Aleksandra Galetin

Aleksandra Galetin

Prof, Professor of Translational Pharmacokinetics

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Personal profile


Dr Aleksandra Galetin is a Professor of Translational Pharmacokinetics in the Division of Pharmacy & Optometry, School of Health Sciences, and Deputy Director of the Centre for Applied Pharmacokinetic Research (CAPKR,, University of Manchester. In 2004 she was appointed as a Pfizer Lecturer at the University of Manchester, following her position as a Postdoctoral Research Associate in the CAPKR. She is the recipient of the 2012 ISSX European New Investigator Award and 2015 AAPS Meritorious Manuscript Award for outstanding achievements in pharmaceutical sciences. She was a member of the ISSX Council (2017-2021) and in 2022, she has started her term in office as ISSX President-Elect; her role as ISSX President will begin in 2024 (

Prof. Galetin has long standing leadership positions on the expert panels such as International Transporter Consortium (ITC) and AAPS Drug Transport Focus Group Steering Committee (2014-2018). She co-edited a special issue in Clin Pharmacol Ther Nov 2018 dedicated to Advances in the role of drug transporters in drug development. Since 2013, Dr Galetin led/contributed to 10 ITC position papers, defining best practices for the application of endogenous biomarkers and PBPK modelling of transporter-mediated drug-drug interactions (DDI) among others topics.  In 2016, she had a sabbatical in the US FDA Office of Clinical Pharmacology where she provided expert advice on PBPK modelling and simulation of drug exposure in specific populations and prediction of DDIs in new drug applications.

Prof. Galetin has published more than 120 research papers in highly cited peer reviewed journals (H index 49, >6,700 citations), received numerous invitations to present at international meetings and supervised/mentored over 40 PhD students and postdoctoral research associates.

Research interests


Mechanistic in vitro characterisation of hepatic and renal transporters in 2D and 3D cellular systems and quantitative translation of such data using physiologically-based pharmacokinetic (PBPK) models


Endogenous biomarkers for hepatic and renal transporters/ DDIs


Extrapolation of in vitro data to predict in vivo pharmacokinetics


PBPK modelling of chronic kidney disease


In vitro and in silico assessment of lysosomal sequestration and implications on the intracellular drug concentration

Mechanistic evaluation of drug-drug interaction risk associated with therapeutic peptides

Optimisation of drug therapy in obesity based on consideration of host-microbiome interplay


Complete list of my published work can be found at:                   



Under-graduate teaching:

PHAR30100  The Medicine - Drug Development 2 (Module Lead)

CHEM30441 Advanced Drug Discovery


Postgraduate teaching:

MSc in Model-based Drug Development, University of Manchester

MSc for Independent Prescribers, University of Manchester - problem based learning on ADME and dosage regimen design

MRes in Experimental Cancer Medicine - drug disposition and pharmacokinetics lectures/workshops to support clinical trial and research portfolio of the programme

My collaborations

  • Current PhD Students:  Y Cleary, S Tan
  • Postdoctoral Research Associate: N Milani, R Norgaard, Z Al-Majdoub, J Hogan, N Izat
  • Former PhD Students and Postdoctoral Research Associates: J Henshall, H Burt, L Hinton, P Kilford, H Cubitt, E Guest, H Graham, I Templeton, Y Yabe, K Menochet, S Tate, K Gill, C Sall, O Hatley, Y Kamiyama, H Nishimuta, M Gertz, R Sullivan, F Assmus, T de Bruyn, M Kageyama, A Margolskee, N Tsamandouras, J Badee, N Matsunaga, A Ufuk, T Matsuzaki, E Sherbetjian, S Barnett, L Francis, D Scotcher, T van der Made, J Lang, A Ahmad, H Takita, Y Takita, N Melillo


Memberships of committees and professional bodies

  • Deputy Director of the Centre for Applied Pharmacokinetic Research
  • ISSX President Elect
  • Member of the ISSX Council, ISSX Scientific Affairs Commitee and Awards Commitee (
  • Appointed on the expert panels such as International Transporter Consortium Steering Committee ( and AAPS Drug Transport Focus Group (2014-2018)
  • Member of AAPS, ISSX, ASPET and ASCPT professional bodies
  • Editorial Board Member of Clinical Pharmacology and Therapeutics journal
  • Editorial Board member of Drug Metabolism and Disposition journal
  • Person Designated for the Human Tissue for the Division of Pharmacy
  • Member of the DPO Teaching Governance Committee


  • 2001 – PhD, School of Pharmacy and Pharmaceutical Sciences, University of Manchester
  • 1998 – MSc in Clinical Pharmacokinetics, School of Pharmacy, University of Belgrade
  • 1993 – MPharm, School of Pharmacy, University of Belgrade

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Beacons, Institutes and Platforms

  • Digital Futures


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Collaborations and top research areas from the last five years

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  • 12th International ISSX

    Aleksandra Galetin (Co-Chair)

    28 Jul 201931 Jul 2019

    Activity: Participating in or organising event(s)Participating in a conference, workshop, exhibition, performance, inquiry, course etcResearch