If you made any changes in Pure these will be visible here soon.

Personal profile


I am a BHF-funded PhD student working with Prof. Elizabeth Cartwright. I am interested in understanding how the Plasma Membrane Calcium ATPase 1 (PMCA1) affects cardiac remodelling during heart failure progression. My project merges computational and experimental methodologies to delve into the mechanisms of action of PMCA1 and its impact in cardiac health.

Employing cutting-edge machine learning techniques and bioinformatics pipelines, I analyse the transcriptome of both the entire heart and individual cardiac cells. Simultaneously, I validate key bioinformatic discoveries in vivo, in vitro, and ex vivo using a diverse array of techniques, including Langendorff perfusion, qPCR, western blotting, and a variety of histological staining methods (IF and IHC).

By seamlessly blending bioinformatics and molecular biology, I navigate the role of a "hybrid scientist." This approach allows me to unravel the complexities of heart failure and cardiac remodelling with a multidisciplinary and exhaustive perspective.

Prizes and awards

Highest Achieving Student in BSc Bioscience (2019) - University of Suffolk: Award for the highest achieving student in the BSc (Hons) Bioscience degree.

Top Project of the Year (2019) - The Royal Society of Biology: Award for the best undergraduate research project of the year.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Master of Research, Cardiovascular Science, The University of Manchester


Award Date: 30 Sept 2021

Master in Science, Human and Molecular Genetics, The University of Sheffield

30 Sept 201930 Jun 2020

Award Date: 30 Sept 2020

Bachelor of Science, Bioscience, University Of Suffolk

30 Sept 201630 Jun 2019

Award Date: 10 Oct 2019


Dive into the research topics where Alexandru Chelu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles