Andrew Pierce

Search results

• 2023

  Quantitative SWATH-based proteomic profiling of urine for the identification of endometrial cancer biomarkers in symptomatic women

  Njoku, K., Pierce, A., Geary, B., Campbell, A. E., Kelsall, J., Reed, R., Armit, A., Da sylva, R., Zhang, L., Agnew, H., Baricevic-Jones, I., Chiasserini, D., Whetton, A. D. & Crosbie, E. J., 17 Feb 2023, (E-pub ahead of print) In: British Journal of Cancer.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Woman 100%
  • Urine 83%
  • Endometrial Cancer 83%
  • Endometrium Cancer 83%
  • Patient 66%
• 2021

  Comprehensive library generation for identification and quantification of endometrial cancer protein biomarkers in cervico-vaginal fluid

  Njoku, K., Chiasserini, D., Geary, B., Pierce, A., Jones, E. R., Whetton, A. & Crosbie, E., 23 Jul 2021, In: Cancers.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Mass Spectrum 100%
  • Biological Marker 100%
  • Endometrial Cancer 100%
  • Vaginal Discharge 75%

• Metabolomic biomarkers for the detection of obesity-driven endometrial cancer

  Njoku, K., Campbell, A., Geary, B., Mackintosh, M., Derbyshire, A., Kitson, S., Sivalingam, V., Pierce, A., Whetton, A. & Crosbie, E., 6 Feb 2021, (Accepted/In press) In: Cancers.

  Research output: Contribution to journal › Article › peer-review

  • Endometrial Cancer 100%
  • Endometrium Cancer 100%
  • Metabolomics 33%
  • Cancer Diagnosis 33%
  • Biological Marker 33%
• 2020

  EVI1 oncoprotein expression and CtBP1 association oscillate through the cell cycle

  Paredes, R., Schneider, M., Pearson, S., Teng, H-Y., Kelly, J., Pierce, A., Somervaille, T., Whetton, A. & Meyer, S., 5 Sep 2020, (Accepted/In press) In: Molecular Biology Reports.

  Research output: Contribution to journal › Article › peer-review

• EVI1-phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal

  Paredes, R., Kelly, J., Geary, B., Almarzouq, B., Schneider, M., Pearson, S., Narayanan, P., Williamson, A., Lovell, S., Wiseman, D., Chadwick, J., Jones, N. J., Kustikova, O., Schambach, A., Garner, T., Amaral, F., Pierce, A., Stevens, A., Somervaille, T., Whetton, A., & 1 othersMeyer, S., 20 Oct 2020, In: Cell Death and Disease. 11, 878 (2020).

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2019

  AXL inhibition extinguishes primitive JAK2 mutated myeloproliferative neoplasm progenitor cells

  Pearson, S., Blance, R., Somervaille, T., Whetton, A. & Pierce, A., 24 Apr 2019, In: HemaSphere.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Janus Kinase 100%
  • Polycythemia vera 66%
  • Myeloid 66%
  • Therapeutic Procedure 50%
  • Diseases 50%

• Oncogenic MYC amplifies mitotic perturbations

  Taylor, S., Littler, S., Sloss, O., Geary, B., Pierce, A. & Whetton, A., 28 Aug 2019, In: Open Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chromosome Instability 100%
  • Mitosis 66%
  • Drive 66%
  • PLK1 66%
  • Proteomics 33%

• Proteomic analysis of an induced pluripotent stem cell model reveals strategies to treat Juvenile Myelomonocytic Leukaemia

  Pearson, S., Guo, B., Pierce, A., Azadbakht, N., Brazzatti, J. A., Patassini, S., Mulero-navarro, S., Meyer, S., Flotho, C., Gelb, B. D. & Whetton, A. D., 2019, In: Journal of Proteome Research.

