Research output per year
Research output per year
- 1 - 50 out of 96 results
Search results
-
2025
Dynamic self-assembled meso-structures formed across a wide concentration range in aqueous solutions of propranolol hydrochloride
Yan, Y., Shen, Y., Mahmoudi, N., Li, P., Tellam, J., Campbell, R. A., Barlow, D. J., Edkins, K., Leach, A. G. & Lawrence, M. J., 1 Apr 2025, In: Journal of Colloid and Interface Science. 683, Part 1, p. 1135-1149Research output: Contribution to journal › Article › peer-review
Open Access -
2024
Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome.
Green, J., El-Sharkawy, L., Roth, S., Zhu, J., Cao, J., Leach, A., Liesz, A., Freeman, S. & Brough, D., 19 May 2024, In: iScience. 26, 5, 106758.Research output: Contribution to journal › Article › peer-review
Open Access -
Photoswitchable Azobispyrazole Crystals Achieving Near-Quantitative Crystalline-State Bidirectional E ⇆ Z Conversions
He, Y., Dang, T., Leach, A. G., Zhang, Z. Y. & Li, T., 23 Oct 2024, In: Journal of the American Chemical Society. 146, 42, p. 29237-29244 8 p.Research output: Contribution to journal › Article › peer-review
-
2023
Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium
Seoane, P. I., Beswick, J. A., Leach, A. G., Swanton, T., Morris, L. V., Couper, K., Lowe, M., Freeman, S. & Brough, D., 22 Dec 2023, In: Cell death discovery. 9, 1, 469.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
A Lewis Base Nucleofugality Parameter, NBF, and Its Application in an Analysis of MIDA-Boronate Hydrolysis Kinetics
Taylor, N. P., Gonzalez, J. A., Nichol, G. S., García-Domínguez, A., Leach, A. G. & Lloyd-Jones, G. C., 7 Jan 2022, In: The Journal of organic chemistry. p. 721–729Research output: Contribution to journal › Article › peer-review
-
Asymmetric Synthesis of Heterocyclic Chloroamines and Aziridines by Enantioselective Protonation of Catalytically Generated Enamines**
McLean, L. A., Ashford, M. W., Fyfe, J. W. B., Slawin, A. M. Z., Leach, A. G. & Watson, A. J. B., 16 Mar 2022, In: Chemistry – A European Journal. 28, 16, e202200060.Research output: Contribution to journal › Article › peer-review
Open Access -
Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria
Gurvic, D., Leach, A. G. & Zachariae, U., 28 Apr 2022, In: Journal of Medicinal Chemistry. 65, 8, p. 6088-6099 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Enantiomer stability of atropisomeric 1,5-disubstituted 1,2,3-triazoles
Meloni, F., Brittain, W. D. G., Male, L., Duff, C. S. L., Buckley, B. R., Leach, A. G. & Fossey, J. S., Mar 2022, In: Tetrahedron Chem.Research output: Contribution to journal › Article › peer-review
-
In Situ Studies of Arylboronic Acids/Esters and R3SiCF3 Reagents: Kinetics, Speciation, and Dysfunction at the Carbanion–Ate Interface
García-Domínguez, A., Leach, A. G. & Lloyd-Jones, G. C., 3 May 2022, In: Accounts of Chemical Research. 55, 9, p. 1324-1336 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity
Cundy, N. J., Hare, R. K., Tang, T., Leach, A. G., Jowitt, T. A., Qureshi, O., Gordon, J., Barnes, N. M., Brady, C. A., Raven, E. L., Grainger, R. S. & Butterworth, S., 13 Sept 2021, In: RSC Chemical Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Heavy-Atom Kinetic Isotope Effects: Primary Interest or Zero Point?
Dale, H. J. A., Leach, A. G. & Lloyd-Jones, G. C., 22 Dec 2021, In: Journal of the American Chemical Society. 143, 50, p. 21079-21099 21 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mapping Ligand-Shape Space for Protein–Ligand Systems: Distinguishing Key-in-Lock and Hand-in-Glove Proteins
Zarnecka, J., Lukac, I., Messham, S. J., Hussin, A., Coppola, F., Enoch, S. J., Dossetter, A. G., Griffen, E. J. & Leach, A. G., 23 Mar 2021, In: Journal of Chemical Information and Modeling. 61, 4, p. 1859–1874Research output: Contribution to journal › Article › peer-review
Open AccessFile186 Downloads (Pure) -
Microwave-assisted synthesis of 4-oxo-2-butenoic acids by aldol-condensation of glyoxylic acid
Uguen, M., Gai, C., Sprenger, L. J., Liu, H., Leach, A. G. & Waring, M. J., 5 Oct 2021, In: RSC Advances. 11, p. 30229-30236Research output: Contribution to journal › Article › peer-review
Open Access -
Physiological and Pathological Factors Affecting Drug Delivery to the Brain by Nanoparticles
Islam, Y., Leach, A. G., Smith, J., Pluchino, S., Coxon, C. R., Sivakumaran, M., Downing, J., Fatokun, A. A., Teixidò, M. & Ehtezazi, T., 15 Mar 2021, In: Advanced Science.Research output: Contribution to journal › Article › peer-review
Open Access -
Protodeboronation of (Hetero)Arylboronic Esters: Direct versus Prehydrolytic Pathways and Self-/Auto-Catalysis
Hayes, H. L. D., Wei, R., Assante, M., Geogheghan, K. J., Jin, N., Tomasi, S., Noonan, G., Leach, A. G. & Lloyd-Jones, G. C., 15 Sept 2021, In: Journal of the American Chemical Society. 143, 36, p. 14814–14826Research output: Contribution to journal › Article › peer-review
Open Access -
Trialkylammonium salt degradation: implications for methylation and cross-coupling
Washington, J. B., Assante, M., Yan, C., McKinney, D., Juba, V., Leach, A. G., Baillie, S. E. & Reid, M., 13 Apr 2021, In: Chemical Science. 12, p. 6949-6963Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Catalytic enantioselective synthesis of heterocyclic vicinal fluoroamines using asymmetric protonation: A method development and mechanistic study
Watson, A. J. B., Ashford, M. W., Xu, C., Molloy, J. J., Carpenter-Warren, C., Slawin, A. M. Z. & Leach, A. G., 15 Jun 2020, In: Chemistry: A European Journal .Research output: Contribution to journal › Article › peer-review
Open Access -
Chemists: AI Is Here; Unite To Get the Benefits
Griffen, E. J., Dossetter, A. G. & Leach, A. G., 2020, In: Journal of Medicinal Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile845 Downloads (Pure) -
Development of Brain Targeting Peptide Based MMP-9 Inhibiting Nanoparticles for the Treatment of Brain Diseases with Elevated MMP-9 Activity
Islam, Y., Aneesa, K., Pluchino, S., Sivakumaran, M., Teixidò, M., Leach, A., Fatokun, A. A., Downing, J., Coxon, C. & Ehtezazi, T., 2020, In: Journal of Pharmaceutical Sciences.Research output: Contribution to journal › Article › peer-review
Open AccessFile100 Downloads (Pure) -
Difluorocarbene Generation from TMSCF3: Kinetics and Mechanism of NaI-Mediated and Si-Induced Anionic Chain Reactions
García-Domínguez, A., West, T. H., Primozic, J. J., Grant, K. M., Johnston, C. P., Cumming, G. G., Leach, A. G. & Lloyd-Jones, G. C., 13 Aug 2020, In: Journal of the American Chemical Society. 142, 34, p. 14649-14663 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile90 Downloads (Pure) -
Fragment-oriented synthesis: β-elaboration of cyclic amine fragments using enecarbamates as platform intermediates
Trindade, A. F., Faulkner, E. L., Leach, A. G., Nelson, A. & Marsden, S. P., 6 Jul 2020, In: Chemical communications (Cambridge, England).Research output: Contribution to journal › Article › peer-review
Open Access -
Racemisation in Chemistry and Biology
Ballard, A., Narduolo, S., Ahmed, H. O., Keymer, N. I., Asaad, N., Cosgrove, D. A., Buurma, N. J. & Leach, A. G., 23 Mar 2020, In: Chemistry – A European Journal.Research output: Contribution to journal › Article › peer-review
Open AccessFile3045 Downloads (Pure) -
2019
Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia
Li, X., Payne, D. T., Ampolu, B., Bland, N., Brown, J. T., Dutton, M. J., Fitton, C. A., Gulliver, A., Hale, L., Hamza, D., Jones, G., Lane, R., Leach, A. G., Male, L., Merisor, E. G., Morton, M. J., Quy, A. S., Roberts, R., Scarll, R. & Schulz-Utermoehl, T. & 4 others, , 1 Aug 2019, In: MedChemComm. 10, 8, p. 1379-1390Research output: Contribution to journal › Article › peer-review
Open Access -
Enhancing the kinetics of hydrazone exchange processes: an experimental and computational study
Higgs, P. L., Ruiz-Sanchez, A. J., Dalmina, M., Horrocks, B. R., Leach, A. G. & Fulton, D. A., 28 Mar 2019, In: Organic & biomolecular chemistry. 17, 12, p. 3218-3224Research output: Contribution to journal › Article › peer-review
Open Access -
Kinetics and Mechanism of the Arase-Hoshi R2BH-Catalyzed Alkyne Hydroboration: Alkenylboronate Generation via B-H/C-B Metathesis
Nieto-Sepulveda, E., Bage, A. D., Evans, L. A., Hunt, T. A., Leach, A. G., Thomas, S. P. & Lloyd-Jones, G. C., 20 Nov 2019, In: Journal of the American Chemical Society. 141, 46, p. 18600-18611 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile160 Downloads (Pure) -
Predicting protein-ligand binding affinity and correcting crystal structures with quantum mechanical calculations: lactate dehydrogenase A
Lukac, I., Abdelhakim, H., Ward, R. A., St-Gallay, S. A., Madden, J. C. & Leach, A. G., 21 Feb 2019, In: Chemical Science. 10, 7, p. 2218-2227Research output: Contribution to journal › Article › peer-review
Open Access -
Tuning the Binding Affinity and Selectivity of Perfluoroaryl-Stapled Peptides by Cysteine-Editing
Verhoork, S. J. M., Jennings, C. E., Rozatian, N., Reeks, J., Meng, J., Corlett, E. K., Bunglawala, F., Noble, M. E. M., Leach, A. G. & Coxon, C. R., 2 Jan 2019, In: Chemistry-A European Journal. 25, 1, p. 177-182Research output: Contribution to journal › Article › peer-review
Open Access -
2018
An investigation into drug partitioning behaviour in simulated pulmonary surfactant monolayers with associated molecular modelling
Davies, M. J., Leach, A. G. & Riley, F., Mar 2018, In: Surface and Interface Analysis. 50, 3, p. 369-377Research output: Contribution to journal › Article › peer-review
-
Anion-Initiated Trifluoromethylation by TMSCF3: Deconvolution of the Siliconate-Carbanion Dichotomy by Stopped-Flow NMR/IR
Johnston, C. P., West, T. H., Dooley, R. E., Reid, M., Jones, A. B., King, E. J., Leach, A. G. & Lloyd-Jones, G. C., 5 Sept 2018, In: Journal of the American Chemical Society. 140, 35, p. 11112-11124Research output: Contribution to journal › Article › peer-review
Open Access -
Catalytic Enantioselective Synthesis of alpha-Chiral Azaheteroaryl Ethylamines by Asymmetric Protonation
Xu, C., Muir, C. W., Leach, A. G., Kennedy, A. R. & Watson, A. J. B., 27 Aug 2018, In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 57, 35, p. 11374-11377Research output: Contribution to journal › Article › peer-review
-
Learning Medicinal Chemistry Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Rules from Cross-Company Matched Molecular Pairs Analysis (MMPA)
Kramer, C., Ting, A., Zheng, H., Hert, J., Schindler, T., Stahl, M., Robb, G., Crawford, J. J., Blaney, J., Montague, S., Leach, A. G., Dossetter, A. G. & Griffen, E. J., 26 Apr 2018, In: Journal of Medicinal Chemistry. 61, 8, p. 3277-3292Research output: Contribution to journal › Article › peer-review
-
Palladium and Platinum 2,4-cis-amino Azetidine and Related Complexes
Yoshizawa, A., Feula, A., Leach, A. G., Male, L. & Fossey, J. S., 21 Jun 2018, In: Frontiers in Chemistry. 6Research output: Contribution to journal › Article › peer-review
Open Access -
Quantitative Prediction of Rate Constants for Aqueous Racemization To Avoid Pointless Stereoselective Syntheses
Ballard, A., Ahmad, H. O., Narduolo, S., Rosa, L., Chand, N., Cosgrove, D. A., Varkonyi, P., Asaad, N., Tomasi, S., Buurma, N. J. & Leach, A. G., 22 Jan 2018, In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 57, 4, p. 982-985Research output: Contribution to journal › Article › peer-review
-
Rigid and concave, 2,4-cis-substituted azetidine derivatives: A platform dfor asymmetric catalysis
Yoshizawa, A., Feula, A., Male, L., Leach, A. G. & Fossey, J. S., 25 Apr 2018, In: Scientific Reports. 8Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Base-Catalyzed Aryl-B(OH)(2) Protodeboronation Revisited: From Concerted Proton Transfer to Liberation of a Transient Aryl Anion
Cox, P. A., Reid, M., Leach, A. G., Campbell, A. D., King, E. J. & Lloyd-Jones, G. C., 20 Sept 2017, In: Journal of the American Chemical Society. 139, 37, p. 13156-13165Research output: Contribution to journal › Article › peer-review
Open Access -
Crystallisation of aspirin via simulated pulmonary surfactant monolayers and lung-specific additives
Davies, M. J., Taylor, Z., Leach, A. G., Ren, J. & Gibbons, P., Sept 2017, In: Surface and Interface Analysis. 49, 9, p. 864-872Research output: Contribution to journal › Article › peer-review
Open Access -
The pH dependent interaction between nicotine and simulated pulmonary surfactant monolayers with associated molecular modelling
Davies, M. J., Leach, A. G., Fullwood, D., Mistry, D. & Hope, A., Sept 2017, In: Surface and Interface Analysis. 49, 9, p. 919-927Research output: Contribution to journal › Article › peer-review
Open Access -
Turbocharging Matched Molecular Pair Analysis: Optimizing the Identification and Analysis of Pairs
Lukac, I., Zarnecka, J., Griffen, E. J., Dossetter, A. G., St-Gallay, S. A., Enoch, S. J., Madden, J. C. & Leach, A. G., 23 Oct 2017, In: Journal of Chemical Information and Modeling. 57, 10, p. 2424-2436Research output: Contribution to journal › Article › peer-review
-
2016
MIDA boronates are hydrolysed fast and slow by two different mechanisms
Gonzalez, J. A., Ogba, O. M., Morehouse, G. F., Rosson, N., Houk, K. N., Leach, A. G., Cheong, P. H.-Y., Burke, M. D. & Lloyd-Jones, G. C., Nov 2016, In: Nature Chemistry. 8, 11, p. 1067-1075Research output: Contribution to journal › Article › peer-review
-
Protodeboronation of Heteroaromatic, Vinyl, and Cyclopropyl Boronic Acids: pH-Rate Profiles, Autocatalysis, and Disproportionation
Cox, P. A., Leach, A. G., Campbell, A. D. & Lloyd-Jones, G. C., 27 Jul 2016, In: Journal of the American Chemical Society. 138, 29, p. 9145-9157Research output: Contribution to journal › Article › peer-review
-
2015
A mechanistic proposal for the protodeboronation of neat boronic acids: boronic acid mediated reaction in the solid state
