Personal profile

Biography

2010 - present

Academic staff, currently Reader,  University of Manchester, Faculty of Life Sciences and then Faculty of Biology, Medicine and Health

2004 - 2010

Cancer Research UK Career Development Fellow, University of Manchester

1999-2004

Post-doctoral research associate with Hans Clevers, Academic Hospital Utrecht and Hubrecht Laboratories, The Netherlands

1998

PhD University of Glasgow, Faculty of Medicine. Research performed at Beatson laboratories under the supervison of Dr Donald M. Black

Research interests

Currently, my laboratory investigates how to harness T cells to eradicate cancer. On the one hand, we investigate adaptive resistance to immune checkpoint inhibitors, a class of drugs that reinvigorate T cells that have become dysfunctional in cancers. Sometimes this dysfunction appears in response to therapy (adaptive resistance) and our aim is to reverse this in order to preserve a clinical response. We are also engineering naive T cells to react to tumour antigens by providing them with novel antigen receptors. Again these engineered T cells may become inactive after being inside the tumour microenvironment and we are investigating how to overcome this obstacle too.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, The Beatson Institute for Cancer Research

Oct 1994Sept 1998

Award Date: 14 Aug 1998

Bachelor of Arts, Natural Sciences, University of Cambridge

Oct 1990Jun 1994

Award Date: 30 Jun 1994

Research Beacons, Institutes and Platforms

  • Lydia Becker Institute

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Collaborations and top research areas from the last five years

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