Chemical Biology and Biological Chemistry

Mohamed Amer El-Gazar
- Chemical Biology and Biological Chemistry - Research Fellow
Person: Academic
Rainer Breitling, DrRerNat
- Chemical Biology and Biological Chemistry - Honorary Professor
Person: Academic
Patrick Cai
- Chemical Biology and Biological Chemistry - Chair in Synthetic Genomics
Person: Academic
Jack Connolly
- Chemical Biology and Biological Chemistry - Research Fellow (Actinomycete)
Person: Academic
Neil Dixon
- Chemical Biology and Biological Chemistry - Reader Sustainable Biotechnology
Person: Academic

3D printed poly(3-hydroxybutyrate-co-3-hydroxyexanoate) scaffolds support chondrogenic potential of human primary chondrocytes during in vitro culture
Pecorini, G., Puppi, D., Richardson, S., Chen, G.-Q. & Domingos, M., 21 Feb 2025, In: Polymer. 320, 128105.
Research output: Contribution to journal › Article › peer-review

Open Access
An Engineered Biocatalyst for Enantioselective Hydrazone Reduction
Green, A. P., Hutton, A. E., Zhao, F., Ho, E., Domenech, J., Harawa, V., Brown, M. J. B., Grogan, G., Clayman, P. D. & Turner, N. J., 17 Apr 2025, (E-pub ahead of print) In: Angewandte Chemie International Edition. e202424350.
Research output: Contribution to journal › Article › peer-review

Open Access
A new set of mutations in the second transmembrane helix of the Cox2p-W56R substantially improves its allotopic expression in Saccharomyces cerevisiae
Gombeau, K., Hoffmann, S. A. & Cai, Y., 17 Apr 2025, In: Genetics. 229, 4, iyaf037.
Research output: Contribution to journal › Article › peer-review

Open Access
Cryopreservation and Post-Thaw Differentiation of Monocytes Enabled by Macromolecular Cryoprotectants which Restrict Intracellular Ice Formation
Gibson, M., Gonzalez-Martinez, N., Tomás, R. M. F., Bissoyi, A., Nagorska, A. & Ilie, A., 5 May 2025
Research output: Other contribution › peer-review

Open Access
File

11 Downloads (Pure)
Directed evolution’s selective use of quantum tunneling in designed enzymes – a combined theoretical experimental study
Korchagina, K., Balasubramani, S. G., Berreur, J., Gerard, E. F., Johannissen, L. O., Green, A. P., Hay, S. & Schwartz, S. M., 6 Feb 2025, In: Journal of Physical Chemistry B. 129, 5, p. 1555–1562
Research output: Contribution to journal › Article › peer-review

Open Access
File
20 Downloads (Pure)

1 Not started
6 Active
10 Finished

EngBioFTMA (AWARD)
Le Feuvre, R. (PI)
1/04/24 → 31/03/27
Project: Research
MESNA: Methods for enzymatic synthesis of modified nucleic acids (AWARD)
Micklefield, J. (PI) & Barran, P. (CoI)
1/07/23 → 30/06/26
Project: Research
Evolving quantum mechanical tunnelling in enzymes
Hay, S. (PI), Green, A. (CoI) & Johannissen, L. (CoI)
1/04/23 → 31/03/26
Project: Research
GENPENZ: GENERALISED PHOTOCATALYSIS BY ENZYMES
Scrutton, N. (PI), Barran, P. (CoI), Hardman, S. (CoI) & Heyes, D. (CoI)
1/12/22 → 30/11/27
Project: Research
Turing AI Fellowship: Human-AI Research Teams - Steering AI in Experimental Design and Decision-Making
Kaski, S. (PI), Bristow, R. (CoI), Cai, P. (CoI), Jay, C. (CoI) & Peek, N. (CoI)
1/10/21 → 30/09/26
Project: Research

Driving the industrial biotechnology revolution: cheaper and more sustainable chemical manufacturing through enzyme discovery, engineering and scale-up
Turner, N. (Participant), Flitsch, S. (Participant), Scrutton, N. (Participant), Micklefield, J. (Participant), Greaney, M. (Participant), Weise, N. (Participant), Hardacre, C. (Participant), Lovelock, S. (Participant) & Green, A. (Participant)
Impact: Economic, Technological, Policy, Awareness and understanding

UK Solar Chemicals Network workshop: Beyond Hydrogen
Cobb, S. (Chair), Megarity, C. (Chair) & Cowan, A. J. (Member of programme committee)
12 Nov 2024
Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc › Research
Electrochem 2024 (RSC)
Megarity, C. (Speaker)
11 Sept 2024 → 13 Sept 2024
Activity: Talk or presentation › Oral presentation › Research
38th Topical Meeting of the International Society of Electrochemistry, Manchester, UK
Megarity, C. (Speaker)
8 Sept 2024 → 11 Sept 2024
Activity: Talk or presentation › Oral presentation › Research
75th Annual Meeting of the International Society of Electrochemistry (ISE), Montreal, Canada
Megarity, C. (Keynote speaker)
18 Aug 2024 → 23 Aug 2024
Activity: Talk or presentation › Invited talk › Research
Nordbio II
Megarity, C. (Co-Organiser)
13 Jun 2024 → 14 Jun 2024
Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc › Research