  Research output: Contribution to journal › Article › peer-review

  • PTPN11 100%
  • Proteomics 75%
  • Incidence 75%
  • Mutation 75%
  • Induced Pluripotent Stem Cell 75%
• 2018

  EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association

  Paredes, R., Schneider, M., Stevens, F., White, D., Williamson, A. J. K., Muter, J., Pearson, S., Kelly, J., Connors, K., Wiseman, D., Chadwick, J., Loffler, H., Teng, H. Y., Lovell, S., Unwin, R., Van De Vrugt, H. J., Smith, H., Kustikova, O., Schambach, A., Somervaille, T., & 3 othersPierce, A., Whetton, A. & Meyer, S., 6 Sep 2018, In: Nucleic acids research. 46, 15, p. 7662-7674

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stress 100%
  • Phosphorylation 100%
  • Carboxy Terminal Sequence 75%
  • C-Terminus 75%
  • Association 50%
• 2017

  Acquired cross linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption

  Meyer, S., Stevens, F., Paredes, R., Schneider, M., Walker, M., Williamson, A., Gonzalez-Sanchez, M., Smetsers, S., Dalal, V., Teng, H-Y., White, D., Taylor, S., Muter, J., Pierce, A., De Leonibus, C., Rockx, D. AP., Rooimans, M., Spooncer, E., Stauffer, S., Biswas, K., & 5 othersGodthelp, B., Dorsman, J., Clayton, P., Sharan, S. K. & Whetton, A., 2017, In: CELL DEATH & DISEASE. 8, e2875.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • BRCA2 100%
  • Mutation 50%
  • Phenotype 25%
  • Drug Resistance 25%
  • BRCA2 Protein 25%

• Proteomic analysis of JAK2V617F induced changes identifies 2 potential new combinatorial therapeutic approaches

  Pearson, S., Williamson, A., Blance, R., Somervaille, T., Taylor, S., Azadbakht, N., Whetton, A. & Pierce, A., 2017, In: Leukemia.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteomics 100%
  • Electric Potential 100%
  • Protein 100%
  • P53 100%
  • Janus Kinase 2 66%
• 2016

  Development of a Selected Reaction Monitoring Mass Spectrometry-Based Assay to Detect Asparaginyl Endopeptidase Activity in Biological Fluids

  Dutta, A., Potier, D. N., Walker, M. J., Gray, O., Parker, C., Holland, M., Williamson, A. J. K., Pierce, A., Unwin, R., Krishnan, S., Saha, V. & Whetton, A., 23 Sep 2016, In: Oncotarget. 7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Liquid 100%
  • Protein 80%
  • Proteases 80%
  • Endopeptidase 80%
  • Development 40%

• Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

  Abraham, S. A., Hopcroft, L. E. M., Carrick, E., Drotar, M. E., Dunn, K., Williamson, A. J. K., Korfi, K., Baquero, P., Park, L. E., Scott, M. T., Pellicano, F., Pierce, A., Copland, M., Nourse, C., Grimmond, S. M., Vetrie, D., Whetton, A. & Holyoake, T. L., 16 Jun 2016, In: Nature. 534, 7607, p. 341-346 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • P53 100%
  • Protein P53 100%
  • Kinase 66%
  • Myeloid 66%
  • Chronic Myeloid Leukemia 66%
  145 Downloads (Pure)

• ERK and AKT phosphorylation status in lung cancer and emphysema using nanocapillary isoelectric focusing.

  Crosbie, P., Crosbie, E., Aspinall-O'Dea, M., Walker, M., Harrison, R., Pernemalm, M., Shah, R., Joseph, L., Booton, R., Pierce, A. & Whetton, A., 17 Feb 2016, In: B M J Open Respiratory Research. 3, 1, p. e000114

  Research output: Contribution to journal › Article › peer-review

  • Emphysema 100%
  • Lung 85%
  • Tissues 71%
  • Phosphorylation 71%
  • Neoplasm 57%

• MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5

  Whetton, A. D., Azmi, N. C., Pearson, S., Jaworska, E., Zhang, L., Blance, R., Kendall, A. C., Nicolaou, A., Taylor, S., Williamson, A. J. K. & Pierce, A., 23 Feb 2016, In: Oncotarget. 7, 10, p. 10739-55

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cells 100%
  • Therapeutic Procedure 66%
  • Secretion (Process) 66%
  • Proteomics 66%
  • Phosphorylation 66%
• 2014

  A hierarchical statistical modeling approach to analyze proteomic isobaric tag for relative and absolute quantitation data

  Zhou, C., Walker, M., Williamson, A. J. K., Pierce, A., Berzuini, C., Dive, C. & Whetton, A. D., 15 Feb 2014, In: Bioinformatics. 30, 4, p. 549-558 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Isobaric Tag for Relative and Absolute Quantitation 85%
  • Data Analysis 57%
  • Biological Product 42%
  • Mouse 28%

• Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines.

  Aspinall-O'Dea, M., Pierce, A., Pellicano, F., Williamson, A., Scott, M. T., Walker, M. J., Holyoake, T. L. & Whetton, A., 18 Dec 2014, In: Nature protocols. 10, 1, p. 149–168

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Phosphorylation 60%
  • Antibody 40%
  • Myeloid 40%
  • Tyrosine Kinase 20%

• The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors.

  Pellicano, F., Scott, M. T., Helgason, G. V., Hopcroft, L. E. M., Allan, E. K., Aspinall-O'Dea, M., Copland, M., Pierce, A., Huntly, B. J. P., Whetton, A. & Holyoake, T. L., Sep 2014, In: Stem Cells. 32, 9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myeloid 100%
  • Chronic Myeloid Leukemia 100%
  • Protein Tyrosine Kinase Inhibitor 77%
  • Tyrosine Kinase Inhibitor 55%
  • Nested Gene 22%

• THOC5 controls 3'end-processing of immediate early genes via interaction with polyadenylation specific factor 100 (CPSF100).

  Tran, D. D. H., Saran, S., Williamson, A., Pierce, A., Dittrich-Breiholz, O., Wiehlmann, L., Koch, A., Whetton, A. & Tamura, T., 29 Oct 2014, In: Nucleic acids research. 42, 19

  Research output: Contribution to journal › Article › peer-review

  • Immediate Early Gene 100%
  • Nested Gene 80%
  • Polyadenylation 80%
  • Gene 80%
  • Cells 60%
• 2013

  A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5

  Griaud, F., Pierce, A., Gonzalez Sanchez, M. B., Scott, M., Abraham, S. A., Holyoake, T. L., Tran, D. D. H., Tamura, T. & Whetton, A. D., Apr 2013, In: Leukemia. 27, 4, p. 932-940 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphorylation 100%
  • Messenger RNA 33%
  • Myeloid 33%
  • Protein-Tyrosine Kinase 33%
  • Gene Expression 16%

• A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility

  Williamson, A. J. K., Pierce, A., Jaworska, E., Zhou, C., Aspinall-O'dea, M., Lancashire, L., Unwin, R. D., Abraham, S. A., Walker, M. J., Cadecco, S., Spooncer, E., Holyoake, T. L. & Whetton, A. D., Nov 2013, In: Molecular and Cellular Proteomics. 12, 11, p. 3319-3329 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphorylation 100%
  • Cell Motility 100%
  • PTPRC 100%
  • Regulatory Mechanism 75%
  • Proteomics 50%

• Correction: Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation (PLoS ONE)

  Pierce, A., Williamson, A., Jaworska, E., Griffiths, J. R., Taylor, S., Walker, M., Aspinall O'Dea, M., Spooncer, E., Unwin, R. D., Poolman, T., Ray, D. & Whetton, A. D., 27 Jun 2013, In: PLoS ONE. 8, 6

  Research output: Contribution to journal › Article › peer-review

• Phosphorylation of the Leukemic Oncoprotein EVI1 on Serine 196 Modulates DNA Binding, Transcriptional Repression and Transforming Ability

  White, D. J., Unwin, R. D., Bindels, E., Pierce, A., Teng, H. Y., Muter, J., Greystoke, B., Somerville, T. D., Griffiths, J., Lovell, S., Somervaille, T. C. P., Delwel, R., Whetton, A. D. & Meyer, S., 12 Jun 2013, In: PLoS ONE. 8, 6, e66510.

