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Aleksandra Galetin

Aleksandra Galetin

Professor of Translational Pharmacokinetics , Prof

Personal profile

Biography

Dr Aleksandra Galetin is a Professor of Translational Pharmacokinetics in the Division of Pharmacy & Optometry, School of Health Sciences, and Deputy Director of the Centre for Applied Pharmacokinetic Research (CAPKR), at the University of Manchester. In 2004 she was appointed as a Pfizer Lecturer at the University of Manchester, following her position as a Postdoctoral Research Associate in the CAPKR. Dr Galetin was on the ISSX Council (2017-2021) and rejoined the Council in 2022 as ISSX President Elect. She was President of ISSX in 2024-2025 (https://www.issx.org/) and is one of the initiators of the ISSX Africa Program.

Prof. Galetin has long standing leadership positions on the expert panels such as International Transporter Consortium (ITC, current co-chair) and AAPS Drug Transport Focus Group Steering Committee (2014-2018).  Since 2013, Dr Galetin led/contributed to 14 ITC position papers, defining best practices for the application of endogenous biomarkers and PBPK modelling of transporter-mediated drug-drug interactions (DDI) among others topics.  In 2016, she had a sabbatical in the US FDA Office of Clinical Pharmacology where she provided expert advice on PBPK modelling and simulation of drug exposure in specific populations and prediction of DDIs in new drug applications.

Prof. Galetin has published more than 140 research papers in highly cited peer reviewed journals (H index 56, >8,530 citations). She has been listed in top 0.66% Stanford list of highly cited researchers in 2025. She has received numerous invitations to present at international meetings and has supervised/mentored over 45 PhD students and postdoctoral research associates.

Honours                              

ISSX 2026 European Scientific Achievement Award 

2015 AAPS Meritorious Manuscript Award for outstanding achievement in  pharmaceutical sciences 

2012 ISSX European New Investigator Award

 

Research interests

Mechanistic in vitro characterisation of hepatic and renal transporters in 2D and 3D cellular systems and quantitative translation of such data using physiologically-based pharmacokinetic (PBPK) models

Endogenous biomarkers for hepatic and renal transporters/ DDIs

Extrapolation of in vitro data to predict in vivo pharmacokinetics

PBPK modelling of chronic kidney disease

Mechanistic evaluation of drug-drug interaction risk associated with therapeutic peptides

Optimisation of drug therapy in obesity - virtual twin PBPK modelling using endogenous biomarker data

Complete list of my published work can be found at:                          

 https://scholar.google.com/citations?hl=en&user=AooQ7JQAAAAJ

Teaching

Under-graduate teaching:

PHAR22002  - Simulation workshop lead

PHAR33001 - block 2 lead

CHEM30441 Advanced Drug Discovery

 

Postgraduate teaching:

MSc in Model-based Drug Development, University of Manchester

MRes in Experimental Cancer Medicine - drug disposition and pharmacokinetics lectures/workshops to support clinical trial and research portfolio of the programme

My collaborations

  • Current PhD Students:   D Nguyen, H Kangne, C Sychterz
  • Current Postdoctoral Research Associates:  M-N Paludetto, I Vermeulen, L Capinha
  • Current visiting scientist: Y Ujihira, T Yoshikado
  • Former PhD Students, Postdoctoral Research Associates and visiting scientists: J Henshall, H Burt, L Hinton, P Kilford, H Cubitt, E Guest, H Graham, I Templeton, Y Yabe, K Menochet, S Tate, K Gill, C Sall, O Hatley, Y Kamiyama, H Nishimuta, M Gertz, R Sullivan, F Assmus, T de Bruyn, T Matsuzaki, M Kageyama, A Margolskee, N Tsamandouras, J Badee, N Matsunaga, A Ufuk, T Matsuzaki, E Sherbetjian, S Barnett, L Francis, D Scotcher, T van der Made, J Lang, A Ahmad, H Takita, Y Takita, N Melillo, N Milani, R Norgaard, J Hogan, S Tan, Y Cleary, N Izat, S Rezaee

 

Memberships of committees and professional bodies

  • Deputy Director of the Centre for Applied Pharmacokinetic Research
  • Co-chair of the International Transporter Consortium Steering Committee (https://www.itc-transporter.org/)
  • Chair of ISSX Nomination Commitee 
  • ISSX President (2024-2025) and chair of ISSX Council 
  • Past member of the ISSX Scientific Affairs Commitee and chair of the ISSX Awards Commitee (https://issx.org)
  • Member of AAPS Drug Transport Focus Group (2014-2018)
  • Member of ISSX, ASPET, AAPS and ASCPT professional bodies
  • Editorial Board Member of Clinical Pharmacology and Therapeutics journal
  • Editorial Board member of Drug Metabolism and Disposition journal
  • Person Designated for the Human Tissue for the Division of Pharmacy
  • Member of the DPO Teaching Governance Committee

Qualifications

  • 2001 – PhD, School of Pharmacy and Pharmaceutical Sciences, University of Manchester
  • 1998 – MSc in Clinical Pharmacokinetics, School of Pharmacy, University of Belgrade
  • 1993 – MPharm, School of Pharmacy, University of Belgrade

Research Highlights, Institutes and Platforms

  • Digital Futures

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being
  2. SDG 9 - Industry, Innovation, and Infrastructure
    SDG 9 Industry, Innovation, and Infrastructure

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Collaborations and top research areas from the last five years

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  • 12th International ISSX

    Galetin, A. (Co-Chair)

    28 Jul 201931 Jul 2019

    Activity: Participating in or organising event(s)Participating in a conference, workshop, exhibition, performance, inquiry, course etcResearch