Proteome analsyis of Translocation phenomenon
Dixon, N. (Creator), PRoteomics IDEntifications Database, 2018
DOI: 10.6019/PXD006474, https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD006474
Dataset
Baseline Proteomics Characterisation of Biomanufacturing Organism Halomonas Bluephagenesis
Scrutton, N. (Creator), PRoteomics IDEntifications Database, 2022
DOI: 10.6019/PXD030494, http://central.proteomexchange.org/cgi/GetDataset?ID=PXD030494
Dataset
SYNBIOCHEM Design-Build-Test-Learn pipeline
Carbonell, P. (Creator), Jervis, A. J. (Contributor), Robinson, C. J. (Contributor), Yan, C. (Contributor), Dunstan, M. (Contributor), Swainston, N. (Contributor), Vinaixa, M. (Contributor), Hollywood, K. A. (Contributor), Currin, A. (Contributor), Rattray, N. J. W. (Contributor), Taylor, S. (Contributor), Spiess, R. (Contributor), Sung, R. (Contributor), Williams, A. R. (Contributor), Fellows, D. (Contributor), Stanford, N. J. (Contributor), Mulherin, P. (Contributor), Le Feuvre, R. (Contributor), Barran, P. (Contributor), Goodacre, R. (Contributor), Turner, N. J. (Contributor), Goble, C. (Contributor), Chen, G. G. (Contributor), Kell, D. B. (Contributor), Micklefield, J. (Contributor), Breitling, R. (Contributor), Takano, E. (Contributor), Faulon, J.-L. (Contributor) & Scrutton, N. S. (Contributor), Mendeley Data, 2 May 2018
DOI: 10.17632/8g4wfwtd43.1, https://data.mendeley.com/datasets/8g4wfwtd43
Dataset
SYNBIOCHEM - Combinatorial plasmid libraries for material monomer production in Escherichia coli.
Barran, P. (Contributor), Breitling, R. (Contributor), Carbonell, P. (Creator), Currin, A. (Contributor), Dunstan, M. S. (Contributor), Hollywood, K. A. (Contributor), Jervis, A. J. (Contributor), Le Feuvre, R. (Contributor), Malone, K. J. (Contributor), Matthews, N. E. (Contributor), Micklefield, J. (Contributor), Mulherin, P. (Contributor), Robinson, C. J. (Contributor), Scrutton, N. S. (Contributor), Shapira, P. (Contributor), Spiess, R. (Contributor), Swainston, N. (Contributor), Takano, E. (Contributor), Taylor, S. (Contributor), Turner, N. J. (Contributor) & Yan, C. (Contributor), Mendeley Data, 21 Jan 2020
DOI: 10.17632/t4jtcf9dr2.2, https://data.mendeley.com/datasets/t4jtcf9dr2
Dataset
Data for Investigating Silicatein Selectivity and Specificity in Silicon-Oxygen Bond Condensation and Metathesis
Wong, L. S. (Creator) & Egedeuzu, C. (Creator), University of Manchester Figshare, 20 Jan 2025
DOI: 10.48420/26556775, https://figshare.manchester.ac.uk/articles/dataset/Data_for_b_Investigating_Silicatein_Selectivity_and_Specificity_in_Silicon-Oxygen_Bond_Condensation_and_Metathesis_b_/26556775 and one more link, https://figshare.manchester.ac.uk/articles/dataset/Data_for_b_Investigating_Silicatein_Selectivity_and_Specificity_in_Silicon-Oxygen_Bond_Condensation_and_Metathesis_b_/26556775/1 (show fewer)
Dataset

2024 ACS Bio & Med Chem Au Rising Star in Biological, Medicinal, and Pharmaceutical Chemistry
Jin, Y. (Recipient), 2024
Prize: Prize (including medals and awards)
2024 RSC Chemistry Biology Interface Horizon Prize: Rita and John Cornforth Award
Jin, Y. (Recipient), 2024
Prize: Prize (including medals and awards)
Academy of Medical Sciences Spring Board Award
Jin, Y. (Recipient), 1 Feb 2018
Prize: Prize (including medals and awards)
BBSRC Discovery Fellowship
Rowbotham, J. (Recipient), 2021
Prize: Fellowship awarded competitively
BBSRC Future Leader Fellowship
Van Munster, J. (Recipient), May 2017
Prize: Fellowship awarded competitively

THE OBSERVER: The 10 biggest science stories of 2022 – chosen by scientists
Takano, E.
18/12/22
1 Media contribution
Press/Media: Expert comment
Another giant leap for mankind
Roberts, A.
14/08/22
1 item of Media coverage
Press/Media: Other
PHYS.ORG: Newly engineered enzyme speeds up slow organic reaction
Green, A.
24/05/22
1 item of Media coverage
Press/Media: Research
BBC CLICK: Space homes
Koncherry, V. & Roberts, A.
14/05/22
1 item of Media coverage
Press/Media: Research
Colonies on Mars and sustainable construction with human blood proteins? An interview with Dr Aled Roberts.
Mccarthy, A. & Roberts, A.
20/01/22
1 Media contribution
Press/Media: Blogs and social media

Biochemical and Biophysical Sciences Technology Platform
Heyes, D. (Senior Technical Specialist), Boothman, C. (Senior Technical Specialist), Cliffe, L. (Technical Specialist), Dunstan, M. (Senior Technical Specialist), Golovanova, M. (Senior Technician), Hoeven, R. (Technical Specialist), Lopez Perez, R. (Senior Technician), Sakuma, M. (Senior Technician), Tait, S. (Senior Technician) & Tilakaratna, V. (Senior Technician)
FSE Research
Facility/equipment: Platform
Biochemical preparation facility
Golovanova, M. (Senior Technician), Lopez Perez, R. (Senior Technician), Sakuma, M. (Senior Technician), Tait, S. (Senior Technician) & Tilakaratna, V. (Senior Technician)
FSE Research
Facility/equipment: Facility

Chemical Biology and Biological Chemistry

Collaborations and top research areas from the last five years

Profiles

Research output

Projects

Impacts

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Press/Media

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