Noonan, G. & Leach, A. G., 2015, In: Organic & biomolecular chemistry. 13, 9, p. 2555-2560 6 p.Research output: Contribution to journal › Article › peer-review
-
Designing Hydroxamates and Reversed Hydroxamates to Inhibit Zinc-containing Proteases but not Cytochrome P450s: Insights from Quantum Mechanics and Protein-ligand Crystal Structures
Barker, C., Lukac, I. & Leach, A. G., Sept 2015, In: Molecular Informatics. 34, 9, p. 608-614 7 p.Research output: Contribution to journal › Article › peer-review
-
Novel N-thiazolyl piperazine-1-carboxamide CCR2 antagonists - investigation of an unexpected reaction with glutathione
Cumming, J. G., MacFaul, P. A. & Leach, A. G., 2015, In: MedChemComm. 6, 12, p. 2140-2145 6 p.Research output: Contribution to journal › Article › peer-review
-
2014
Circumventing Seizure Activity in a Series of G Protein Coupled Receptor 119 (GPR119) Agonists
Scott, J. S., Bowker, S. S., Brocklehurst, K. J., Brown, H. S., Clarke, D. S., Easter, A., Ertan, A., Goldberg, K., Hudson, J. A., Kavanagh, S., Laber, D., Leach, A. G., MacFaul, P. A., Martin, E. A., McKerrecher, D., Schofield, P., Svensson, P. H. & Teague, J., 13 Nov 2014, In: Journal of Medicinal Chemistry. 57, 21, p. 8984-8998Research output: Contribution to journal › Article › peer-review
-
Predicting the activity and toxicity of new psychoactive substances: a pharmaceutical industry perspective
Leach, A. G., 2014, In: Drug Testing and Analysis. 6, 7-8, p. 739-745 7 p.Research output: Contribution to journal › Article › peer-review
-
2013
Achieving improved permeability by hydrogen bond donor modulation in a series of MGAT2 inhibitors
Scott, J. S., Berry, D. J., Brown, H. S., Buckett, L., Clarke, D. S., Goldberg, K., Hudson, J. A., Leach, A. G., MacFaul, P. A., Raubo, P. & Robb, G., Sept 2013, In: MedChemComm. 4, 9, p. 1305-1311 7 p.Research output: Contribution to journal › Article › peer-review
-
A monomeric form of iNOS can rationalise observed SAR for inhibitors of dimerisation: quantum mechanics and docking compared
Leach, A. G., Olsson, L.-L. & Warner, D. J., Jan 2013, In: MedChemComm. 4, 1, p. 180-186 7 p.Research output: Contribution to journal › Article › peer-review
-
Design and synthesis of a novel series of cyclohexyloxy-pyridyl derivatives as inhibitors of diacylglycerol acyl transferase 1
Plowright, A. T., Barton, P., Bennett, S., Birch, A. M., Birtles, S., Buckett, L. K., Butlin, R. J., Davies, R. D. M., Ertan, A., Gutierrez, P. M., Kemmitt, P. D., Leach, A. G., Svensson, P. H., Turnbull, A. V. & Waring, M. J., Jan 2013, In: MedChemComm. 4, 1, p. 151-158 7 p.Research output: Contribution to journal › Article › peer-review
-
Discovery and optimization of efficacious neutral 4-amino-6-biphenyl-7,8-dihydropyrimido[5,4-f][1,4] oxazepin-5-one diacylglycerol acyl transferase-1 (DGAT1) inhibitors
Goldberg, F. W., Birch, A. M., Leach, A. G., Groombridge, S. D., Snelson, W. L., Gutierrez, P. M., Hammond, C. D., Birtles, S. & Buckett, L. K., Jan 2013, In: MedChemComm. 4, 1, p. 165-174Research output: Contribution to journal › Article › peer-review
-
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H- pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases
Addie, M., Ballard, P., Buttar, D., Crafter, C., Currie, G., Davies, B. R., Debreczeni, J., Dry, H., Dudley, P., Greenwood, R., Johnson, P. D., Kettle, J. G., Lane, C., Lamont, G., Leach, A., Luke, R. W. A., Morris, J., Ogilvie, D., Page, K. & Pass, M. & 2 others, , 14 Mar 2013, In: Journal of Medicinal Chemistry. 56, 5, p. 2059-2073 14 p.Research output: Contribution to journal › Article › peer-review