Research output per year
Research output per year
- 1 - 50 out of 300 results
Search results
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2025
Bi-allelic variants in DAP3 result in reduced assembly of the mitoribosomal small subunit with altered apoptosis and a Perrault-syndrome-spectrum phenotype
DDD Study, Smith, T. B., Kopajtich, R., Demain, L. A. M., Rea, A., Thomas, H. B., Schiff, M., Beetz, C., Joss, S., Conway, G. S., Shukla, A., Yeole, M., Radhakrishnan, P., Azzouz, H., Ben Chehida, A., Elmaleh-Bergès, M., Glasgow, R. I. C., Thompson, K., Oláhová, M. & He, L. & 19 others, , 2 Jan 2025, In: American Journal of Human Genetics. 112, 1, p. 59-74 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Combined PARP14 Inhibition and PD-1 Blockade Promotes Cytotoxic T Cell Quiescence and Modulates Macrophage Polarization in Relapsed Melanoma
Leshem, R., Sefton, K. N., Wong, C. W., Lin, I.-H., Isaac, D. T., Niepel, M. & Hurlstone, A., 27 Jan 2025, In: Journal for ImmunoTherapy of Cancer. 13, 1, e010683.Research output: Contribution to journal › Article › peer-review
Open Access -
Compensatory increase in oxygen extraction fraction is associated with age-related cerebrovascular disease
McFadden, J., Matthews, J., Scott, L., Herholz, K., Dickie, B., Haroon, H., Sparasci, O., Ahmed, S., Kyrtata, N., Parker, G. J. M., Emsley, H. C. A., Handley, J., Lohezic, M. & Parkes, L. M., 28 Jan 2025, (E-pub ahead of print) In: NeuroImage. Clinical. 45, 10 p., 103746.Research output: Contribution to journal › Article › peer-review
Open Access -
Early metabolic changes in the brain of Alzheimer's disease rats are driven by GLAST+ cells
Morrey, W. J., Ceyzériat, K., Amossé, Q., Badina, A. M., Dickie, B., Schiessl, I., Tsartsalis, S., Millet, P., Boutin, H. & Tournier, B. B., 7 Feb 2025, (E-pub ahead of print) In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. p. 271678X251318923Research output: Contribution to journal › Article › peer-review
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Expression and purification of Mycobacterium tuberculosis F420-dependent glucose-6-phosphate dehydrogenase enzyme using Escherichia coli
Aderemi, A. V., Snee, M., Tunnicliffe, R. B., Golovanova, M., Cain, K. M., Munro, A. W., Waltho, J. P. & Leys, D., 1 Apr 2025, In: Protein Expression and Purification. 228, 106650.Research output: Contribution to journal › Article › peer-review
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Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice
Cook, P. C., Brown, S. L., Houlder, E. L., Furlong-Silva, J., Conn, D. P., Colombo, S. A. P., Baker, S., Svedberg, F. R., Howell, G., Bertuzzi, M., Boon, L., Konkel, J. E., Thornton, C. R., Allen, J. E. & MacDonald, A. S., 22 Jan 2025, In: Nature Communications. 16, 1, 928.Research output: Contribution to journal › Article › peer-review
Open Access -
MRI detects blood-brain barrier alterations in a rat model of Alzheimer’s disease and lung infection
Ohene, Y., Morrey, W. J., Powell , E., Smethers, K. F., Luka, N., South, K., Berks, M., Lawrence, C. B., Parker, G. J. M., Parkes, L. M., Boutin, H. & Dickie, B. R., 23 Jan 2025, (Accepted/In press) In: npj Imaging.Research output: Contribution to journal › Article › peer-review
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Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci
Shi, C., Zhao, D., Butler, J., Frantzeskos, A., Rossi, S., Ding, J., Ferrazzano, C., Wynn, C., Hum, R. M., Richards, E., Gupta, M., Patel, K., Yap, C. F., Plant, D., Grencis, R., Martin, P., Adamson, A., Eyre, S., Bowes, J. & Barton, A. & 3 others, , 10 Feb 2025, In: Genome Biology. 26, 1, 26.Research output: Contribution to journal › Article › peer-review
Open Access -
The glomerular circadian clock temporally regulates basement membrane dynamics and the podocyte glucocorticoid response
Preston, R., Chrisp, R., Dudek, M., Paiva Teixeira Morais, M., Tian, P., Williams, E., Naylor, R., Davenport, B., Pathiranage, D., Benson, E., Spiller, D., Bagnall, J., Zeef, L., Lawless, C., Baker, S. M., Meng, Q.-J. & Lennon, R., Jan 2025, In: Kidney International. 107, 1, p. 99-115Research output: Contribution to journal › Article › peer-review
Open Access -
The level of HAND1 controls the specification of multipotent cardiac and extraembryonic progenitors from human pluripotent stem cells
Lynch, A., Phillips, N., Douglas, M., Dorgnach, M., Lin, I.-H., Adamson, A., Darieva, Z., Whittle, J., Hanley, N., Bobola, N. & Birket, M. (Lead), 10 Feb 2025, (Accepted/In press) In: EMBO Journal.Research output: Contribution to journal › Article › peer-review
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Ubiquitous MEIS transcription factors actuate lineage-specific transcription to establish cell fate
Darieva, Z., Zarrineh, P., Phillips, N., Mallen, J., Garcia Mora, A., Donaldson, I., Bridoux, L., Douglas, M., Henriques, S., Schulte, D., Birket, M. (Corresponding) & Bobola, N. (Lead), 31 Jan 2025, (Accepted/In press) In: EMBO Journal.Research output: Contribution to journal › Article › peer-review
1 Downloads (Pure) -
2024
Activation of the aryl hydrocarbon receptor via indole derivatives is a common feature in skin bacterial isolates
Elias, A., Mcbain, A., Aldehalan, F. A. A., Taylor, G. & O'Neill, C., 23 Oct 2024, In: Journal of Applied Microbiology. 135, 11Research output: Contribution to journal › Article › peer-review
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Activation of the integrated stress response in human hair follicles
Pye, D., Scholey, R., Ung, S., Dawson, M., Shahmalak, A. & Purba, T. S., 20 Jun 2024, In: PLoS ONE. 19, 6, e0303742.Research output: Contribution to journal › Article › peer-review
Open Access -
A novel integrated extraction protocol for multi-omic studies in heavily degraded samples
Boggi, B., Sharpen, J. D. A., Taylor, G. & Drosou, K., 30 Jul 2024, In: Scientific Reports. 14, 1, 17477.Research output: Contribution to journal › Article › peer-review
Open Access -
A secreted proteomic footprint for stem cell pluripotency
Lewis, P. A., Silajdžić, E., Smith, H., Bates, N., Smith, C. A., Mancini, F. E., Knight, D., Denning, C., Brison, D. R. & Kimber, S. J., 14 Jun 2024, (E-pub ahead of print) In: PLoS ONE. 19, 6Research output: Contribution to journal › Article › peer-review
Open Access -
A systematic review of normal tissue neurovascular unit damage following brain irradiation-Factors affecting damage severity and timing of effects
Nakkazi, A., Forster, D., Whitfield, G. A., Dyer, D. P. & Dickie, B. R., 13 Jun 2024, In: Neuro-Oncology Advances. 6, 1, vdae098.Research output: Contribution to journal › Article › peer-review
Open Access -
Bacterial aggregation facilitates internalin-mediated invasion of Listeria monocytogenes.
Feltham, L., Moran, J., Goldrick, M., Lord, E., Spiller, D. G., Cavet, J. S., Muldoon, M., Roberts, I. S. & Paszek, P., 9 Jul 2024, (E-pub ahead of print) In: Frontiers in cellular and infection microbiology. 14, 1411124.Research output: Contribution to journal › Article › peer-review
Open Access -
Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility
Tikhomirov, R., Oakley, R. H., Anderson, C., Xiang, Y., Al-Othman, S., Smith, M., Yaar, S., Torre, E., Li, J., Wilson, L. R., Goulding, D. R., Donaldson, I., Harno, E., Soattin, L., Shiels, H. A., Morris, G. M., Zhang, H., Boyett, M. R., Cidlowski, J. A. & Mesirca, P. & 2 others, , 10 May 2024, In: Circulation research. 134, 10, p. 1306-1326 21 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Corrigendum to "Optimising a self-assembling peptide hydrogel as a Matrigel alternative for 3-dimensional mammary epithelial cell culture" [Biomater. Adv. volume 160, (2024) 213847]
Lingard, E., Dong, S., Hoyle, A., Appleton, E., Hales, A., Skaria, E., Lawless, C., Taylor-Hearn, I., Saadati, S., Chu, Q., Miller, A. F., Domingos, M., Saiani, A., Swift, J. & Gilmore, A. P., 18 Nov 2024, (E-pub ahead of print) In: Biomaterials Advances. p. 214111Research output: Contribution to journal › Article › peer-review
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Cretaceous climate change evidenced in the Senegalese rock record, NW Africa
