Research output per year
Research output per year
Organization profile
The Division of Cardiovascular Sciences combines clinical, translational and basic science research with the aim of translating our understanding of the cellular and molecular processes underlying cardiovascular disease into improved clinical treatments and patient care.
We have two fully integrated and interdisciplinary research themes that bring together researchers with common interests and facilitate collaboration across multiple sites.
Cardiac research
Our clinicians and scientists closely work together to investigate mechanisms responsible for clinical entities including congenital heart failure and cardiac rhythm disturbances.
Areas covered include experimental cardiology, genetics and development, and clinical cardiovascular research.
Vascular and stroke research
Our vascular research uses multidisciplinary approaches to advance our understanding of the mechanisms underlying small and large artery function in health and disease.
Stroke research includes translational studies of immune modulation in ischaemic stroke, primary intracerebral haemorrhage and subarachnoid haemorrhage, studies in stroke rehabilitation and implementation into clinical practice.
Research aims
We aim to develop high-quality research programmes by:
- Developing an integrated bench-to-bedside translational approach, for understanding the underlying mechanisms responsible for the functioning of the cardiovascular system in both health and disease.
- Training future generations of investigators to the highest level, not only in those techniques and concepts traditionally allied to cardiovascular research, but also in complementary methodologies that traverse the disciplinary interfaces.
- Promoting and expanding interdisciplinary bioscience.
We also aim to harness and coordinate people's efforts to produce a step-change in generating new knowledge through cutting-edge research and to translate that knowledge to improve health and reduce inequalities.
We have a breadth of expertise and a commitment to tackle issues of global importance in the field of cardiovascular sciences.
Head of Division
Our researchers
View list of researchers within the Division
Contact
Lesley Jordan
tel: +44 (0)1612751193
email: lesley.jordan@manchester.ac.uk
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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Sabu Abraham, MSc, PhD
- Division of Cardiovascular Sciences (L5) - Lecturer in Cardiovascular Medicine
Person: Academic
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A high-resolution melt curve toolkit to identify lineage-defining SARS-CoV-2 mutations
Fraser, A. J., Greenland-Bews, C., Kelly, D., Williams, C. T., CONDOR Steering Group, LSTM Diagnostics Group, Body, R., Adams, E. R., Cubas Atienzar, A., Edwards, T., Allen, D. J. & Dark, P., 8 Mar 2023, In: Scientific Reports. 13, 1, 3887.Research output: Contribution to journal › Article › peer-review
Open Access -
Analysis of mRNA Subcellular Distribution in Collective Cell Migration
Bradbury, J., Lovegrove, H., Giralt-Pujol, M. & Herbert, S., 5 Feb 2023, Cell Migration in Three Dimensions. Margadant, C. (ed.). New York, USA: Humana Press, Inc, p. 389–407 19 p. (Methods in Molecular Biology; vol. 2608).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Open Access -
An in vitro approach to understand contribution of kidney cells to human urinary extracellular vesicles
Barreiro, K., Lay, A. C., Leparc, G., Tran, V. D. T., Rosler, M., Dayalan, L., Burdet, F., Ibberson, M., Coward, R. J. M., Huber, T. B., Krämer, B. K., Delic, D. & Holthofer, H., 13 Feb 2023, In: Journal of Extracellular Vesicles. 12, 2, 12304.Research output: Contribution to journal › Article › peer-review
Open Access -
Atrioventricular node dysfunction in pressure overload-induced heart failure—Involvement of the immune system and transcriptomic remodelling
Wilson, C., Zi, M., Smith, M., Hussain, M., D’Souza, A., Dobrzynski, H. & Boyett, M. R., 4 Apr 2023, In: Frontiers in Pharmacology. 14Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Downloads (Pure) -
Clinical and histopathologic predictors of recurrent glomerulonephritis after kidney transplantation
Chukwu, C., Holmberg, C., Storrar, J., Middleton, R., Sinha, S., Kalra, P., Shawki, H. & Rao, A., 23 Mar 2023, In: Clinical Transplantation. 13 p., e14970.Research output: Contribution to journal › Article › peer-review
Open Access
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NIHR Manchester Biomedical Research Centre
Bruce, I., Lord, G., Lennon, R., Black, G., Wedge, D., Morris, A., Hussell, T., Sharrocks, A., Stivaros, S., Buch, M., Gough, J., Kostarelos, K., Thistlethwaite, F., Kadler, K., Barton, A., Hyrich, K., Mcbeth, J., O'Neill, T., Vestbo, J., Simpson, A., Singh, S., Smith, J., Felton, T., Murray, C., Griffiths, C., Cullum, N., Rhodes, L., Warren, R., Paus, R., Dumville, J., Viros Usandizaga, A., Keavney, B., Tomaszewski, M., Allan, S., Body, R., Cartwright, E., Heagerty, A., Kalra, P., Miller, C., Rutter, M., Smith, C., Trafford, A., Evans, D., Crosbie, E., Crosbie, P., Harvie, M., Howell, S., Renehan, A., Dive, C., Blackhall, F., Landers, D., Krebs, M., Cook, N., Clarke, R., Taylor, S., Jorgensen, C., Lorigan, P., Jayson, G., Valle, J., Mccabe, M., Armstrong, A., Freitas, A., Illidge, T., Choudhury, A., Hoskin, P., West, C., Van Herk, M., Faivre-Finn, C., Bristow, R., Kirkby, K., Birtle, A., Mackay, R., Radford, J., Linton, K., Higham, C., Munro, K., Plack, C., Arden Armitage, C., Bruce, I., Moore, D., Saunders, G., Stone, M., Haddock, G., Lewis, S., Elliott, R., Green, J., Lovell, K., Morrison, A., Shaw, J., Bucci, S., Ainsworth, J., Webb, R., Newman, W., Banka, S., Clayton-Smith, J., Payne, K., Moldovan, R., Wynn, R. & Jones, S.
1/12/22 → 30/11/27
Project: Research
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Modelling Human Genomic Variation Using Markov Random Fields: A Feasibility Study
1/11/22 → 30/06/23
Project: Research
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Molecular basis of age-related neurodegenerative diseases
Cooper, G., Cartwright, E. & Eisner, D.
1/12/21 → 30/11/23
Project: Research
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Investigation of genetic mechanisms underlying susceptibility to Congenital Heart Disease.
1/08/21 → 31/07/26
Project: Research
Activities
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Vijay Rajagopal
Christian Pinali (Host)
12 Oct 2022 → 13 Oct 2022Activity: Hosting a visitor › Hosting an academic visitor
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Characterisation of carotid body mitochondrial function in the sheep
Agnieszka Swiderska (Speaker)
30 Jun 2022Activity: Talk or presentation › Oral presentation
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Human-nature connections and exchanges through the everyday: A transcultural narrative
Junyan Ye (Discussant)
28 Jun 2022Activity: Talk or presentation › Invited talk
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Pint of Science Festival 2022
Jade Taylor (Organiser), Felicity Hunter (Organiser), Brendan Capey (Organiser), Josh Mouland (Participant), Alice Mortimer (Participant), Enrique Amaya (Participant), Maria Canal (Participant), Devin Simpkins (Participant), Holly Shiels (Participant), Rowan Green (Participant) & Giuseppe DAngelo (Participant)
9 May 2022 → 11 May 2022Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc
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Royal College of Emergency Medicine (External organisation)
Anisa Jafar (Academic expert member)
1 Feb 2022 → …Activity: Membership › Membership of committee
Datasets
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Raw data for STX18-AS1
Liu, Y. (Creator), Mendeley Data, 10 Oct 2022
DOI: 10.17632/rpzs6fcdhz.1, https://data.mendeley.com/datasets/rpzs6fcdhz
Dataset
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The impact of maintaining serum potassium ≥3.6 mEq/L vs ≥4.5 mEq/L on the incidence of new-onset atrial fibrillation in the first 120 hours after isolated elective coronary artery bypass grafting – study protocol for a randomised feasibility trial fo [...]
Campbell, N. (Contributor), Allen, E. (Contributor), Sanders, J. (Contributor), Swinson, R. (Contributor), Birch, S. (Contributor), Sturgess, J. (Contributor), Al-Subaie, N. (Contributor), Elbourne, D. (Contributor), Montgomery, H. (Contributor) & O'Brien, B. (Contributor), figshare , 28 Dec 2017
DOI: 10.6084/m9.figshare.c.3963417.v1, https://figshare.com/collections/The_impact_of_maintaining_serum_potassium_3_6_mEq_L_vs_4_5_mEq_L_on_the_incidence_of_new-onset_atrial_fibrillation_in_the_first_120_hours_after_isolated_elective_coronary_artery_bypass_grafting_study_protocol_for_a_randomised_feasibility_trial_for_the_pro/3963417/1
Dataset
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Data for: The unsolved role of heightened connectivity from the unaffected hemisphere to paretic arm muscles in chronic stroke.
Hammerbeck, U. (Contributor), Hoad, D. (Contributor), Greenwood, R. (Contributor) & Rothwell, J. C. (Contributor), Mendeley Data, 26 Apr 2021
DOI: 10.17632/xccczv7mff.1, https://data.mendeley.com/datasets/xccczv7mff
Dataset
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Supplementary Material for: Use of Online Conductivity Monitoring to Study Sodium Mass Balance in Chronic Haemodialysis Patients: Prospects for Treatment Individualisation
Odudu, A. (Creator), Lambie, S. (Creator), Taal, M. W. (Creator), Fluck, R. J. (Creator) & McIntyre, C. W. (Creator), figshare , 27 Jul 2011
DOI: 10.6084/m9.figshare.5122558
Dataset
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Reverbα regulates liver and adipose tissue response to systemic metabolic challenge
Unwin, R. (Creator), Mendeley Data, 6 Nov 2019
DOI: 10.17632/wskyz3rhsg.3, https://data.mendeley.com/datasets/wskyz3rhsg
Dataset
Prizes
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1st Place poster prize
Madders, George (Recipient), 1 Jun 2017
Prize: Prize (including medals and awards)
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2nd Place - Best Presentation
Rogers, Steven (Recipient), Sep 2017
Prize: Prize (including medals and awards)
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2nd Place poster prize
Madders, George (Recipient), 1 May 2018
Prize: Prize (including medals and awards)
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Academy of medical sciences starter grant for clinical lecturers
Hutchings, David (Recipient), 3 Mar 2022
Prize: Fellowship awarded competitively
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Press/Media
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THE MIRROR: 'Biodegradable gel injected into damaged hearts can help them heal after injury'
Katharine King
25/07/22
1 Media contribution
Press/Media: Research
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CBS: Researchers create special gel to repair damage caused by heart attacks
Katharine King
9/06/22
1 item of Media coverage
Press/Media: Research
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VARIOUS NATIONAL MEDIA: Injectable gel to repair damage after a heart attack
Katharine King
8/06/22 → 9/06/22
5 items of Media coverage
Press/Media: Research
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NEW SCIENTIST: High blood pressure may be treated by burning nerves near the kidneys
4/04/22
1 Media contribution
Press/Media: Expert comment
Student theses
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3D anatomical modelling of the human cardiac conduction system
Author: Atkinson, A., 3 Jan 2015Supervisor: Dobrzynski, H. (Supervisor) & Boyett, M. (Supervisor)
Student thesis: Master of Philosophy
File -
3-Dimensional SEM Studies of the Sarcoplasmic Reticulum in Chicken Hearts
Author: Newman, B., 31 Dec 2016Supervisor: Shiels, H. (Supervisor) & Codd, J. (Supervisor)
Student thesis: Master of Philosophy
File -
A Clinical and Molecular Study of the Growth Disorder 3-M Syndrome
Author: Murray, P., 1 Aug 2012Supervisor: Clayton, P. (Supervisor) & Black, G. (Supervisor)
Student thesis: Phd
File -
A comparative study investigating the effects of different methodologies on the maturation of human induced pluripotent stem cell derived cardiomyocytes
Author: Ryding, K., 1 Aug 2023Supervisor: Venetucci, L. (Supervisor)
Student thesis: Phd
File -
ADVANCED CARDIAC IMAGING IN LEFT VENTRICULAR HYPERTROPHY
Author: Reid, A., 31 Dec 2018Supervisor: Miller, C. (Supervisor), Ray, S. (Supervisor) & Schmitt, M. (Supervisor)
Student thesis: Phd
File