Research output per year
Research output per year
The Division of Evolution, Infection and Genomics spans fundamental biological research into evolution of molecules and organisms, through to applications of modern genomic techniques for the understanding, diagnosis and treatment of genetic disease in humans.
Our research is unified by the concept of the genome as a platform from which biological function and dysfunction can be understood. We seek to understand how changes in genes and genomes lead to changes in all forms of phenotype, ranging from speciation events to alterations in Mendelian and quantitative traits that underlie behaviour and disease.
All life can be understood in terms of evolutionary processes, from microbial and viral biology through to entire organisms and human disease.
Our researchers compare both molecular sequences and whole organism physiology and phenotype to derive inference about the origins of species, genes, and traits and how adaptive processes shape biological function through changes to the genome.
Functional genomics seeks to characterise and quantify all the molecules encoded in the genome, such as RNA and protein, to study how environment, lifecycle or pathology lead to changes in these molecular signatures.
This in turn allows us to understand processes such as development, response to environmental stress, biological signalling, disease and dysfunction.
Infections caused by bacteria, fungi and viruses are a major causes of human disease and by 2050 the impact of antimicrobial resistance is expected to drive deaths above those seen for cancer.
Our multidisciplinary Infection research benefits from proximity to clinics and addresses a triad of factors – host, pathogen and microbiome – to innovate the discovery of new therapies, adapt the use of existing therapies and improve diagnosis.
Our ability to rapidly sequence human genomes underpins a new age of personalised medicine. Our research covers a broad spectrum of healthcare and includes programmes in cancer genetics, neuropsychiatry, developmental and functional eye disorders, biochemical genetics and birth defects.
The overarching aim is to identify the genetic basis of both single gene and complex disorders.
View a list of researchers within the Division
Professor Simon Hubbard
tel: +44 (0)161 306 8930
email: simon.hubbard@manchester.ac.uk
Person: Academic
Person: Academic
Person: Academic
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
15/03/23 → 14/03/25
Project: Research
Newman, W., Adamson, A., Mcdermott, J., Turner, M. & Wong, L. S.
1/02/23 → 31/01/24
Project: Research
Bruce, I., Lord, G., Lennon, R., Black, G., Wedge, D., Morris, A., Hussell, T., Sharrocks, A., Stivaros, S., Buch, M., Gough, J., Kostarelos, K., Thistlethwaite, F., Kadler, K., Barton, A., Hyrich, K., Mcbeth, J., O'Neill, T., Vestbo, J., Simpson, A., Singh, S., Smith, J., Felton, T., Murray, C., Griffiths, C., Cullum, N., Rhodes, L., Warren, R., Paus, R., Dumville, J., Viros Usandizaga, A., Keavney, B., Tomaszewski, M., Allan, S., Body, R., Cartwright, E., Heagerty, A., Kalra, P., Miller, C., Rutter, M., Smith, C., Trafford, A., Evans, D., Crosbie, E., Crosbie, P., Harvie, M., Howell, S., Renehan, A., Dive, C., Blackhall, F., Landers, D., Krebs, M., Cook, N., Clarke, R., Taylor, S., Jorgensen, C., Lorigan, P., Jayson, G., Valle, J., Mccabe, M., Armstrong, A., Freitas, A., Illidge, T., Choudhury, A., Hoskin, P., West, C., Van Herk, M., Faivre-Finn, C., Bristow, R., Kirkby, K., Birtle, A., Mackay, R., Radford, J., Linton, K., Higham, C., Munro, K., Plack, C., Arden Armitage, C., Bruce, I., Moore, D., Saunders, G., Stone, M., Haddock, G., Lewis, S., Elliott, R., Green, J., Lovell, K., Morrison, A., Shaw, J., Bucci, S., Ainsworth, J., Webb, R., Newman, W., Banka, S., Clayton-Smith, J., Payne, K., Moldovan, R., Wynn, R. & Jones, S.
1/12/22 → 30/11/27
Project: Research
Dickson, A., Barran, P., Pitt, A., Rattray, M. & Schwartz, J.
