Amin Rostami-Hochaghan, PharmD, PhD, FCP, FAAPS, FJSSX

Prof

  • Professor of Systems Pharmacology, Pharmacy

Personal profile

Overview

Professor of Systems Pharmacology

Director of CAPKR

Biography

Amin is the Director of the Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester. In 2007, whilst working at the University of Sheffield, he became the first full Professor appointed with the title of "Systems Pharmacology". Professor Rostami has authored/co-authored over 300 highly cited articles (>23,000 citations, H-Factor >82) and in 2017 he was enlisted by ISI as one of the most highly cited researchers in the world (under the category of ‘Pharmacology & Toxicology’). Amin has been consistently at the top rank of the Highly Cited Researchers List by Stanford University (published by Elsevier) for pharmacology (<0.07 Top %). He was a founding editor of Pharmacometrics and System Pharmacology (CPT:PSP) and has been serving on the Editorial Boards of several other clinical pharmacology and drug metabolism journals over many years. Professor Rostami is renowned for his contribution to translational modelling (e.g. PBPK) and has been an invited speaker at over 200 international and national meetings, in addition to leading numerous workshops in the area of IVIVE- PBPK linked models.

Professor Rostami has an active program of training PhD students involving proteomics, PBPK, clinical PKPD and precision dosing.  Many graduates from his team hold positions in the pharmaceutical industry or academia.

As a co-founder of Simcyp Limited (a University of Sheffield spin-off acquired by Certara Inc.) he is part-time secondee at Certara. As its Chief Scientific Officer he ensures that the latest scientific advances in the field of biosimulation are incorporated into all of the drug development efforts by various pharmaceutical companies. Certara is the largest company focused on Modellling and Simulation as well as Regulatory Strategy in the space of pharmaceutical industry.

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Research interests

Research Interests

  • Applications of "systems biology" approach to prediction of drug absorption, distribution and elimination
  • Extrapolation of in vitro data to predict in vivo pharmacokinetics and
    Pharmacodynamics
  • Applications of PKPD in drug development and therapeutics, particularly in special populations and with a view to "Precision Dosing"
  • Applications of LCMS proteomics in clinical pharmacology


Activities and Distinctions

  • Author/co-author of over 230 peer-reviewed full articles; overall citations received (CR) >11,000 by January 2019; H factor of 55
  • Invited speaker in over 180 national and international meetings in the area of modelling in clinical pharmacology, drug metabolism, biopharmaceutics and systems pharmacology
  • Recipient of the EUFEPS (European Federation of Pharmaceutical Sciences) 2004 award for "New Sage Medicines Faster" initiative (jointly with Professor Tucker)
  • OSCAR (outstanding scientific contribution to animal replacement) award by Hadwen Trust for Humane research in 2009 and Queens Award for Enterprise.

My collaborations

  • Dr Jill Barber (Reader / National Teaching Fellow)

Centre for Applied Pharmacokinetic Research

  • Leon Aarons (Professor of Pharmacometrics)
  • Brian Houston (Professor of Drug Metabolism and Pharmacokinetics)
  • Aleksandra Galetin (Reader of Drug Metabolism and Pharmacokinetics)
  • Kayode Ogungbenro (Lecturer)
  • Adam Darwich (Lecturer)
  • David Hallifax (Research Fellow)

Postdoctoral Research Associates

  • Brahim Achour
  • Zubida al-Majdoub
  • Daniel Scotcher

PhD Students

  • Hajar Al-Feteisi

  • Martyn Howard

  • Jokha Al-Qassabi

  • Areti Vasilogianni

  • Sarah Alrubia

  • Eman El-Khateeb

 

Memberships of committees and professional bodies

 

  • Co-Chair of ISoP International Advisory Board
  • Member of Host Madsen Award Committee of FIP
  • Member of the ISSX Finance Committee

Editorial Boards:

  • Acta Pharmaceutica Sciencia since 2007 (International Editorial Board)
  • Biopharm Drug Disposition (European Editor 2009 - present)
  • Clinical Pharmacology & Therapeutics: Pharmacometrics & Systems Pharmacology (Associate Editor 2012-2016)
  • Current Drug Metabolism (Co-Editor since 2015, Associate Editor for Europe 2006-2015)
  • Drug Metabolism & Pharmacokinetics (2006-present)
  • Drug Metabolism Letters (2006-2014)
  • Frontiers in Drug Metabolism and Transport (2010-present)
  • Frontiers in Toxicity Prediction (2010-present)
  • Xenobiotica (2005-2015)

Learned Societies:

Fellow of:

  • American College of Clinical Pharmacology (ACCP)
  • Clinical Section of Br Pharmacological Society (BPS)
  • Japanese Society for the Study of Xenobiotics (JSSX)
  • American Association of Pharmaceutical Sciences (ACCP)

Member of:

  • American Association of Pharmaceutical Sciences (AAPS)
  • American College of Clinical Pharmacology (ACCP)
  • American Society of Clinical Pharmacology and Therapeutics (ASCPT)
  • International Society of Pharmacometrics (ISoP) International Society for the Study of Xenobiotics (ISSX)
  • American Society for Pharmacology and Experimental Therapeutics (ASPET)

Methodological knowledge


 

Qualifications

  • 1987 - PharmD (Tabriz)

  • 1996 - PhD (Sheffield)

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

External positions

Chief Scientific Officer, Certara USA Inc

Research Beacons, Institutes and Platforms

  • Digital Futures
  • Institute for Data Science and AI

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