Adam Greenstein

2025

Combining In Vivo Two‐Photon and Laser Speckle Microscopy With the Ex Vivo Capillary‐Parenchymal Arteriole Preparation as a Novel Approach to Study Neurovascular Coupling

Evans, L. E., Gray, A. L., Walsh, K. R., Danby, T. G. E., Pritchard, H. A. T., Allan, S. M., Gurney, A. M., Greenstein, A. S. & Schiessl, I., 7 Jan 2025, In: Microcirculation. 32, 1, e70001.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Acute, pro‐contractile effects of prorenin on rat mesenteric arteries

Rognant, S., Baldwin, S. N., Pritchard, H. A. T., Greenstein, A., Calloe, K., Aalkjaer, C. & Jepps, T. A., 1 Dec 2023, In: The FASEB Journal. 37, 12, e23282.

Research output: Contribution to journal › Article › peer-review

Open Access

A Multi-disciplinary Commentary on Preclinical Research to investigate Vascular Contributions to Dementia

Sri, S., Greenstein, A., Granata, A., Collcutt, A., Jochems, A. C. C., Mccoll, B. W., Castro, B. D., Webber, C., Reyes, C. A., Hall, C., Lawrence, C., Hawkes, C., Pegasiou-Davies, C.-M., Gibson, C., Crawford, C. L., Smith, C., Vivien, D., Mclean, F. H., Wiseman, F. & Brezzo, G. & 37 others, Lalli, G., Pritchard, H., Markus, H. S., Bravo-Ferrer, I., Taylor, J., Leiper, J., Berwick, J., Gan, J., Gallacher, J., Moss, J., Goense, J., Mcmullan, L., Work, L., Evans, L., Stringer, M. S., Ashford, M., Abulfadl, M., Conlon, N., Malhotra, P., Bath, P., Canter, R., Brown, R., Ince, S., Anderle, S., Young, S., Quick, S., Szymkowiak, S., Hill, S., Allan, S., Wang, T., Quinn, T., Procter, T., Farr, T. D., Zhao, X., Yang, Z., Hainsworth, A. H. & Wardlaw, J. M., 30 Oct 2023, In: Cerebral Circulation - Cognition and Behavior. 5, 100189.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Downloads (Pure)

Uncoupling of Ca 2+ sparks from BK channels in cerebral arteries underlies hypoperfusion in hypertension-induced vascular dementia.

Taylor, J. L., Walsh, K. R., Mosneag, I.-E., Danby, T. G. E., Luka, N., Chanda, B., Schiessl, I., Dunne, R. A., Hill-Eubanks, D., Hennig, G. W., Allan, S. M., Nelson, M. T., Greenstein, A. S. & Pritchard, H. A. T., 15 Aug 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 33, e2307513120.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer's disease

Taylor, J. L., Pritchard, H. A. T., Walsh, K. R., Strangward, P., White, C., Hill-Eubanks, D., Alakrawi, M., Hennig, G. W., Allan, S. M., Nelson, M. T. & Greenstein, A. S., 28 Jun 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 26, p. e2204581119

Research output: Contribution to journal › Article › peer-review

Macro- and Microvascular Function in Middle-Aged Individuals with Low Cardiovascular Disease Risk

Patel, S., Shokr, H., Greenstein, A. & Gherghel, D., 25 Nov 2022, In: Journal of Clinical Medicine. 11, 23, 6962.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Cardiovascular co-morbidities, inflammation and cerebral small vessel disease

Evans, L., Taylor, J., Smith, C., Pritchard, H., Greenstein, A. & Allan, S., 2021, In: Cardiovascular research.

