Personal profile


Dr Horsley is a clinical academic at the University of Manchester and consultant at the Manchester Adult Cystic Fibrosis Centre. He is academic lead for the CF Centre where he leads a programme of basic science and clinical research as part of The University of Manchester NIHR Biomedical Research Centre in Respiratory Medicine. His main work focusses on novel technologies and clinical applications for lung clearance index (LCI), how this relates to clinical outcomes and imaging, and encompasses all age groups from infants to adults. He is medical director of the NIHR Manchester Clinical Research Facility at Wythenshawe Hospital, and leads a wide range of clinical trials in CF, including phase 1, both as principal and chief investigator. Dr Horsley has contributed to national policy on CF medications, to international guidelines on multiple breath washout, and is chief editor and author of the Oxford University Press Handbook on CF.


1991-1994  - Cambridge University, MA(Cantab) (1st)

1994-1997 - Edinburgh University. MBChB (Honours, Gold Medal)

2003            MRCP (Ed)

2003-2005 - Respiratory SpR training, Yorkshire Deanery

2005-2008 - PhD (Edinburgh University) "Non-invasive assessment of ventilation maldistribution in lung disease using multiple breath inert gas washouts"

2008-2010 - Respiratory SpR training, SW Scotland Deanery

2010-2011 - CF Trust Senior Training Fellow, Manchester Adult CF Centre

2011-2012 - Pickering fellow, Manchester University / Manchester Adult CF Centre

2013-2018 - NIHR Clinician Scientist Fellowship, University of Manchester

2013 -         Senior Lecturer, University of Manchester. Honorary Consultant, Wythenshawe Hospital


Research interests

Lung Clearance Index in the assessment of airways disease

Infant lung function

Lung imaging and physiology

Role of mucins in CF airway pathophysiology

Lung infections in CF


My collaborations

Local Collaborators:

Dr David Thornton, University of Manchester

Dr Clare Murray, University of Manchester

Prof David Singh, University of Manchester

Dr Pippa Watson, University of Manchester

Dr Mo Alaloul, University of Manchester


External Collaborators:

Prof  Jim Wild, University of Sheffield

Dr Daniel Weiner, Pittsburgh Childrens Hospital

Prof Daniel Peckham, Leeds Adult CF Centre

Prof Paul O'Brien, Elaros Ltd

Memberships of committees and professional bodies

European Respiratory Society

European Cystic Fibrosis Society

British Thoracic Society

Royal College of Physicians (Edinburgh)

Methodological knowledge

Clinical research skills: multiple breath washout tests and analysis, pulmonary function testing, sputum induction, endo-bronchial biopsy, brushing and lavage.

Clinical trials experience: study design, applying for ethical approval, patient recruitment, data collection and statistical analysis

Technical and laboratory skills: signal processing and data analysis for multiple breath washout tests, washout apparatus design and testing, sputum processing and analysis.



MA (Cantab) 1997 (1st class)

MBChB (Edinburgh) 1997 (Honours, and Ettles Gold Medal for most distinguished graduate)

MRCP (Edinburgh) 2002

PhD (Edinburgh) 2009

CCST Respiratory and General Internal Medicine, 2009

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Beacons, Institutes and Platforms

  • Lydia Becker Institute


  • Cystic Fibrosis
  • Lung physiology
  • Lung Clearance Index
  • Lung infection
  • Lung imaging
  • Clinical Trials


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