Professor of Systems Pharmacology

Director of Centre for Applied Pharmacokinetic Research (CAPKR)

Amin is the Director of the Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester.

The Institute of Scientific Information (ISI, Clativate) listed Amin as one of the world’s most highly cited researchers (under ‘Pharmacology & Toxicology’) in 2017. Amin is at 0.07% top rank of the Highly Cited Researchers List by Stanford University (published by Elsevier) for Pharmacology (2024). He has published over 330 peer reviewed influential scientific articles (>26,500 citations, h-index = 88, Google Scholar) covering various aspects of pharmaceutics, clinical/translational/systems pharmacology.

As the Director of CAPKR since 2017, Amin collaborates with many pharmaceutical companies with a view to transfer latest scientific knowledge into model-informed drug development. Amin was co-founder of two spin-off companies from the University of Sheffield (Simcyp Limited [now part of Certara Inc]) and Diurnal Limited [now part of Neurocrine Bioscience]).

As a leader in the field of physiologically-based pharmacokinetics (PBPK) and Quantitative Systems Pharmacology (QSP), he is internationally recognized and he was one of the founding editors of Pharmacometrics and System Pharmacology in addition to serving on the Editorial Boards of many other pharmacology journals.

In his external appointment, as the Senior Vice President of Research & Development (SVP) and Chief Scientific Officer at Certara since 2014, he facilitates the integration of the latest translational modelling to bio-simulation platforms offered by Certara to its clients, with the aim of accelerating the drug development and regulatory approval.

Professor Rostami has an active program of training PhD students involving proteomics, PBPK, clinical PKPD and precision dosing.  Many graduates from his team hold positions in the pharmaceutical industry or academia.

Research Interests

• Applications of "systems biology" approach to prediction of drug absorption, distribution and elimination
• Extrapolation of in vitro data to predict in vivo pharmacokinetics and
  Pharmacodynamics
• Applications of PKPD in drug development and therapeutics, particularly in special populations and with a view to "Precision Dosing"
• Applications of LCMS proteomics in clinical pharmacology

Activities and Distinctions

• Author/co-author of over 330 peer-reviewed full articles; overall citations received (CR) >26,000 by Octover 2025; H factor of 88
• Invited speaker in over 250 national and international meetings in the area of modelling in clinical pharmacology, drug metabolism, biopharmaceutics and systems pharmacology
• Receipent of Lewis Sheiner Lecturer Award from ISoP (International Society of Pharmacometrics) in 2025.
• Receipient of European Scientific Research Achievement Award from ISSX (International Society of Studying Xenobiotics) 2023.
• Joint recipient of ISoP (International Society of Pharmacometrics) award for Research Innovation (2022)
• Recipient of the EUFEPS (European Federation of Pharmaceutical Sciences) 2004 award for "New Sage Medicines Faster" initiative (jointly with Professor Tucker)
• OSCAR (outstanding scientific contribution to animal replacement) award by Hadwen Trust for Humane research in 2009 and Queens Award for Enterprise.
• Fellowship Awards by several scientific societies for being a distinguished contributor and an acknowledged leader in the fields of Clinical Pharmacology (FCP - American College of Clinical Pharmacology; FBPS – British Pharmacological Society), Pharmaceutical Science (FAAPS – American Association of Pharmaceutical Sciences), and Study of   Xenobiotics (FJSSX – Japanese Society of Study of Xenobiotics),

Centre for Applied Pharmacokinetic Research

• Dr Jill Barber (Reader / National Teaching Fellow)
• Leon Aarons (Professor of Pharmacometrics)
• Brian Houston (Professor of Drug Metabolism and Pharmacokinetics)
• Aleksandra Galetin (Reader of Drug Metabolism and Pharmacokinetics)
• Kayode Ogungbenro (Senior Lecturer)
• Dr Daniel Scotcher (Lecturer)
• Dr Zubida Al-Majdoub (Research Fellow)

• Member of the ISSX Council

• 1987 - PharmD (Tabriz)

• 1996 - PhD (Sheffield)