Alexander Mathioudakis


Personal profile


Alexander G. Mathioudakis is an NIHR Clinical Lecturer in Respiratory Medicine, at the University of Manchester and Manchester University NHS Foundation Trust. His research focuses on Airway Diseases phenotypes and personalised medicine, as well as clinical research methodology and evidence based medicine.

He graduated from the Medical School of National and Kapodistrian University of Athens (Greece, 2011) and started his clinical training in Respiratory and General Internal Medicine in Health Education North West. He undertook a Fellowship in Guidelines Methodology at Cochrane Iberoamerica and NICE (European Respiratory Society-ERS, 2016), followed by an Academic Clinical Fellowship in Respiratory Medicine at the University of Manchester (NIHR, 2016-2018) and a PhD Studentship by the NIHR Manchester Biomedical Reseach Centre (BRC, 2018-).

He has published over 90 peer review publications and has an h-index of 28 in Google Scholar. He has contributed to the development of the 2019 update of the British guideline on the management of asthma (SIGN/BTS, 2019) and of the ERS Guidelines on Sarcoidosis Management. He is also involved in the development of the ERS Guidelines on Pulmonary Alveolar Proteinosis (ongoing) and three methodological guidelines by GRADE on the conduct of systematic reviews (GRADE 17, 30 & Developing urgent response recommendations). He has received research funding for investigator initiated studies by Boehringer Ingelheim and the North West Lung Charity.

He is actively involved in the European Respiratory Society (ERS). He is currently the Secretary of ERS Group 5.1 (Airway Pharmacology & Treatment) and he has previously served in the Early Career Members Committee, as a representative of Assembly 5 (Airway Diseases: Asthma, COPD & Cough), a member of the Guidelines Working Group, and a member of the long-range planning committee of Assembly 5. Currently, he is a member of the British Thoracic Society Standards of Care Committee and the co-chair of an ERS/EAACI task force on asthma management and of an ERS task force on COPD exacerbations. He is also an Early Career Co-chair of the DisEntangling Chronic Obstructive pulmonary Disease Exacerbations: An international clinical trials NETwork (the DECODE-NET) and member of the Steering Committee of the Pediatric Asthma in Real Life (PeARL) think tank.

He periodically reviews grant proposals for National Institute for Health Research (NIHR-UK), Health Research Board (HBR-Ireland), and the European Respiratory Society (ERS).

He is an Editor of the Cochrane Airways (Cochrane Database of Systematic Reviews), associate editor of Breathe (ERS) and Folia Medica and a member of the editorial board of Frontiers in Allergy and Archives of Hellenic Medicine. He regularly peer reviews manuscripts for the BMJ, ERJ, AJRCCM, Chest, Allergy and other leading journals.

Research interests

- Clinical research on phenotyping and management of airway diseases, mainly COPD and COPD exacerbations.

- Precision medicine clinical trials.

- Clinical trials methodology.

- Systematic reviews, meta-analyses, clinical practice guidelines

- Core outcome sets.


MD - 2011

MRCP(UK) - 2015

PhD - 2022

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 13 - Climate Action

External positions

NIHR Academic Clinical Fellow in Respiratory Medicine, NHS Health Education North West

3 Aug 2016 → …

Areas of expertise

  • R Medicine (General)
  • COPD
  • Asthma
  • Bronchiectasis
  • Biomarkers
  • Precision Medicine
  • Evidence Based Medicine
  • Clinical Trials
  • Systematic reviews
  • Meta-analyses


  • COPD
  • asthma
  • bronchiectasis
  • clinical trials
  • meta-analyses
  • evidence based medicine


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