Personal profile
Biography
Dr Aleksandra Galetin is a Professor of Translational Pharmacokinetics in the Division of Pharmacy & Optometry, School of Health Sciences, and Deputy Director of the Centre for Applied Pharmacokinetic Research (CAPKR), at the University of Manchester. In 2004 she was appointed as a Pfizer Lecturer at the University of Manchester, following her position as a Postdoctoral Research Associate in the CAPKR. Dr Galetin is the recipient of the 2012 ISSX European New Investigator Award and 2015 AAPS Meritorious Manuscript Award for outstanding achievements in pharmaceutical sciences. She was on the ISSX Council (2017-2021) and rejoined the Council in 2022 as ISSX President Elect. She was President of ISSX in 2024-2025 (https://www.issx.org/) and is one of the initiators of the ISSX Africa Chapter.
Prof. Galetin has long standing leadership positions on the expert panels such as International Transporter Consortium (ITC, current co-chair) and AAPS Drug Transport Focus Group Steering Committee (2014-2018). She co-edited a special issue in Clin Pharmacol Ther Nov 2018 dedicated to Advances in the role of drug transporters in drug development. Since 2013, Dr Galetin led/contributed to 14 ITC position papers, defining best practices for the application of endogenous biomarkers and PBPK modelling of transporter-mediated drug-drug interactions (DDI) among others topics. In 2016, she had a sabbatical in the US FDA Office of Clinical Pharmacology where she provided expert advice on PBPK modelling and simulation of drug exposure in specific populations and prediction of DDIs in new drug applications.
Prof. Galetin has published more than 135 research papers in highly cited peer reviewed journals (H index 55, >8,330 citations). She has been listed in top 0.66% Stanford list of highly cited researchers in 2025. She has received numerous invitations to present at international meetings and has supervised/mentored over 45 PhD students and postdoctoral research associates.
Research interests
Mechanistic in vitro characterisation of hepatic and renal transporters in 2D and 3D cellular systems and quantitative translation of such data using physiologically-based pharmacokinetic (PBPK) models
Endogenous biomarkers for hepatic and renal transporters/ DDIs
Extrapolation of in vitro data to predict in vivo pharmacokinetics
PBPK modelling of chronic kidney disease
Mechanistic evaluation of drug-drug interaction risk associated with therapeutic peptides
Optimisation of drug therapy in obesity based on consideration of host-microbiome interplay
Complete list of my published work can be found at:
https://scholar.google.com/citations?hl=en&user=AooQ7JQAAAAJ
Teaching
Under-graduate teaching:
PHAR22002 - Simulation workshop lead
PHAR33001 - block 2 lead
CHEM30441 Advanced Drug Discovery
Postgraduate teaching:
MSc in Model-based Drug Development, University of Manchester
MRes in Experimental Cancer Medicine - drug disposition and pharmacokinetics lectures/workshops to support clinical trial and research portfolio of the programme
My collaborations
- Current PhD Students: D Nguyen, H Kangne, C Sychterz
- Current Postdoctoral Research Associates: N Izat, M-N Paludetto, I Vermeulen, S Rezaee, L Capinha
- Current visiting scientist: Y Ujihira, T Yoshikado
- Former PhD Students, Postdoctoral Research Associates and visiting scientists: J Henshall, H Burt, L Hinton, P Kilford, H Cubitt, E Guest, H Graham, I Templeton, Y Yabe, K Menochet, S Tate, K Gill, C Sall, O Hatley, Y Kamiyama, H Nishimuta, M Gertz, R Sullivan, F Assmus, T de Bruyn, T Matsuzaki, M Kageyama, A Margolskee, N Tsamandouras, J Badee, N Matsunaga, A Ufuk, T Matsuzaki, E Sherbetjian, S Barnett, L Francis, D Scotcher, T van der Made, J Lang, A Ahmad, H Takita, Y Takita, N Melillo, N Milani, R Norgaard, J Hogan, S Tan, Y Cleary
- Centre for Applied Pharmacokinetic Research
- Simcyp Population-based Pharmacokinetic Modelling and Simulation
- Prof. Brian Houston
- Prof. Leon Aarons
- Prof. Amin Rostami
- Prof. John Miners
Memberships of committees and professional bodies
- Deputy Director of the Centre for Applied Pharmacokinetic Research
- ISSX President
- Member of the ISSX Council, ISSX Scientific Affairs Commitee and Awards Commitee (https://issx.org)
- Expert panels such as International Transporter Consortium Steering Committee (present, https://www.itc-transporter.org/) and AAPS Drug Transport Focus Group (2014-2018)
- Member of AAPS, ISSX, ASPET and ASCPT professional bodies
- Editorial Board Member of Clinical Pharmacology and Therapeutics journal
- Editorial Board member of Drug Metabolism and Disposition journal
- Person Designated for the Human Tissue for the Division of Pharmacy
- Member of the DPO Teaching Governance Committee
Qualifications
- 2001 – PhD, School of Pharmacy and Pharmaceutical Sciences, University of Manchester
- 1998 – MSc in Clinical Pharmacokinetics, School of Pharmacy, University of Belgrade
- 1993 – MPharm, School of Pharmacy, University of Belgrade
Research Beacons, Institutes and Platforms
- Digital Futures
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 9 Industry, Innovation, and Infrastructure
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Addressing a Common Misconception of Simple Additive and Cumulative Drug Inhibition: Multiple Weak Inhibitors of Common Metabolic Pathway Do Not Pose a Strong Interaction Risk!
