Aleksandra Galetin

Search results

• 2015

  Comparison of respiratory drug accumulation and lysosomal sequestration in NR8383 and primary human al veolar macrophages

  Ufuk, A., Plumb, J., Houston, B. & Galetin, A., 2015, host publication. Vol. A11.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Cynomoglus monkey as a preclinical model for the investigation of hepatic uptake of OATP substrates

  Bruyn, T. D., Barton, H. A., Bi, Y.-A., Cantrill, C., Galetin, A., Houston, B., Lin, J. & Kosa, R., 2015, host publication. Vol. P11.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• In Silico Prediction of Hepatocellular Drug Binding

  Assmus, F., Houston, B. & Galetin, A., Jun 2015, host publication. Vol. A10.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• "Time dependent" inhibition of hepatic uptake transporters in hepatocytes and implications on the assessment of transporter-mediated drug-drug interactions

  Kageyama, M., Houston, B. & Galetin, A., 2015, host publication. Vol. P43.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
• 2012

  EVALUATION OF FDA AND EMA MODELS' CUT-OFF VALUES FOR CYP3A INHIBITION PREDICTION: A COLLABORATIVE EFFORT AMONG ACADEMIC, REGULATORY AGENCIES, AND INNOVATION AND QUALITY CONSORTIUM (IQC) PHARMACEUTICAL SCIENTISTS.

  Vieira, M. L., Kirby, B., Ragueneau-Majlessi, I., Chien, J., Fisher, V. & Galetin, A., 2012, host publication. Vol. 91 (Suppl. 1): S48.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
• 2011

  Methodology optimisation in intestinal microsome preparation: Implications for scaling approaches

  Hatley, O., Jones, C., Galetin, A., Rostami-Hochaghan, A. & Rostami-Hodjegan, A., 2011, host publication. Vol. 43 (Suppl 2):44.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
• 2010

  Application of different in vitro systems for prediction of in vivo induction drug-drug interactions

  Galetin, A. & Houston, J., 2010, host publication. Vol. 143.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Contribution of active uptake to the hepatic clearance of seven OATP substrates in rat and human plated hepatocytes

  Menochet, K., Kenworthy, K., Houston, J. & Galetin, A., Sept 2010, host publication. Vol. 487.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

• Development of a novel method for updating the predicted partition coefficient values generated by an existing in silico prediction method

  Graham, H., Yates, J., Galetin, A. & Aarons, L., Nov 2010, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

• Drug clearance in different in vitro systems as a preliminary indicator of hepatic uptake

  Houston, J., Rostami-Hochaghan, A. & Galetin, A., Sept 2010, host publication. Vol. 510.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Extrapolation of in vitro intestinal clearance: establishing validated subcellular fraction scaling factors

  Hatley, O., Jones, C., Galetin, A. & Rostami-Hochaghan, A., Sept 2010, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

• Physiologically-based pharmacokinetic modelling approach to assess the uptake transporter-mediated drug-drug interaction potential of cyclosporine.

  Galetin, A. & Houston, J., 2010, host publication. Vol. 149.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Physiologically-based pharmacokinetic modelling of hepatic transporter substrate rosuvastatin

  Tate, S., Jones, H., Houston, J. & Galetin, A., Sept 2010, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
• 2009

  . Physiologically-Based Pharmacokinetic Modelling of Hepatic Uptake of Pravastatin and Rosuvastatin

  Galetin, A., Houston, J., Tate, S. & Jones, H., 25 Nov 2009, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

• A progress curve approach for the assessment of time-dependent inhibition of CYP3A4

  Burt, H., Lager, C., Hyland, R., Houston, B. & Galetin, A., 17 May 2009, Drug Metab Rev. Vol. Rev 41 (Suppl 1).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

• Assessment of Algorithms for Predicting Drug-Drug Interactions via Inhibition Mechanisms.

  Rostami-Hochaghan, A., Guest, E., Rowland, Y. K., Rostami-Hodjegan, A., Tucker, G., Houston, J. & Galetin, A., 23 Sept 2009, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

• Assessment of the contribution of transporter-mediated active uptake to the overall hepatic uptake clearance for a range of drugs

  Yabe, Y., Galetin, A. & Houston, J., 2009, host publication. Vol. 41 (Suppl. 3): 39..

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Comparison of in vivo and in silico methods to predict tissue:plasma partition coefficients in rat

  Graham, H., Jones, O., Galetin, A. & Aarons, L., 25 Nov 2009, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

• Contribution of intestinal first-pass metabolism to drug-drug interactions of orally administered drugs

  Galetin, A., 2009, host publication. Vol. (Suppl. 3): 25.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Evaluation of the transporter-mediated hepatic uptake in fresh rat hepatocytes

  Yabe, Y., Galetin, A. & Houston, J., 2009, host publication. Drug Metab Rev, Vol. 41 (Suppl. 1).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Impact of saturation of CYP3A4 and P-glycoprotein in vivo on the prediction of intestinal availability

  Gertz, M., Harrison, A., Davis, J., Houston, J. & Galetin, A., 2009, host publication. Vol. 41 (Suppl. 3): 29..

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• QGut Model as a Predictive Tool for Intestinal Availability in Human: Impact of In Vitro Permeability and Clearance

  Gertz, M., Fenner, K., Harrison, A., Davis, J., Houston, J. & Galetin, A., 6 Feb 2009, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
• 2008

  Assessment of the QGut Model As Predictive Tool For Intestinal Availability in human: Impact of the In Vitro Permeability and Clearance.