  Research output: Contribution to journal › Article › peer-review

  • Serine 100%
  • Phosphorylation 80%
  • Zinc Finger Motif 60%
  • Protein 40%
  • Myeloid 40%

• Transglutaminase 2 expression in acute myeloid leukemia: Association with adhesion molecule expression and leukemic blast motility

  Pierce, A., Whetton, A. D., Meyer, S., Ravandi-Kashani, F., Borthakur, G., Coombes, K. R., Zhang, N. & Kornblau, S., Jul 2013, In: Proteomics. 13, 14, p. 2216-2224 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Transglutaminase 100%
  • Myeloid 87%
  • Protein 37%
  • Proteomics 25%
  • Association 25%
• 2012

  A pathway from leukaemogenic oncogenes and stem cell chemokines to RNA processing via THOC5

  Griaud, F., Pierce, A., Sanchez, M. B. G., Scott, M., Abraham, S. A., Holyoake, T. L., Tran, D. D. H., Tamura, T. & Whetton, A. D., Sep 2012, In: Leukemia. 27, p. 932-40

  Research output: Contribution to journal › Article › peer-review

• A pathway from leukaemogenic oncogenes and stem cell chemokines to RNA processing via THOC5. Accepted September 2012.

  Griaud, F., Pierce, A., Sanchez, M. B. G., Scott, M., Abraham, S. A., Holyoake, T. L., Tran, D. D. H., Tamura, T. & Whetton, A. D., Sep 2012, In: Leukemia.

  Research output: Contribution to journal › Article › peer-review

• BCR/ABL modulates protein phosphorylation associated with the etoposide-induced DNA damage response

  Griaud, F., Williamson, A. J. K., Taylor, S., Potier, D. N., Spooncer, E., Pierce, A. & Whetton, A. D., 2012, In: Journal of Proteomics. 77, p. 14-26 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Myeloid 100%
  • DNA Damage 66%
  • Transcription Factor 66%
  • Protein Phosphorylation 66%
  • Development 33%
  148 Downloads (Pure)

• Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation

  Pierce, A., Williamson, A., Jaworska, E., Griffiths, J. R., Taylor, S., Walker, M., O'Dea, M. A., Spooncer, E., Unwin, R. D., Poolman, T., Ray, D. & Whetton, A. D., 22 Jun 2012, In: PLoS ONE. 7, 6, e38928.

  Research output: Contribution to journal › Article › peer-review

  • Kinase 100%
  • Protein 85%
  • Proteomics 42%
  • Glucocorticoid Receptor 42%
  • Nuclear Protein 42%

• Triangulation proteomics identifies DNA mismatch repair as one of several nuclear targets for six leukemogenic tyrosine kinases

  Pierce, A., Williamson, A., Jaworska, E., Griffiths, J. R., Taylor, S., Walker, M., O’Dea, M. A., Spooncer, E., Unwin, R. D. & Whetton, A. D., Jun 2012, In: PLoS ONE.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches

  Lee, C. F., Griffiths, S., Rodríguez-Suárez, E., Pierce, A., Unwin, R. D., Jaworska, E., Evans, C. A., Gaskell, S. J. & Whetton, A. D., Sep 2010, In: Proteomics. 10, 18, p. 3321-3342 21 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Protein-Tyrosine Kinase 60%
  • Proteomics 40%
  • Phosphorylation 40%
  • Electric Potential 20%

• Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: Activation of the interferon response pathways

  Dobbin, E., Graham, C., Freeburn, R. W., Unwin, R. D., Griffiths, J. R., Pierce, A., Whetton, A. D. & Wheadon, H., Nov 2010, In: Stem Cell Research. 5, 3, p. 226-243 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Stem Cell 100%
  • Interferon 75%
  • Gamma Interferon 75%
  • Interferon Gamma 75%
  • Analysis 50%
• 2009