Pearson, M., Casson, M., Millar, I., Charton, R. & Redfern, J., 1 Mar 2024, In: Journal of African Earth Sciences. 211, 19 p., 105166.Research output: Contribution to journal › Article › peer-review
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Deciphering molecular drivers of lactate metabolic shift in mammalian cell cultures
Torres, M., Hawke, E., Hoare, R., Scholey, R., Pybus, L. P., Young, A., Hayes, A. & Dickson, A. J., 1 Mar 2025, In: Metabolic Engineering. 88, p. 25-39 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Detection of Mismatch Repair Deficiency in Endome-Trial Cancer: Assessment of IHC, Fragment Length Analysis, and Amplicon Sequencing Based MSI Testing
Sowter, P., Gallon, R., Hayes, C., Phelps, R., Borthwick, G., Prior, S., Combe, J., Buist, H., Pearlman, R., Hampel, H., Goodfellow, P., Evans, G., Crosbie, E., Ryan, N., Burn, J., Santibanez-Koref, M. & Jackson, M. S., Nov 2024, In: Cancers.Research output: Contribution to journal › Article › peer-review
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Effect of a retinoic acid analogue on BMP-driven pluripotent stem cell chondrogenesis
Mancini, F., Humphreys, P. E., Woods, S., Bates, N., Cuvertino, S., O'Flaherty, J., Biant, L., Domingos, M. & Kimber, S., 1 Feb 2024, In: Scientific Reports. 14, 2696.Research output: Contribution to journal › Article › peer-review
Open Access -
Epithelial uptake leads to fungal killing in vivo and is aberrant in COPD-derived epithelial cells
Bertuzzi, M., Howell, G., Thomson, D., Fortune-Grant, R., Möslinger, A., Dancer, P., Van Rhijn, N., Motsi, N., Codling, A. & Bignell, E., 21 Jun 2024, In: iScience. 27, 6, 109939.Research output: Contribution to journal › Article › peer-review
Open Access -
Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis
Downton, P., Dickson, S. H., Ray, D. W., Bechtold, D. A. & Gibbs, J. E., 10 Jul 2024, In: Open Biology. 14, 7, 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival
Haley, M. J., Bere, L., Minshull, J., Georgaka, S., Garcia-Martin, N., Howell, G., Coope, D. J., Roncaroli, F., King, A., Wedge, D. C., Allan, S. M., Pathmanaban, O. N., Brough, D. & Couper, K. N., 17 May 2024, In: Science Advances. 10, 20, eadj3301.Research output: Contribution to journal › Article › peer-review
Open Access -
IL23R mutations associated with decreased risk of psoriasis lead to the differential expression of genes implicated in the disease
Rane, S., Eyre, S., Adamson, A. & Shellard, E., 22 Sept 2024, In: Experimental Dermatology. 33, 9, e15180.Research output: Contribution to journal › Article › peer-review
Open Access -
Impact of inter-species hybridisation on antifungal drug response in the Saccharomyces genus
Visinoni, F., Royle, W., Scholey, R., Hu, Y., Timouma, S., Zeef, L., Louis, E. J. & Delneri, D., 2 Dec 2024, In: BMC Genomics. 25, 1, p. 1165Research output: Contribution to journal › Article › peer-review
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Intrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation
Coulson-Gilmer, C., Littler, S., Barnes, B., Brady, R., Anagho, H. A., Pillay, N., Dey, M., Macmorland, W., Bronder, D., Nelson, L., Tighe, A., Lin, W.-H., Morgan, R., Unwin, R., Nielsen, M. L., Mcgrail, J. & Taylor, S., 16 Jul 2024, In: NAR cancer. 6, 3, zcae030.Research output: Contribution to journal › Article › peer-review
Open Access -
Kidney resident macrophages have distinct subsets and multifunctional roles
Chew, C., Brand, O. J., Yamamura, T., Lawless, C., Morais, M. R. P. T., Zeef, L., Lin, I.-H., Howell, G., Lui, S., Lausecker, F., Jagger, C., Shaw, T. N., Krishnan, S., McClure, F. A., Bridgeman, H., Wemyss, K., Konkel, J. E., Hussell, T. & Lennon, R., Mar 2024, In: Matrix biology : journal of the International Society for Matrix Biology. 127, p. 23-37 15 p.Research output: Contribution to journal › Article › peer-review
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Lymphatic network drainage resolves cerebral oedema and facilitates recovery from experimental cerebral malaria
