Personal profile

Biography

  • I was appointed to the University of Manchester in 1993and was appointed as chair in Neuroradiology in September 1995. Prior to this I was a full time NHS clinical neuroradiologist at the Manchester Royal Infirmary
  • I became Professor of Radiology in 2003 as my research interests became more generalised in the area of cancer imaging.
  • In 2013 I established the CRUK / EPSRC Cancer Imaging Center in Cambridge and Manchester with Colleagues Geoff Parker from Manchester and Kevin Brindle, Fiona Gilbert and Carlos Caldas from Cambridge
  • I have honorary clinical consultant contracts at the Salford Hospitals NHS Trust and the Manchester Royal Infirmary
  • I was appointed as Director of the Wolfson Molecular Imaging Center in 2008.
  • My wife Susan is an anaesthetist and Intensivist and we have two children. Theodore and Alexandra

Research interests

My research interests have developed from a single objective to optimize the use of modern clinical imaging systems for diagnosis, classification and therapeutic planning.   I have been extensively involved in research related to the use of MRI in Cancer drug development and the development of imaging biomarkers for use in early phase clinical trials.

 

Much of my research is centred on the development and validation of novel imaging biomarkers for use in research and clinical applications.


 

My major areas of clinical research interest are:

  • Neurooncology.
  • Systemic cancer.
  • Microvascular brain disease

My research group is largely focused on methodlogical developments around image analysis with special interests in:

  • Identification, validation and translation of imaging biomarkers for both clinical application and trial studies within my clinical areas of interest.
  •  Identification of the physiological/pathological import of individual imaging biomarkers in research and clinical application.

Links:

 CRUK/EPSRC cancer imaging centre in Cambridge and Manchester

http://research.bmh.manchester.ac.uk/imagingfacilities/CIC

 

I am committed to providing access to novel techniques and biomarkers. As such many of the advanced image analysis approaches which we have developed and described in our publications are available in the open access image analysis package TINA



The TINA image analysis website

The TINA package is an open source image analysis software package supported by ISBE. It contains a considerable number of analysis tools for medical data including tools for:

  • Coregistration of brain images
  • Correction of image intensity heterogeneity due to MRI coil abnormalities
  • Automated assessment of cerebral atrophy from MRI
  • Automatic identification of Taliarach coordinates and Brodman's areas
  • Measurement of regional cortical thickness
  • Measurement of regional cerebral small vessel blood flow from dynamic susceptibility MRI
  • Measurement of contrast transfer coefficient, cerebral blood volume and extravascular extracellular space volume from dynamic T1 weighted images

 

My collaborations

Members of the Research Team:

  • Dr Neil Thacker, Senior lecturer in image analysis
  • Dr Geoff Parker, Research Fellow in MR physics
  • James O'Connor, reader in cancer imaging.
  • John C Waterton, Prof of imaging science.
  • Marie-Claude Asselin, senior lecturer in PETimaging.
  • Julian Matthews, senior lecturer in PETimaging
  • Rainer Heinz, senior lecturer in PETimaging
  • Ka-loh Li, research fellow in MR image analysis.
  • Xiaoping Zhu, honorary senior lecturer in imaging physics.
  • David Coope, honorary lecturer in neurosurgery.
  • Corinne Faivre-Finn, Prof of oncology
  • Federico Roncarolli, Prof of neuropathology
  • Joseph Naish, lecturer in magnetic resonance imaging,
  • Kay Williams, Prof of pharmacology.

Collaborators

  • Kevin Brindle, Prof of molecular imaging, University of Cambridge
  • Fiona Gilbert, Prof of radiology, University of Cambridge
  • Caroline Dive, Prof of experimental biology, University of Manchester
  • Gordon Jason, Prof of oncology, University of Manchester
  • Karl Herholz, Prof of neurology, University of Manchester.
  • Nandita De Souza, Prof of radiology Institute for Cancer research
  • M. Wintermark, Stanford University.
  • B. Wu, University of Beijing.
  • W. Zhang, University of Beijing.
  • J. Tu, University of Beijing.
  • G. Zhu, Third Military Medical University, Chongqing, China
  • Philippe Lambin, Maastricht University Medical Centre, Maastricht, the Netherlands

 

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 13 - Climate Action
  • SDG 14 - Life Below Water

External positions

Consultant Neuroradiologist, Salford Royal NHS Foundation Trust

Research Beacons, Institutes and Platforms

  • Digital Futures
  • Christabel Pankhurst Institute

Keywords

  • MRI, Imaging, Biomarkers, PET

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