Division of Molecular & Cellular Function (L5)

Dennis Alferez-Castro, BSc, PhD
- Division of Molecular & Cellular Function (L5) - Teaching Associate
Person: Academic
Viki Allan, BSc, DPhil
- viki.allanmanchester.acuk
- Division of Molecular & Cellular Function (L5) - Professor of Cell Biology
Person: Academic
Hilary Ashe, BSc, DPhil
- Division of Molecular & Cellular Function (L5) - Professor
Person: Academic
Mark Ashe, BSc, DPhil
- Mark.P.Ashemanchester.acuk
- Division of Molecular & Cellular Function (L5) - Professor
Person: Academic
Caroline Bowsher, BSc, PhD
- Caroline.Bowshermanchester.acuk
- Division of Molecular & Cellular Function (L5) - Professor
- Office of the President and Vice Chancellor (L5) - Academic Lead for Digital Learning Env
Person: Academic, UnknownHonType

Different mechanisms link gain and loss of kinesin functions to axonal degeneration
Yu-Ting, L., Voelzmann, A., Owens, M., Day, M., Cairns, W., Jones, E., Dajas-bailador, F., McCann, S., Murphy, T., Tortoishell, H., Parkin, J., Bailey, D. M. D., Landgraf, M. & Prokop, A., 1 Jan 2025, Cold Spring Harbor Laboratory Press, (bioRxiv).
Research output: Preprint/Working paper › Preprint
An avidity-driven mechanism of extracellular BMP regulation by Twisted gastrulation
Moore, G., Forbes-Beadle, L., Birchenough, H., Baldock, C. & Ashe, H. L., 10 Jul 2024, p. 1-34, 34 p.
Research output: Preprint/Working paper › Preprint
An ILK/STAT3 pathway controls glioblastoma stem cell plasticity.
Loftus, A. E. P., Romano, M. S., Phuong, A. N., McKinnel, B. J., Muir, M. T., Furqan, M., Dawson, J. C., Avalle, L., Douglas, A. T., Mort, R. L., Byron, A., Carragher, N. O., Pollard, S. M., Brunton, V. G. & Frame, M. C., 25 Sept 2024, (E-pub ahead of print) In: Developmental cell.
Research output: Contribution to journal › Article › peer-review

Open Access
An NFATc1/SMAD3/cJUN Complex Restricted to SMAD4-Deficient Pancreatic Cancer Guides Rational Therapies
Nagarajan, S. & et al., 1 Feb 2024, In: Gastroenterology. 166, 2, p. 298-312.e14
Research output: Contribution to journal › Article › peer-review

Open Access
File
18 Downloads (Pure)
A simple MiMIC based approach for tagging endogenous genes to visualise live transcription in Drosophila
Beadle, L. F., Sutcliffe, C. & Ashe, H. L., 25 Nov 2024, In: Development.
Research output: Contribution to journal › Article › peer-review