Research output: Contribution to journal › Article › peer-review

Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease

Koide, M., Harraz, O. F., Dabertrand, F., Longden, T. A., Ferris, H. R., Wellman, G. C., Hill-Eubanks, D. C., Greenstein, A. S. & Nelson, M. T., 15 Sept 2021, In: The Journal of clinical investigation. 131, 18

Research output: Contribution to journal › Article › peer-review

Kynurenine Relaxes Arteries of Normotensive Women and Those with Preeclampsia

Worton, S. A., Pritchard, H. A., Greenwood, S. L., Alakrawi, M., Heazell, A. E., Wareing, M., Greenstein, A. S. & Myers, J. E., 3 Mar 2021, In: Circulation research.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Cardiac complex II activity is enhanced by fat and mediates greater mitochondrial oxygen consumption following hypoxic re-oxygenation

Zhu, S. C., Chen, C., Wu, Y. N., Ahmed, M., Kitmitto, A., Greenstein, A. S., Kim, S. J., Shao, Y. F. & Zhang, Y. H., 1 Mar 2020, In: Pflugers Archiv European Journal of Physiology. 472, 3, p. 367-374 8 p.

Research output: Contribution to journal › Article › peer-review

Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney

Jiang, X., Eales, J. M., Scannali, D., Nazgiewicz, A., Prestes, P., Maier, M., Denniff, M., Xu, X., Saluja, S., Cano-Gamez, E., Wystrychowski, W., Szulinska, M., Antczak, A., Byars, S., Skrypnik, D., Glyda, M., Król, R., Zywiec, J., Zukowska-Szczechowska, E. & Burrell, L. M. & 13 others, Woolf, A. S., Greenstein, A., Bogdanski, P., Keavney, B., Morris, A. P., Heagerty, A., Williams, B., Harrap, S. B., Trynka, G., Samani, N. J., Guzik, T. J., Charchar, F. J. & Tomaszewski, M., 27 Oct 2020, In: European Heart Journal . 41, 48, p. 4580-4588 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

‘A Step and a Ceiling’: Mechanical properties of Ca2+ spark vasoregulation in resistance arteries by pressure-induced oxidative activation of PKG

Csato, V., Syed Abdul Kadir, S. Z., Khavandi, K., Bennett, H., Sugden, S., Gurney, A., Pritchard, H., Hill-Eubanks, D., Eaton, P., Nelson, M. & Greenstein, A., 2020, In: Physiological Reports. 7, 22, p. 1-12 12 p., e14260.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Disruption of Pressure-Induced Ca2+ Spark Vasoregulation of Resistance Arteries, Rather Than Endothelial Dysfunction, Underlies Obesity-Related Hypertension

Greenstein, A. S., Kadir, S. Z. A. S., Csato, V., Sugden, S. A., Baylie, R. A., Eisner, D. A. & Nelson, M. T., 23 Dec 2019, In: Hypertension (Dallas, Tex. : 1979).

Research output: Contribution to journal › Article › peer-review

Open Access

Engaging parents using web-based feedback on child growth to reduce childhood obesity: a mixed methods study

Dam, R., Robinson, H., Vince-Cain, S., Heaton, G., Greenstein, A., Sperrin, M. & Hassan, L., 2019, In: B M C Public Health.

Research output: Contribution to journal › Article › peer-review

Open Access

May Measurement Month 2017: an analysis of blood pressure screening results from the United Kingdom and the Republic of Ireland-Europe

International Society of Hypertension and British and Irish Hypertension Society, 24 Apr 2019, In: European Heart Journal. Supplements. 21, Suppl D, p. D121-D123

Research output: Contribution to journal › Article › peer-review

Open Access

Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility

Pritchard, H. A. T., Griffin, C. S., Yamasaki, E., Thakore, P., Lane, C., Greenstein, A. S. & Earley, S., 22 Oct 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 43, p. 21874-21881 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Abnormal Remodeling of Subcutaneous Small Arteries Is Associated With Early Diastolic Impairment in Metabolic Syndrome

Khavandi, K., Aghamohammadzadeh, R., Luckie, M., Brownrigg, J., Alam, U., Khattar, R., Malik, R. A., Heagerty, A. M. & Greenstein, A. S., 11 Apr 2017, In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 6, 4, e004603.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response

Scotcher, J., Prysyazhna, O., Boguslavskyi, A., Kistamas, K., Hadgraft, N., Martin, E. D., Worthington, J., Rudyk, O., Rodriguez Cutillas, P., Cuello, F., Shattock, M. J., Marber, M. S., Conte, M. R., Greenstein, A., Greensmith, D. J., Venetucci, L., Timms, J. F. & Eaton, P., 26 Oct 2016, In: Nature Communications. 7, p. 13187