1/10/21 → 30/09/26
Project: Research
Goran Nenadic (Participant) & David Robertson (Participant)
Impact: Economic, Technological, Health and wellbeing
Peter Clayton (Participant), Graeme Black (Participant), Andrew Read (Participant), Forbes Manson (Participant), Daniel Hanson (Participant) & Leena Patel (Participant)
Impact: Health impacts
Rebecca Bromley (Participant) & Jill Clayton-Smith (Participant)
Impact
Caroline Jay (Participant), Alaa Alahmadi (Participant), Markel Vigo (Participant), Alan Davies (Participant), Jennifer Royle (Participant), Leanna Goodwin (Participant), Katharine Cresswell (Participant), Zahra Arain (Participant) & Katherine Dempsey (Participant)
Impact: Technological, Health and wellbeing
Alys Young (Participant), Katherine Rogers (Participant), Emma Ferguson-Coleman (Participant), Rosemary Oram (Participant), Claire Dodds (Participant), Rachel Belk (Participant), Gemma Shields (Participant), John Keady (Participant), Linda Davies (Participant) & Karina Lovell (Participant)
Impact: Health and wellbeing, Society and culture
Wendy Thompson (Other), Michael Bottery (Other), Michael Brockhurst (Other), Lucie Byrne-Davis (Other) & Michael Bromley (Other)
Activity: Publication peer-review and editorial work › Editorial work
Claudia Igler (Participant)
Activity: Participating in or organising event(s) › Participating in a conference, workshop, exhibition, performance, inquiry, course etc
Shiu-Wan Chan (Guest editor)
Activity: Publication peer-review and editorial work › Editorial work
Gerrard, D. (Creator), Hanley, N. (Owner) & Jennings, R. (Data Manager), The European Genome-phenome Archive, 2019
https://ega-archive.org/datasets/EGAD00001004335
Dataset
Ames, R. (Contributor), Talavera, D. (Contributor), Williams, S. (Contributor), Robertson, D. (Contributor) & Lovell, S. (Contributor), figshare , 18 Feb 2016
DOI: 10.6084/m9.figshare.c.3618035.v1, https://figshare.com/collections/Binding_interface_change_and_cryptic_variation_in_the_evolution_of_protein-protein_interactions/3618035/1
Dataset
Porter, L. F. (Contributor), Gallego-Pinazo, R. (Contributor), Keeling, C. L. (Contributor), Kamieniorz, M. (Contributor), Zoppi, N. (Contributor), Colombi, M. (Contributor), Giunta, C. (Contributor), Bonshek, R. (Contributor), Manson, F. (Contributor) & Black, G. (Contributor), figshare , 11 Nov 2015
DOI: 10.6084/m9.figshare.c.3598280.v1, https://figshare.com/collections/Bruch_s_membrane_abnormalities_in_PRDM5-related_brittle_cornea_syndrome/3598280/1
Dataset
Popp, I. (Contributor), Punekar, M. (Contributor), Telford, N. (Contributor), Stivaros, S. (Contributor), Chandler, K. (Contributor), Minnis, M. (Contributor), Castleton, A. (Contributor), Higham, C. (Contributor), Hopewell, L. (Contributor), Evans, D. (Contributor), Raams, A. (Contributor), Arjan, T. (Contributor), Meyer, S. (Contributor) & Schindler, D. (Contributor), figshare , 11 Jan 2018
DOI: 10.6084/m9.figshare.c.3975192.v1, https://figshare.com/collections/Fanconi_anemia_with_sun-sensitivity_caused_by_a_Xeroderma_pigmentosum-associated_missense_mutation_in_XPF/3975192/1
Dataset
Ankers, J. M. (Creator), Awais, R. (Creator), Jones, N. (Creator), Boyd, J. (Creator), Ryan, S. (Creator), Adamson, A. (Creator), Harper, C. (Creator), Bridge, L. J. (Creator), Spiller, D. (Creator), Jackson, D. (Creator), Paszek, P. (Creator), Sée, V. (Creator) & White, M. (Creator), Dryad Digital Repository, 17 May 2016
DOI: 10.5061/dryad.th18q
Dataset
Sergouniotis, Panos (Recipient), 7 May 2016
Prize: Prize (including medals and awards)
Sergouniotis, Panos (Recipient), 24 Feb 2017
Prize: Prize (including medals and awards)
Briggs, Tracy (Recipient), 2011
Prize: Prize (including medals and awards)
Sergouniotis, Panos (Recipient), 1 Apr 2015
Prize: Prize (including medals and awards)
4/07/23
1 Media contribution
Press/Media: Research
William Newman & John Mcdermott
9/02/23 → 2/04/23
5 items of Media coverage
Press/Media: Research
4/01/23
1 item of Media coverage
Press/Media: Expert comment
Binita Kane & Tracy Briggs
3/01/23
1 Media contribution
Press/Media: Expert comment
Matthew Cobb & Brian Cox
10/12/22
1 item of Media coverage
Press/Media: Expert comment
Supervisor: Hubbard, S. (Supervisor) & Delneri, D. (Supervisor)
Student thesis: Phd
Supervisor: Hubbard, S. (Supervisor) & Schwartz, J. (Supervisor)
Student thesis: Phd
Supervisor: Kell, D. (Supervisor) & Day, P. (Supervisor)
Student thesis: Phd
Supervisor: Ford, R. (Supervisor) & Baldock, C. (Supervisor)
Student thesis: Phd
Supervisor: Cobb, M. (Supervisor) & Hager, R. (Supervisor)
Student thesis: Master of Philosophy