Narrative
Extensible fibrillin-rich microfibrils support elastic fibres that endow tissues with elastic recoil. We showed that microfibrils are degraded in photodamaged skin, causing loss of elasticity and wrinkling. We developed a rapid in vivo assay, ‘The Manchester Patch Test Assay’, which predicts the potential of anti-ageing products to restore microfibrils in photoaged skin. The assay was used to demonstrate the efficacy of a Boots Healthcare anti-ageing product, showcased on BBC Horizon in 2007. Impacts include: dramatically increased sales for Boots, investment and changes to product development strategies of international personal care companies, who now use ‘The Manchester Patch Test Assay’ to support product claims| Impact date | 2014 |
|---|---|
| Category of impact | Health impacts, Economic impacts |
| Impact level | Adoption |
Related content
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Research output
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Calcium determines the supramolecular organization of fibrillin-rich microfibrils
Research output: Contribution to journal › Article › peer-review
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The supramolecular organization of fibrillin-rich microfibrils
Research output: Contribution to journal › Article › peer-review
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Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction
Research output: Contribution to journal › Article › peer-review
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Effects of a cosmetic 'anti-ageing' product improves photoaged skin [corrected]: a double‐blind, randomized controlled trial
Research output: Contribution to journal › Article › peer-review
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A short-term screening protocol, using fibrillin-1 as a reporter molecule, for photoaging repair agents
Research output: Contribution to journal › Article › peer-review
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Fibrillin degradation by matrix metalloproteinases: Implications for connective tissue remodelling
Research output: Contribution to journal › Article › peer-review