Haley, M., Barroso, R., Jasim, D., Haigh, M., Green, J., Dickie, B., Craig, A., Brough, D. & Couper, K., 28 May 2024, In: Cell Reports. 43, 5, 114217.Research output: Contribution to journal › Article › peer-review
Open Access -
Neuroinflammation and blood-brain barrier breakdown in acute, clinical intracerebral hemorrhage
Jones, O., Mohamed, S., Hinz, R., Paterson, A., Sobowale, O., Dickie, B., Parkes, L. & Parry-Jones, A., 3 Oct 2024, (E-pub ahead of print) In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X241274685.Research output: Contribution to journal › Article › peer-review
Open Access -
Physiotherapists' Experiences and Perceived Acceptability of Delivering a Knee Bracing Intervention for People With Symptomatic Knee Osteoarthritis in a Randomised Trial (PROP OA): A Qualitative Study
Bullock, L., Holden, M. A., Jinks, C., Atiah Asamane, E., Herron, D., Borrelli, B., Callaghan, M. J., Birrell, F., Halliday, N., Marshall, M., Sowden, G., Ingram, C., McBeth, J., Dziedzic, K., Foster, N. E., Jowett, S., Lawton, S., Mallen, C. D. & Peat, G., Dec 2024, In: Musculoskeletal care. 22, 4, p. e70021Research output: Contribution to journal › Article › peer-review
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Prediction, screening and characterization of novel bioactive tetra-peptide matrikines for skin rejuvenation
Jariwala, N., Ozols, M., Eckersley, A., Mambwe, B., Watson, R. E. B., Zeef, L., Gilmore, A., Debelle, L., Bell, M., Bradley, E. J., Doush, Y., Keenan, A., Courage, C., Leroux, R., Peschard, O., Mondon, P., Ringenbach, C., Bernard, L., Pitois, A. & Sherratt, M. J., 22 Apr 2024, In: The British journal of dermatology.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteolysis of tau by granzyme A in tauopathies generates fragments that are aggregation prone
Quinn, J. P., Fisher, K., Corbett, N., Warwood, S., Knight, D., Kellett, K. A. B. & Hooper, N. M., 18 Sept 2024, In: Biochemical Journal. 481, 18, p. 1255-1274 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteomic profiling of kidney biopsies in nephrotic syndrome [version 1; peer review: 1 approved]
Williams, E., Fresquet, M., Lawless, C., Knight, D., Colby, E., Watson, J., Welsh, G. I., Saleem, M. A., Lennon, R. & Elizabeth, C., 24 Dec 2024, In: Wellcome open research.Research output: Contribution to journal › Article › peer-review
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Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions
Wellens, R., Tapia , V., Seoane Denicola, P., Bennett, H., Adamson, A., Coutts, G., Rivers-Auty, J., Lowe, M., Green, J., Lopez-Castejon, G., Brough, D. & Hoyle, C., 8 Aug 2024, In: Nature Communications. 15, 6750.Research output: Contribution to journal › Article › peer-review
Open Access -
Solar urticaria involves rapid mast cell STAT3 activation and neutrophil recruitment, with FcεR1 as an upstream regulator
Rutter, K. J., Peake, M., Hawkshaw, N. J., Scholey, R., Bulfone-Paus, S., Friedmann, P. S., Farrar, M. D. & Rhodes, L. E., 4 Jan 2024, (E-pub ahead of print) In: The Journal of allergy and clinical immunology.Research output: Contribution to journal › Article › peer-review
Open Access -
The generation and validation of two NKX2-5 fluorescent reporter human embryonic stem cell lines: UMANe002-A-1 and UMANe002-A-2
Douglas, M., O'Loughlin, C., Lynch, A., Prialgauskaite, R., Adamson, A., Dibb, K., Kimber, S. & Birket, M., 1 Feb 2024, In: Stem Cell Research. 74, 103262.Research output: Contribution to journal › Article › peer-review
Open Access -
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix
Shah, A., Zhang, X., Snee, M., Lockhart-Cairns, M. P., Levy, C. W., Jowitt, T. A., Birchenough, H. L., Dean, L., Collins, R., Dodd, R. J., Roberts, A. R. E., Enghild, J. J., Mantovani, A., Fontana, J., Baldock, C., Inforzato, A., Richter, R. P. & Day, A. J., 1 Apr 2025, In: Matrix biology : journal of the International Society for Matrix Biology. 136, p. 52-68Research output: Contribution to journal › Article › peer-review
Open Access -
The Tmem16a chloride channel is required for mucin maturation after secretion from goblet-like cells in the Xenopus tropicalis tadpole skin