5 Active
7 Finished
7 Not started

Laser capture dissection for spatially-resolved -omics analysis
Swift, J. (PI), Caswell, P. (CoI), Chang, J. (CoI), Clarke, R. (CoI), Couper, K. (CoI), Dyer, D. (CoI), Eckersley, A. (CoI), Gilmore, A. (CoI), Hadjidemetriou, M. (CoI), Hayes, A. (CoI), Hepworth, M. (CoI), Hussell, T. (CoI), Knight, D. (CoI), Kostarelos, K. (CoI), Lennon, R. (CoI), March, P. (CoI), Meng, Q.-J. (CoI), Menon, M. (CoI), Piper Hanley, K. (CoI), Reid, A. (CoI), Sharrocks, A. (CoI), Sherratt, M. (CoI), Thornton, D. (CoI), Unwin, R. (CoI), Wong, J. (CoI) & Woolner, S. (CoI)
1/07/24 → 28/02/25
Project: Research
Oxford Nanopore PromethION
Ellingford, J. (PI), Adamson, A. (CoI), Banka, S. (CoI), Black, G. (CoI), Brockhurst, M. (CoI), Coyte, K. (CoI), Gifford, D. (CoI), Hayes, A. (CoI), Hubbard, S. (CoI), Lagator, M. (CoI), Mcdermott, J. (CoI), Newman, W. (CoI), Sergouniotis, P. (CoI), Sharrocks, A. (CoI) & Wedge, D. (CoI)
31/07/23 → 30/07/26
Project: Research
NIHR Manchester Biomedical Research Centre
Bruce, I. (PI), Lord, G. (CoI), Lennon, R. (CoI), Black, G. (CoI), Wedge, D. (CoI), Morris, A. (CoI), Hussell, T. (CoI), Sharrocks, A. (CoI), Stivaros, S. (CoI), Buch, M. (CoI), Gough, J. (CoI), Kostarelos, K. (CoI), Thistlethwaite, F. (CoI), Kadler, K. (CoI), Barton, A. (CoI), Hyrich, K. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI), Vestbo, J. (CoI), Simpson, A. (CoI), Singh, S. (CoI), Smith, J. (CoI), Felton, T. (CoI), Murray, C. (CoI), Griffiths, C. (CoI), Cullum, N. (CoI), Rhodes, L. (CoI), Warren, R. (CoI), Paus, R. (CoI), Dumville, J. (CoI), Viros Usandizaga, A. (CoI), Keavney, B. (CoI), Tomaszewski, M. (CoI), Allan, S. (CoI), Body, R. (CoI), Cartwright, E. (CoI), Heagerty, A. (CoI), Kalra, P. (CoI), Miller, C. (CoI), Rutter, M. (CoI), Smith, C. (CoI), Trafford, A. (CoI), Evans, D. (CoI), Crosbie, E. (CoI), Crosbie, P. (CoI), Harvie, M. (CoI), Howell, S. (CoI), Renehan, A. (CoI), Dive, C. (CoI), Blackhall, F. (CoI), Landers, D. (CoI), Krebs, M. (CoI), Cook, N. (CoI), Clarke, R. (CoI), Taylor, S. (CoI), Jorgensen, C. (CoI), Lorigan, P. (CoI), Jayson, G. (CoI), Valle, J. (CoI), Mccabe, M. (CoI), Armstrong, A. (CoI), Freitas, A. (CoI), Illidge, T. (CoI), Choudhury, A. (CoI), Hoskin, P. (CoI), West, C. (CoI), Van Herk, M. (CoI), Faivre-Finn, C. (CoI), Bristow, R. (CoI), Kirkby, K. (CoI), Birtle, A. (CoI), Mackay, R. (CoI), Radford, J. (CoI), Linton, K. (CoI), Higham, C. (CoI), Munro, K. (CoI), Plack, C. (CoI), Arden Armitage, C. (CoI), Bruce, I. (CoI), Moore, D. (CoI), Saunders, G. (CoI), Stone, M. (CoI), Haddock, G. (CoI), Lewis, S. (CoI), Elliott, R. (CoI), Green, J. (CoI), Lovell, K. (CoI), Morrison, A. (CoI), Shaw, J. (CoI), Bucci, S. (CoI), Ainsworth, J. (CoI), Webb, R. (CoI), Newman, W. (CoI), Banka, S. (CoI), Clayton-Smith, J. (CoI), Payne, K. (CoI), Moldovan, R. (CoI), Wynn, R. (CoI) & Jones, S. (CoI)
1/12/22 → 30/11/27
Project: Research
Measuring tumour radioresistance to improve radiotherapy outcomes (PROJECT)
Choudhury, A. (PI), Bristow, R. (CoI), Forker, L. (CoI), Hoskin, P. (CoI), Nagarajan, S. (CoI), Wedge, D. (CoI) & West, C. (CoI)
1/10/22 → 30/09/25
Project: Research
New paradigms in fibroblasts and immune cells coordinate in matrix homeostasis in health and disease
Chang, J. (PI)
1/04/22 → 31/03/27
Project: Research

