Personal profile

Overview

Historically, the two major ‘systems’ of the body were divided into nervous and immune. The former containing the electrical wiring governing our senses and our mind, the latter consisting of mobile defence cells ready to fight infection, disease and injury. It is only now we are beginning to understand that our nerves and immune cells are so intertwined that their roles are dependent on one another. Microglia, the brain’s resident immune cells are now known to be involved in a host of brain functions, including development, neuronal function and protection from, or propagation of, disease. Recent evidence even shows that the higher functions of mammalian brains, those that manage emotions such as anxiety, and social behaviour and memory, can be also affected by mobile immune cells that have travelled to the edges of the brain. In certain circumstances, the brain may become inflamed, due to an injury or disease. This can even happen in ‘mild’ injuries such as a bang to the head, resulting in concussion.

 

My lab is interested in how immune cells resident in, or recruited to, the brain mediate recovery from injury and how this affects normal brain functions controlling anxiety, cognition and mental health.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research Beacons, Institutes and Platforms

  • Lydia Becker Institute

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Collaborations and top research areas from the last five years

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  • The meningeal immune landscape in mucopolysaccharidosis type IIIA

    Parker, H., Donald, A. & Greenhalgh, A., Feb 2024, In: Molecular genetics and metabolism.

    Research output: Contribution to journalArticlepeer-review

  • Microglia states and nomenclature: A field at its crossroads

    Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M. E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., Bennett, F., Bessis, A., Biber, K., Bilbo, S., Blurton-Jones, M., Boddeke, E., Brites, D., Brône, B., Brown, G. C., Butovsky, O., & 76 othersCarson, M. J., Castellano, B., Colonna, M., Cowley, S. A., Cunningham, C., Davalos, D., De Jager, P. L., de Strooper, B., Denes, A., Eggen, B. J. L., Eyo, U., Galea, E., Garel, S., Ginhoux, F., Glass, C. K., Gokce, O., Gomez-Nicola, D., González, B., Gordon, S., Graeber, M. B., Greenhalgh, A. D., Gressens, P., Greter, M., Gutmann, D. H., Haass, C., Heneka, M. T., Heppner, F. L., Hong, S., Hume, D. A., Jung, S., Kettenmann, H., Kipnis, J., Koyama, R., Lemke, G., Lynch, M., Majewska, A., Malcangio, M., Malm, T., Mancuso, R., Masuda, T., Matteoli, M., McColl, B. W., Miron, V. E., Molofsky, A. V., Monje, M., Mracsko, E., Nadjar, A., Neher, J. J., Neniskyte, U., Neumann, H., Noda, M., Peng, B., Peri, F., Perry, V. H., Popovich, P. G., Pridans, C., Priller, J., Prinz, M., Ragozzino, D., Ransohoff, R. M., Salter, M. W., Schaefer, A., Schafer, D. P., Schwartz, M., Simons, M., Smith, C. J., Streit, W. J., Tay, T. L., Tsai, L. H., Verkhratsky, A., von Bernhardi, R., Wake, H., Wittamer, V., Wolf, S. A., Wu, L. J. & Wyss-Coray, T., 2 Nov 2022, In: Neuron. 110, 21, p. 3458-3483 26 p.

    Research output: Contribution to journalReview articlepeer-review

    Open Access
  • Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia

    Trigiani, L. J., Lacalle‐aurioles, M., Bourourou, M., Li, L., Greenhalgh, A. D., Zarruk, J. G., David, S., Fehlings, M. G. & Hamel, E., 10 Mar 2020, (E-pub ahead of print) In: GLIA. 68, 9, p. 1925-1940

    Research output: Contribution to journalArticlepeer-review

  • Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

    Madore, C., Leyrolle, Q., Morel, L., Rossitto, M., Greenhalgh, A. D., Delpech, J. C., Martinat, M., Bosch-bouju, C., Bourel, J., Rani, B., Lacabanne, C., Thomazeau, A., Hopperton, K. E., Beccari, S., Sere, A., Aubert, A., De Smedt-peyrusse, V., Lecours, C., Bisht, K., Fourgeaud, L., & 13 othersGregoire, S., Bretillon, L., Acar, N., Grant, N. J., Badaut, J., Gressens, P., Sierra, A., Butovsky, O., Tremblay, M. E., Bazinet, R. P., Joffre, C., Nadjar, A. & Layé, S., 30 Nov 2020, In: Nature Communications. 11, 1, 6133.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Immune cell regulation of glia during CNS injury and disease

    Greenhalgh, A. D., David, S. & Bennett, F. C., 10 Feb 2020, (E-pub ahead of print) In: Nature Reviews. Neuroscience. 21, 3, p. 139-152

    Research output: Contribution to journalArticlepeer-review