Research output per year
Research output per year
Personal profile
Research interests
I am interested in the field of phosphoinositides and the enzymes regulating their synthesis and degradation as well as how their dysregulation could lead to different illnesses.
Overview
I am a research scientist, who enjoys employing state-of-the-art research techniques to explore and understand the participation of genes and their products in the functions of living cells as well as how defects in cellular processes can lead to disease. My current research focuses on the interplay between B cell receptor signaling and the actin cytoskeleton during B cell activation.
Education/Academic qualification
Doctor of Philosophy, University of Cambridge
Keywords
- Immune cell biology
- B cell receptor signaling
- Endocytic trafficking
- Inositol Polyphosphate 5-Phosphatases
- Phosphoinositides
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Research output
- 4 Article
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The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling
Droubi, A., Wallis, C., Anderson, K. E., Rahman, S., de Sa, A., Rahman, T., Stephens, L. R., Hawkins, P. T. & Lowe, M., 5 Sep 2022, In: The Journal of cell biology. 221, 9, e202112018.Research output: Contribution to journal › Article › peer-review
Open Access -
In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling
Bulley, S. J., Droubi, A., Clarke, J. H., Anderson, K. E., Stephens, L. R., Hawkins, P. T. & Irvine, R. F., 20 Sep 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 38, p. 10571-10576 6 p.Research output: Contribution to journal › Article › peer-review
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Nuclear localizations of phosphatidylinositol 5-phosphate 4-kinases α and β are dynamic and independently regulated during starvation-induced stress.
Droubi, A., Bulley, S. J., Clarke, J. H. & Irvine, R. F., 2016, In: The Biochemical Journal. 473, 14, p. 2155-2163Research output: Contribution to journal › Article › peer-review
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Exploring phosphatidylinositol 5-phosphate 4-kinase function.
Bulley, S. J., Clarke, J. H., Droubi, A., Giudici, M-L. & Irvine, R. F., 2015, In: Advances in Biological Regulation. 57, p. 193-202 10 p.Research output: Contribution to journal › Article › peer-review