Accurate in vitro prediction of in vivo genotoxicity and cancer hazard; reducing costs to industry and the use of animals in research
(Participant), (Participant), (Participant), (Participant), (Participant), (Participant) & (Participant)
Impact: Economic impacts, Health impacts, Technological impacts
Re-animating school biology lessons through teaching with living flies
Prokop, A. (Participant) & (Participant)
Impact: Attitudes and behaviours, Awareness and understanding, Society and culture

Faculty of Biology, Medicine and Health (Organisational unit)
Byron, A. (Member)
2024 → …
Activity: Membership › Membership of committee › Teaching and Research
Faculty of Biology, Medicine and Health (Organisational unit)
Byron, A. (Academic expert member)
2024 → …
Activity: Membership › Membership of committee › Research
Cap on, cap off: the importance of 5' capping for RNA fate
Grzechnik, P. (Speaker)
29 Jun 2023
Activity: Talk or presentation › Invited talk › Research
56th Annual Meeting of the ESR Spectroscopy Group of the Royal Society of Chemistry
Pliotas, C. (Chair)
27 Mar 2023 → 30 Mar 2023
Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc › Research
Biochemical Society (External organisation)
Pliotas, C. (Academic expert member)
2023 → …
Activity: Membership › Membership of professional association › Teaching and Research

Human neuronal extracellular vesicles contain a transcriptional network and tetraspanin-defined subpopulations
Hicks, D. (Creator), Jones, A. C. (Creator), J. Corbett, N. (Creator), Fisher, K. (Creator), Brown, S. P. (Creator), Ashe, M. (Creator) & Hooper, N. (Creator), PRoteomics IDEntifications Database, 8 Sept 2021
https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD015255
Dataset
ERBB2 signalling and functions in oesophageal cancer
Francavilla, C. (Creator), PRoteomics IDEntifications Database, 2023
https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD029180
Dataset
Petunia chloroplast genome
Day, A. (Creator), NCBI Nucleotide, 4 Jan 2019
https://www.ncbi.nlm.nih.gov/nuccore/MF459662
Dataset
Proteomics analysis of the effect of deletion and mutation of eIF4E binding proteins Caf20 and Eap1 on yeast via LC-MSMS.
Pavitt, G. (Creator), PRoteomics IDEntifications Database, 2016
DOI: 10.6019/PXD001348, https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD001348
Dataset
A gatekeeper residue controls transcriptional activity of the extracellular signal-regulated protein kinase 5 (ERK5) through molecular interactions with the C terminal tail.
Francavilla, C. (Creator), PRoteomics IDEntifications Database, 2020
https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD014028
Dataset

Awarded the MRC Early Career Impact Prize
Chang, J. (Recipient), 2024
Prize: Prize (including medals and awards)
BBSRC New Investigator Award
Pliotas, C. (Recipient), 23 Jun 2019
Prize: Prize (including medals and awards)
Best Publication of the Year
Byron, A. (Recipient), 2016
Prize: Prize (including medals and awards)
Biochemistry Prize
Byron, A. (Recipient), 2002
Prize: Other distinction
Biochemistry Prize
Byron, A. (Recipient), 2004
Prize: Other distinction

Nature Plants: expert opinion on cytoplasmic inheritance
Day, A.
18/01/23
1 Media contribution
Press/Media: Expert comment
MEDICAL NEWS TODAY: Why fever can be your friend in times of illness
White, M.
14/03/22
1 item of Media coverage
Press/Media: Expert comment
BBC programme "Food:Truth or scare"
Sharrocks, A.
22/07/20
1 Media contribution
Press/Media: Other
THE OBSERVER: As lockdown consensus unravels, Boris Johnson divides nation and party
Ford, R.
17/05/20
1 Media contribution
Press/Media: Expert comment
THE TIMES: Cancer risk: Splash of milk in your tea could cut chance of throat cancer
Sharrocks, A.
20/03/19
1 Media contribution
Press/Media: Expert comment

Division of Molecular & Cellular Function (L5)

Organisation profile

Organisation profile

Collaborations and top research areas from the last five years

Profiles

Research output

Projects

Impacts

Activities

Datasets

Prizes

Press/Media