  THOC5 couples M-CSF receptor signaling to transcription factor expression

  Carney, L., Pierce, A., Rijnen, M., Sanchez, M. B. G., Hamzah, H. G., Zhang, L., Tamura, T. & Whetton, A. D., Feb 2009, In: Cell Signal. 21, 2, p. 309-316 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Colony Stimulating Factor 1 100%
  • Macrophage Colony-Stimulating Factor 100%
  • Development 50%
  • Differentiation 50%
  • Receptor 50%
• 2008

  Eight-channel iTRAQ enables comparison of the activity of six leukemogenic tyrosine kinases

  Pierce, A., Unwin, R. D., Evans, C. A., Griffiths, S., Carney, L., Zhang, L., Jaworska, E., Lee, C-F., Blinco, D., Okoniewski, M. J., Miller, C. J., Bitton, D. A., Spooncer, E. & Whetton, A. D., May 2008, In: Molecular and Cellular Proteomics. 7, 5, p. 853-863 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Protein-Tyrosine Kinase 100%
  • Proteomics 75%
  • Proteome 75%
  • Kinase 50%

• THOC5 spliceosome protein: A target for leukaemogenic tyrosine kinases that affects inositol lipid turnover

  Pierce, A., Carney, L., Hamza, H. G., Griffiths, J. R., Zhang, L., Whetton, B. A., Sanchez, M. B. G., Tamura, T., Sternberg, D. & Whetton, A. D., Jun 2008, In: British Journal of Haematology. 141, 5, p. 641-650 9 p.

  Research output: Contribution to journal › Article › peer-review

  • PDGFRB 100%
  • Protein 50%
  • Phosphorylation 33%
  • Kinase 33%
  • Growth Factor 33%
• 2006

  A novel mechanism for BCR-ABL action: Stimulated secretion of CCN3 is involved in growth and differentiation regulation

  McCallum, L., Price, S., Planque, N., Perbal, B., Pierce, A., Whetton, A. D. & Irvine, A. E., 1 Sep 2006, In: Blood. 108, 5, p. 1716-1723 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Kinase 100%
  • Phosphotransferase 100%
  • Secretion (Process) 75%
  • Myeloid 75%
  • Imatinib 75%

• Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation

  Pierce, A., Lu, Y., Hamzah, H. G., Thompson, S., Owen-Lynch, P. J., Whetton, A. D. & Spooncer, E., May 2006, In: British Journal of Haematology. 133, 3, p. 345-352 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Stromal Cell-Derived Factor 1 100%
  • Kinase 25%
  • Tyrosine 25%
  • Actin 25%
  • Second Messenger System 25%

• Quantitative proteomics reveals posttranslational control as a regulatory factor in primary hematopoietic stem cells

  Unwin, R. D., Smith, D. L., Blinco, D., Wilson, C. L., Miller, C. J., Evans, C. A., Jaworska, E., Baldwin, S. A., Barnes, K., Pierce, A., Spooncer, E. & Whetton, A. D., 15 Jun 2006, In: Blood. 107, 12, p. 4687-4694 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Proteome 100%
  • Proteomics 40%
  • Protein 40%
  • Peptide 40%
  • Hematopoietic Stem Cell 40%

• Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance

  Underhill-Day, N., Pierce, A., Thompson, S. E., Xenaki, D., Whetton, A. D. & Owen-Lynch, P. J., Mar 2006, In: British Journal of Haematology. 132, 6, p. 774-783 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor Tyrosine Kinase 100%
  • C-Terminus 100%
  • BCR ABL Protein 83%
  • Actin 33%
  • Protein 33%
• 2005

  Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P3) and lack a PtdIns(3,4,5)P3 response to cytokines and chemotactic factors; effects reversed by imatinib

  Hamzah, H. G., Pierce, A., Stewart, W. A., Peter Downes, C., Gray, A., Irvine, A., Spooncer, E. & Whetton, A. D., Oct 2005, In: Leukemia. 19, 10, p. 1851-3 3 p.