Research output: Contribution to journal › Article › peer-review

Open Access

Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels

Khavandi, K., Baylie, R. L., Sugden, S. A., Ahmed, M., Csato, V., Eaton, P., Hill-Eubanks, D. C., Bonev, A. D., Nelson, M. T. & Greenstein, A. S., 2016, In: Science Signaling. 9, 449, p. ra100

Research output: Contribution to journal › Article › peer-review

Open Access

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101 Downloads (Pure)

2015

Effects of Obesity on Perivascular Adipose Tissue Vasorelaxant Function: Nitric Oxide, Inflammation and Elevated Systemic Blood Pressure

Aghamohammadzadeh, R., Unwin, R. D., Greenstein, A. S. & Heagerty, A. M., 25 Feb 2015, In: Journal of Vascular Research. 52, 5, p. 299-305 7 p.

Research output: Contribution to journal › Article › peer-review

2014

Adiponectin Induces A20 Expression in Adipose Tissue To Confer Metabolic Benefit.

Hand, L., Usan, P., Cooper, G. J. S., Xu, L. Y., Ammori, B., Cunningham, P., Aghamohammadzadeh, R., Soran, H., Greenstein, A., Loudon, A. S. I., Bechtold, D. A. & Ray, D., 4 Sept 2014, In: Diabetes. 64, p. 128-136 8 p.

Research output: Contribution to journal › Article › peer-review

Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea

Yadav, R., France, M., Aghamohammadzadeh, R., Liu, Y., Hama, S., Kwok, S., Schofield, J., Turkington, P., Syed, A. A., Malik, R., Pemberton, P., Greenstein, A., Durrington, P., Ammori, B., Gibson, M., Jeziorska, M. & Soran, H., 1 Sept 2014, In: Journal of Clinical Endocrinology and Metabolism. 99, 9, p. 3390-3398 8 p.

Research output: Contribution to journal › Article › peer-review

2013

Effects of bariatric surgery on human small artery function: evidence for reduction in perivascular adipocyte inflammation, and the restoration of normal anticontractile activity despite persistent obesity

Aghamohammadzadeh, R., Greenstein, A. S., Yadav, R., Jeziorska, M., Hama, S., Soltani, F., Pemberton, P. W., Ammori, B., Malik, R. A., Soran, H. & Heagerty, A. M., 9 Jul 2013, In: Journal of American College of Cardiology. 62, 2, p. 128-135 8 p.

Research output: Contribution to journal › Article › peer-review

Retinal arterial hypertrophy: The new LVH?

Khavandi, K., Arunakirinathan, M., Greenstein, A. S. & Heagerty, A. M., Jun 2013, In: Current Hypertension Reports. 15, 3, p. 244-252 8 p.

Research output: Contribution to journal › Article › peer-review

2012

Interrupting the Natural History of Diabetes Mellitus: Lifestyle, Pharmacological and Surgical Strategies Targeting Disease Progression.

Khavandi, K., Brownirgg, J., Hankir, M., Sood, H., Younis, N., Worth, J., Greenstein, A., Soran, H., Wierzbicki, A. & Goldsmith, D. J., 20 Jan 2012, In: Current vascular pharmacology.

Research output: Contribution to journal › Article › peer-review

Perivascular adipose tissue from human systemic and coronary vessels: The emergence of a new pharmacotherapeutic target

Aghamohammadzadeh, R., Withers, S., Lynch, F., Greenstein, A., Malik, R. & Heagerty, A., 10 Jan 2012, In: British Journal of Pharmacology. 165, 3, p. 670-682 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Relationship of endothelial function and atherosclerosis to treatment response in late-life depression

Paranthaman, R., Greenstein, A., Burns, A. S., Heagerty, A. M., Malik, R. A. & Baldwin, R. C., Sept 2012, In: International journal of geriatric psychiatry. 27, 9, p. 967-973 6 p.