Dubaissi, E., Hilton, E., Lilley, S., Collins, R., Holt, C., March, P., Danahay, H., Gosling, M., Grencis, R., Roberts, I. & Thornton, D., 26 Oct 2024, In: Scientific Reports. 14, 25555.Research output: Contribution to journal › Article › peer-review
Open Access -
Transcriptomic profiling reveals key early response genes during GDF6-mediated differentiation of human adipose-derived stem cells to nucleus pulposus cells
Gilbert, H. T. J., Wignall, F. E. J., Zeef, L., Hoyland, J. A. & Richardson, S. M., Mar 2024, In: JOR Spine. 7, 1, p. e1315Research output: Contribution to journal › Article › peer-review
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Tumor circadian clock strength influences metastatic potential and predicts patient prognosis in luminal A breast cancer
Li, S.-Y., Hammarlund, J. A., Wu, G., Lian, J.-W., Howell, S. J., Clarke, R. B., Adamson, A. D., Gonçalves, C. F., Hogenesch, J. B., Anafi, R. C. & Meng, Q.-J., 6 Feb 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 7, p. e2311854121Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Downloads (Pure) -
Use of over-the-counter supplements, sleep aids, and analgesic medicines in rheumatology: results of a cross-sectional survey
Soomro, M., Lyons, S., Bravo, R., Mcbeth, J., Lunt, M., Dixon, W. & Jani, M., 9 Oct 2024, (E-pub ahead of print) In: Rheumatology Advances in Practice .Research output: Contribution to journal › Article › peer-review
Open Access -
2023
A community-endorsed open-source lexicon for contrast-agent based perfusion MRI (CAPLEX): A consensus guidelines report from the ISMRM Open Science Initiative for Perfusion Imaging (OSIPI)
Dickie, B. R., Ahmed, Z., Arvidsson, J., Bell, L. C., Buckley, D. L., Debus, C., Fedorov, A., Floca, R., Gutmann, I., van der Heijden, R. A., van Houdt, P. J., Sourbron, S., Thrippleton, M. J., Quarles, C. & Kompan, I. N., 13 Oct 2023, In: Magnetic Resonance in Medicine.Research output: Contribution to journal › Article › peer-review
Open Access -
A pipeline to identify transcription factor combinatorial binding uncovers TEAD1 as an antagonist of tissue-specific transcription factors in human organogenesis
Garcia Mora, A., Mallen, J., Zarrineh, P., Hanley, N., Gerrard, D. T. & Bobola, N., 7 Oct 2023, In: bioRxiv.Research output: Contribution to journal › Article
Open Access -
A rare human variant that disrupts GPR10 signalling causes weight gain in mice
Talbot, F., Feetham, C. H., Mokrosiński, J., Lawler, K., Keogh, J. M., Henning, E., Mendes de Oliveira, E., Ayinampudi, V., Saeed, S., Bonnefond, A., Arslan, M., Yeo, G. S. H., Froguel, P., Bechtold, D. A., Adamson, A., Humphreys, N., Barroso, I., Luckman, S. M. & Farooqi, I. S., 15 Mar 2023, In: Nature Communications. 14, 1, 1450.Research output: Contribution to journal › Article › peer-review
Open Access -
A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2.
Losa, M., Barozzi, M., Osterwalder, M., Zarrineh, P., Benazet, J., Chacon, B., Girdziusaite, A., Morabito, A., Zhu, J., Mackem, S., Capellini, D., Bobola, N., Dickel, D., Visel, A., Zeller, R. & Selleri, L., 1 Dec 2023, In: Nature Communications. 14, 1, 3993.Research output: Contribution to journal › Article › peer-review
Open Access -
Aspergillus fumigatus Can Display Persistence to the Fungicidal Drug Voriconazole
Scott, J., Valero, C., Mato-López, Á., Donaldson, I. J., Roldán, A., Chown, H., Van Rhijn, N., Lobo-Vega, R., Gago, S., Furukawa, T., Morogovsky, A., Ben Ami, R., Bowyer, P., Osherov, N., Fontaine, T., Goldman, G. H., Mellado, E., Bromley, M. & Amich, J., 13 Mar 2023, In: Microbiology spectrum. e0477022.Research output: Contribution to journal › Article › peer-review
Open Access -
Bcl6 is a subset defining transcription factor of Lymphoid Tissue inducer-like ILC3
Tachó Piñot, R., Stamper, C. T., King, J., Matei-Rascu, V., Richardson, E., Li, Z., Roberts, L. B., Bassett, J. W., Melo Gonzalez, F., Fiancette, R., Lin, I.-H., Dent, A., Harada, Y., Finlay, C., Mjösberg, J., Withers, D. R. & Hepworth, M., 28 Nov 2023, In: Cell Reports. 42, 11, 113425.Research output: Contribution to journal › Article › peer-review
Open Access