  Galetin, A., Houston, J., Gertz, M., Fenner, K., Harrison, A. & Davis, J., 6 Jul 2008, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Comparison of hepatic and intestinal Glucuronidation

  Galetin, A. & Houston, J., May 2008, host publication. 10th European Regional ISSX Meeting, Vol. 37-38.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Comparison of Hepatic and Intestinal Glucuronidation

  Cubitt, H., Houston, J. & Galetin, A., 2008, host publication. Drug Metab Rev, Vol. 40 (Suppl. 1): 37..

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Comparison of the extent of sulphation and glucuronidation in the intestine and liver for a range of drugs

  Cubitt, H., Houston, J. & Galetin, A., 2008, host publication. Vol. 140.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Effect of Albumin on Prediction of Glucuronidation Clearance Using Alamethicin Activated Human Liver Microsomes.

  Galetin, A., Houston, J., Kilford, P., Stringer, R. & Sohal, B., Jul 2008, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Impact of Intestinal CYP3A on Prediction of Drug-Drug Interactions

  Galetin, A., Jul 2008, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Impact of permeability on in vitro predictions of intestinal availability in the QGut model

  Gertz, M., Fenner, K., Harrison, A., Davis, J., Houston, J. & Galetin, A., 2008, host publication. Drug Metab Rev, Vol. 40 (Suppl. 1): 92.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Ketoconazole based Drug-drug Interactions - an update.

  Davis, J., Galetin, A. & Jones, B., 2008, host publication. Clin Pharmacol Ther, Vol. 83 (Suppl. 1): 33.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Prediction of Glucuronidation (UGT) clearance using alamethicin activated human liver microsomes

  Kilford, P., Stringer, R., Sohal, B., Houston, J. & Galetin, A., May 2008, Drug Metabolism Reviews. Suppl. 1 ed. Vol. 40 . p. 51-52 2 p. 79

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Alamethicin 100%
  • Ketoprofen 9%
  • Gemfibrozil 9%

• Uptake of repaglinide in HEK293 cells expressing OATP1B1 and plated human hepatocytes

  Hinton, L., Thomas, J., Kenworthy, K., Somers, G., Manchee, G., Galetin, A. & Houston, J., 2008, host publication. Drug Metab Rev, Vol. 40 (Suppl. 1):.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
• 2007

  Determination of the fraction metabolised by phase II (UGT) enzymes using human cryopreserved hepatocytes and 1-aminobenzo-triazole (ABT)

  Kilford, P., Stringer, R., Sohal, B., Houston, J. & Galetin, A., 2007, host publication. Vol. 39(1).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Prediction of hepatic uptake transporter (OATP1B1) drug-drug interactions

  Hinton, L., Thomas, J., Kenworthy, K., Somers, G., Manchee, G., Galetin, A. & Houston, J., 2007, host publication. Vol. 39.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Prediction of intestinal first-pass from in vitro metabolism and transport data.

  Gertz, M., Harrison, A., Davis, J., Houston, J. & Galetin, A., 2007, host publication. Vol. 39 (1). 2 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
• 2006

  Comparison of Metabolism and Transporter Models for Predicting Gemfibrozil Drug-Drug Interactions.

  Gibbons, L., Galetin, A. & Houston, J., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Heteroactivation of carbamazepine metabolism by endogenous steroids in human liver microsomes and cryopreserved human hepatocytes.

  Galetin, A., Houston, J., Henshall, A. & Harrison, A., Sept 2006, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Inhibition of Repaglinide Metabolism by Gemfibrozil in Microsomes and Hepatocytes.

  Galetin, A., Houston, J. & Gibbons, L., Sept 2006, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Maximal FG ratio as a pragmatic indicator of the extent of intestinal CYP3A4 inhibition interactions.

  Galetin, A., Houston, J., Gibbons, L., Burt, H. & Obach, R., Sept 2006, host publication.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Maximal FG ratio as a pragmatic indicator of the magnitude of intestinal CYP3A4 inhibition

  Galetin, A., Gibbons, L., Burt, H., Obach, R. & Houston, J., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1): 44.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Multisite kinetic modelling of interactions between UDP-glucuronosyltransferase 2B7 (UGT2B7) substrates.

  Galetin, A., Uchaipichat, V., Mackenzie, P., Houston, J. & Miners, J., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1): 45.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Time-dependent inhibition of CYP3A4 by mibefradil in recombinant CYP3A4 and human liver microsomes and impact on in vivo predictions.

  Burt, H., Galetin, A. & Houston, J., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1):.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Variability in Heteroactivation of Carbamazepine Metabolism by Endogenous Steroids: Comparison of CYP3A4 and CYP3A5 Response.

  Henshall, J., Galetin, A., Harrison, A. & Houston, J., 2006, host publication. Drug Metab Rev, Vol. 38 (Suppl. 1):.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
• 2005

  Prediction of time-dependant drug-drug interactions - impact of parallel pathways, enzyme degradation and intestinal inhibition

  Galetin, A., Burt, H. & Houston, B., 2005, Drug Metabolism Reviews. Suppl 2 ed. Vol. 38.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
• 2002

  Multisite kinetic analysis of modified CYP3A4 activity: Interactions between midazolam, testosterone, nifedipine and felodipine.

  Galetin, A., Clarke, S. E., Bloomer, J. & Houston, B., 2002, Eur J Pharmac Sci. Vol. 17.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
• 2001

  Quinidine as a modifier of a modifier of several CYP3A4 substrates.

  Galetin, A., Clarke, S. E., Bloomer, J. & Houston, B., 2001, Drug Metabolism Reviews. Vol. 33, Suppl. 1.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution