Research output per year
Research output per year
Personal profile
Overview
I am a computational chemist working in the Division of Pharmacy and Optometry at the University of Manchester. My group investigates computational approaches applied to drug discovery and to understanding reactivity. For more information, please take a look at our group webpages (https://www.leachresearchgroup.net/)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Beacons, Institutes and Platforms
- Digital Futures
- Christabel Pankhurst Institute
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Collaborations and top research areas from the last five years
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Dynamic self-assembled meso-structures formed across a wide concentration range in aqueous solutions of propranolol hydrochloride
Yan, Y., Shen, Y., Mahmoudi, N., Li, P., Tellam, J., Campbell, R. A., Barlow, D. J., Edkins, K., Leach, A. G. & Lawrence, M. J., 1 Apr 2025, In: Journal of Colloid and Interface Science. 683, Part 1, p. 1135-1149Research output: Contribution to journal › Article › peer-review
Open Access -
The Boroxine–Boronic Acid Equilibrium
Li, C., Sotorrios, L., Boaler, P. J., Olikauskas, V., Amico, M., García-Domínguez, A., Leach, A. G. & Lloyd-Jones, G. C., 2025, In: Journal of the American Chemical Society.Research output: Contribution to journal › Article › peer-review
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Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome.
Green, J., El-Sharkawy, L., Roth, S., Zhu, J., Cao, J., Leach, A., Liesz, A., Freeman, S. & Brough, D., 19 May 2024, In: iScience. 26, 5, 106758.Research output: Contribution to journal › Article › peer-review
Open Access -
Photoswitchable Azobispyrazole Crystals Achieving Near-Quantitative Crystalline-State Bidirectional E ⇆ Z Conversions
He, Y., Dang, T., Leach, A. G., Zhang, Z. Y. & Li, T., 23 Oct 2024, In: Journal of the American Chemical Society. 146, 42, p. 29237-29244 8 p.Research output: Contribution to journal › Article › peer-review
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Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium
Seoane, P. I., Beswick, J. A., Leach, A. G., Swanton, T., Morris, L. V., Couper, K., Lowe, M., Freeman, S. & Brough, D., 22 Dec 2023, In: Cell death discovery. 9, 1, 469.Research output: Contribution to journal › Article › peer-review
Open Access