed a deep analogy between mechanisms of heavy-ion and nanoparticle enhanced therapy, providing a simple framework to predict the physical component of dose enhancement due to nanoparticles [1] which we have extended to provide the first account for clinically relevant clusters of nanoparticles [2]. The de-facto standard for predicting the efficacy of nanoparticles irradiated in tumours, with many publications using the method or variants of it, it allows computational prediction of efficacy of radiation nanomedicines.

1.Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles, Nature Scientific Reports, 1, 18; DOI:10.1038/srep00018 (2011).
2.Physical Radiation Enhancement Effects Around Clinically Relevant Clusters of Nanoagents in Biological Systems, Nature Scientific Reports, 9, 8156 DOI: 10.1038/s41598-019-44482-y
Impact date20 Jun 201128 Jan 2020
Category of impactHealth and wellbeing

Research Beacons, Institutes and Platforms

  • Dalton Nuclear Institute