Research output per year
Research output per year
Dr Aleksandra Galetin is a Professor of Translational Pharmacokinetics in the Division of Pharmacy & Optometry, School of Health Sciences, and Deputy Director of the Centre for Applied Pharmacokinetic Research (CAPKR, https://www.capkr.manchester.ac.uk/), University of Manchester. In 2004 she was appointed as a Pfizer Lecturer at the University of Manchester, following her position as a Postdoctoral Research Associate in the CAPKR. She is the recipient of the 2012 ISSX European New Investigator Award and 2015 AAPS Meritorious Manuscript Award for outstanding achievements in pharmaceutical sciences. She was a member of the ISSX Council (2017-2021) and in 2022, she has started her term in office as ISSX President-Elect; her role as ISSX President will begin in 2024 (https://www.issx.org/).
Prof. Galetin has long standing leadership positions on the expert panels such as International Transporter Consortium (ITC) and AAPS Drug Transport Focus Group Steering Committee (2014-2018). She co-edited a special issue in Clin Pharmacol Ther Nov 2018 dedicated to Advances in the role of drug transporters in drug development. Since 2013, Dr Galetin led/contributed to 10 ITC position papers, defining best practices for the application of endogenous biomarkers and PBPK modelling of transporter-mediated drug-drug interactions (DDI) among others topics. In 2016, she had a sabbatical in the US FDA Office of Clinical Pharmacology where she provided expert advice on PBPK modelling and simulation of drug exposure in specific populations and prediction of DDIs in new drug applications.
Prof. Galetin has published more than 120 research papers in highly cited peer reviewed journals (H index 49, >6,700 citations), received numerous invitations to present at international meetings and supervised/mentored over 40 PhD students and postdoctoral research associates.
Mechanistic in vitro characterisation of hepatic and renal transporters in 2D and 3D cellular systems and quantitative translation of such data using physiologically-based pharmacokinetic (PBPK) models
Endogenous biomarkers for hepatic and renal transporters/ DDIs
Extrapolation of in vitro data to predict in vivo pharmacokinetics
PBPK modelling of chronic kidney disease
In vitro and in silico assessment of lysosomal sequestration and implications on the intracellular drug concentration
Mechanistic evaluation of drug-drug interaction risk associated with therapeutic peptides
Optimisation of drug therapy in obesity based on consideration of host-microbiome interplay
Complete list of my published work can be found at:
https://scholar.google.com/citations?hl=en&user=AooQ7JQAAAAJ
Under-graduate teaching:
PHAR30100 The Medicine - Drug Development 2 (Module Lead)
CHEM30441 Advanced Drug Discovery
Postgraduate teaching:
MSc in Model-based Drug Development, University of Manchester
MSc for Independent Prescribers, University of Manchester - problem based learning on ADME and dosage regimen design
MRes in Experimental Cancer Medicine - drug disposition and pharmacokinetics lectures/workshops to support clinical trial and research portfolio of the programme
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Meeting Abstract › peer-review
Research output: Contribution to conference › Paper › peer-review
Galetin, Aleksandra (Recipient), 2012
Prize: Prize (including medals and awards)
Aleksandra Galetin (Co-Chair)
Activity: Participating in or organising event(s) › Participating in a conference, workshop, exhibition, performance, inquiry, course etc › Research
Malcolm Rowland (Participant), James Houston (Participant), Leon Aarons (Participant), Aleksandra Galetin (Participant) & Amin Rostami-Hodjegan (Participant)
Impact: Health impacts
Amin Rostami-Hochaghan (Participant), Leon Aarons (Participant), Aleksandra Galetin (Participant), Jill Barber (Participant), Kayode Ogungbenro (Participant) & Adam Darwich (Participant)
Impact: Technological impacts, Economic, Health and wellbeing, Policy