Research output: Contribution to journal › Article › peer-review

2011

Mutation in the beta adducin subunit causes tissue-specific damage to myogenic tone

Sonoyama, K., Greenstein, A. S., Micheletti, R., Ferrari, P., Schiavone, A., Aghamohammadzadeh, R., Withers, S. B., Tripodi, G., Ferrandi, M. & Heagerty, A. M., Mar 2011, In: Journal of hypertension. 29, 3, p. 466-474 8 p.

Research output: Contribution to journal › Article › peer-review

2010

Small-dense LDL and LDL glycation in metabolic syndrome and in statin-treated and non-statin-treated type 2 diabetes

Younis, N. N., Soran, H., Sharma, R., Charlton-Menys, V., Greenstein, A., Elseweidy, M. M. & Durrington, P. N., Oct 2010, In: Diabetes and Vascular Disease Research. 7, 4, p. 289-295 6 p.

Research output: Contribution to journal › Article › peer-review

2009

Diabetic cardiomyopathy

Asghar, O., Al-Sunni, A., Khavandi, K., Khavandi, A., Withers, S., Greenstein, A., Heagerty, A. M. & Malik, R. A., May 2009, In: Clinical Science. 116, 10, p. 741-60 20 p.

Research output: Contribution to journal › Article › peer-review

Diabetic cardiomyopathy - a distinct disease?

Khavandi, K., Khavandi, A., Asghar, O., Greenstein, A., Withers, S., Heagerty, A. M. & Malik, R. A., Jun 2009, In: Best Practice and Research: Clinical Endocrinology and Metabolism. 23, 3, p. 347-360 13 p.

Research output: Contribution to journal › Article › peer-review

Eutrophic remodeling of small arteries in type 1 diabetes mellitus is enabled by metabolic control: a 10-year follow-up study

Greenstein, A. S., Price, A., Sonoyama, K., Paisley, A., Khavandi, K., Withers, S., Shaw, L., Paniagua, O., Malik, R. A. & Heagerty, A. M., Jul 2009, In: Hypertension. 54, 1, p. 134-41 8 p.

Research output: Contribution to journal › Article › peer-review

2007

Chronic complications of diabetes: Risk factors and interventions

Greenstein, A., Mojaddidi, M., Al-Sunni, A., Tavakoli, M. & Malik, R., 2007, In: MIMS Cardiovascular. 2

Research output: Contribution to journal › Article › peer-review

Microvascular complications: Evaluation and monitoring relevance to clinical practice, clinical trials, and drug development

Greenstein, A., Tavakoli, M., Mojaddidi, M., Al-Sunni, A., Matfin, G. & Malik, R. A., Jul 2007, In: British Journal of Diabetes and Vascular Disease. 7, 4, p. 166-171 5 p.

Research output: Contribution to journal › Article › peer-review

Vascular remodeling: Implications for small artery function and target organ damage

Sonoyama, K., Greenstein, A., Price, A., Khavandi, K., Heagerty, T. & Heagerty, A., 2007, In: Therapeutic Advances in Cardiovascular Disease. 1, 2, p. 129-137 8 p.

Research output: Contribution to journal › Article › peer-review

2006

Glycaemic control in south Asian patients during feasting and fasting

Asghar, O., Greenstein, A. & Malik, R. A., Oct 2006, In: British journal of hospital medicine. 67, 10, p. 523-526 3 p.

Research output: Contribution to journal › Article › peer-review

2005

Acute neuropathic joint disease: A medical emergency?

Tan, A. L., Greenstein, A., Jarrett, S. J. & McGonagle, D., 2005, In: Diabetes Care. 28, 12, p. 2962-2964 2 p.

Research output: Contribution to journal › Article › peer-review

2002

Magnetic resonance imaging as a predictor of progressive joint destruction in neuropathic joint disease

Greenstein, A. S., Marzo-Ortega, H., Emery, P., O'Connor, P. & McGonagle, D., 1 Oct 2002, In: Arthritis Care & Research. 46, 10, p. 2814-2816 2 p.

Research output: Contribution to journal › Article › peer-review

Adam Greenstein, BSc(Hons) MBChB MRCP PhD

Research output

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