Scotcher, D., Ghosh, A., Galetin, A. & Rostami-Hodjegan, A., 1 Feb 2026, In: Journal of Clinical Pharmacology. 66, 2, e70154.Research output: Contribution to journal › Commentary/debate › peer-review
Open Access -
Overlooked aspects of scaling enzyme activity through abundance across tissues and individuals: Preliminary Insights from kcat measurements in matched liver and intestinal samples
Al-Majdoub, Z., Barber, J., Rostami-Hochaghan, A., Galetin, A. & Scotcher, D., 1 Apr 2026, In: Drug Metabolism and Disposition. 54, 4, 100229.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteomics-informed physiologically-based pharmacokinetic modelling for aldehyde oxidase substrates in colorectal cancer liver metastasis
Izat Stogias, N., Vasilogianni, A. M., Al-Majdoub, Z., Houston, J. B., Galetin, A., Rostami-Hodjegan, A., Barber, J. & Scotcher, D., 13 Apr 2026, (Accepted/In press) In: Molecular Pharmaceutics.Research output: Contribution to journal › Article › peer-review
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Assessing Drug-mediated Inhibition of Liver Transporter Function with MRI: A First-in-Human Study
Min, T., Tibiletti, M., Hockings, P. D., Galetin, A., Gunwhy, E., Shalom, E., Kenna, J. G., Melillo, N., Parker, G. J. M., Schuetz, G., Scotcher, D., Waterton, J. C., Rowe, I. & Sourbron, S., 1 Dec 2025, In: Radiology. 317, 3, p. e251899Research output: Contribution to journal › Article › peer-review
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Challenges and Opportunities for Incorporating Physiological Information into Pharmacokinetic Models of Intranasal Drug Delivery to the Brain: A Review of Current Status and Future Trajectories
Rezaee, S., Al-Majdoub, Z. M., Galetin, A., Rostami-Hodjegan, A. & Ogungbenro, K., 16 Jun 2025, In: Molecular Pharmaceutics.Research output: Contribution to journal › Article › peer-review
Open AccessFile54 Downloads (Pure)
Prizes
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ISSX European New Investigator Award
Galetin, A. (Recipient), 2012
Prize: Prize (including medals and awards)
Activities
- 1 Participating in a conference, workshop, exhibition, performance, inquiry, course etc
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12th International ISSX
Galetin, A. (Co-Chair)
28 Jul 2019 → 31 Jul 2019Activity: Participating in or organising event(s) › Participating in a conference, workshop, exhibition, performance, inquiry, course etc › Research
Impacts
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Drug Development: Influences on Regulatory Policies and Industrial Practices
Rowland, M. (Participant), Houston, J. (Participant), Aarons, L. (Participant), Galetin, A. (Participant) & Rostami-Hodjegan, A. (Participant)
Impact: Health impacts
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Modernising Drug Development Practices for Precision Dosing in Diverse Patient Populations
Rostami-Hochaghan, A. (Participant), Aarons, L. (Participant), Galetin, A. (Participant), Barber, J. (Participant), Ogungbenro, K. (Participant) & Darwich, A. (Participant)
Impact: Technological impacts, Economic, Health and wellbeing, Policy