Andrew Leach

Search results

• 2017

  Matched Molecular Pair Analysis

  Leach, A. G., Lukac, I., Zarnecka, J. M., Dossetter, A. G. & Griffen, E. J., 3 Jun 2017, Comprehensive Medicinal Chemistry III. Elsevier BV, Vol. 3. p. 221-252 32 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • Analytical Method 100%
• 2015

  Challenges in the Medicinal Chemical Optimization of Binding Kinetics

  Waring, M. J., Leach, A. G. & Miller, D. C., 2 Jun 2015, Thermodynamics and Kinetics of Drug Binding. John Wiley & Sons Ltd, p. 191-210 20 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • Binding Kinetics 100%
  • Comprehension 50%
  • Volume 50%
  • Molecular Interaction 50%
  • Aptitude 50%

• Tactics to avoid inhibition of cytochrome P450s

  Leach, A. G., 2015, Tactics in contemporary drug design. Meanwell, N. A. (ed.). Heidelberg, New York, Dordrecht, London: Springer Nature, Vol. 9. p. 107-158 52 p. (Topics in Medicinal Chemistry Series).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • Cytochrome 100%
  • Comprehension 25%
  • Solution and Solubility 25%
  • Data Base 25%
  • Reduction (Chemistry) 25%
• 2014

  Cytochrome P450 Substrate Recognition and Binding

  Leach, A. G. & Kidley, N. J., 25 Aug 2014, Drug Metabolism Prediction. John Wiley & Sons Ltd, p. 103-132 30 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
• 2005

  Theoretical Studies of Antibody Catalysis

  Tantillo, D. J., Leach, A. G., Zhang, X. & Houk, K. N., 13 May 2005, Catalytic Antibodies. John Wiley & Sons Ltd, p. 72-117 46 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review