  Research output: Contribution to journal › Article › peer-review

• Global effects of BCR/ABL and TEL/PDGFRβ expression on the proteome and phosphoproteome: Identification of the Rho pathway as a target of BCR/ABL

  Unwin, R. D., Sternberg, D. W., Lu, Y., Pierce, A., Gilliland, D. G. & Whetton, A. D., 25 Feb 2005, In: Journal of Biological Chemistry. 280, 8, p. 6316-6326 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Kinase 100%
  • Imatinib 100%
  • Proteome 100%
  • Cytoskeleton Protein 100%

• Hypoxia-induced down-regulation of BRCA1 expression by E2Fs

  Bindra, R. S., Gibson, S. L., Meng, A., Westermark, U., Jasin, M., Pierce, A. J., Bristow, R. G., Classon, M. K. & Glazer, P. M., 15 Dec 2005, In: Cancer Research. 65, 24, p. 11597-11604 8 p.

  Research output: Contribution to journal › Article › peer-review

  • BRCA1 100%
  • Homologous Recombination 42%
  • Genetics 28%
  • Gene Mutation 28%
  • Defense Mechanism 28%

• Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells

  Unwin, R. D., Pierce, A., Watson, R. B., Sternberg, D. W. & Whetton, A. D., Jul 2005, In: Molecular and Cellular Proteomics. 4, 7, p. 924-935 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Peptide 83%
  • Sample 50%
  • Mammalian Cell 16%
  • Electric Potential 16%
• 2004

  Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: A role for PKCβII

  Xenaki, D., Pierce, A., Underhill-Day, N., Whetton, A. D. & Owen-Lynch, P. J., Feb 2004, In: Cellular Signalling. 16, 2, p. 145-156 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein-Tyrosine Kinase 100%
  • Protein Kinase C 42%
  • Survival 28%
  • Isoform 28%
  • Apoptosis 28%

• Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility

  Evans, C. A., Tonge, R., Blinco, D., Pierce, A., Shaw, J., Lu, Y., Hamzah, H. G., Gray, A., Downes, C. P., Gaskell, S. J., Spooncer, E. & Whetton, A. D., 15 May 2004, In: Blood. 103, 10, p. 3751-3759 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Stromal Cell-Derived Factor 1 50%
  • Proteomics 33%
  • Phosphoinositide 3-Kinase 33%
  • Sample 33%
• 2003

  Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate

  Lee, C., Evans, C. A., Spooncer, E., Pierce, A., Mottram, R. & Whetton, A. D., Sep 2003, In: British Journal of Haematology. 122, 6, p. 985-995 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cells 100%
  • Stem Cell Factor 44%
  • Interleukin 3 44%
  • Cytokine 33%
  • Mouse 22%

• Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1

  Whetton, A. D., Lu, Y., Pierce, A., Carney, L. & Spooncer, E., 15 Oct 2003, In: Blood. 102, 8, p. 2798-2802 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Bone 100%
  • Kinase 66%
  • Cell Migration 66%
  • Chemotaxis 66%
  • Phosphatidylinositol 66%
• 2002

  BCR - ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor

  Pierce, A., Spooncer, E., Ainsworth, S. & Whetton, A. D., 2 May 2002, In: Oncogene. 21, 19, p. 3068-3075 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cells 100%
  • Imatinib 57%
  • Differentiation 42%
  • Chronic Myelogenous Leukemia 28%
  • Hematopoietic Cell 28%

• Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation.

  Smith, D. L., Evans, C. A., Pierce, A., Gaskell, S. J. & Whetton, A. D., Nov 2002, In: Molecular and Cellular Proteomics. 1, 11, p. 876-884 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Myeloid 100%
  • Leukotriene-A4 Hydrolase 100%
  • Protein-Tyrosine Kinase 100%
  • Proteomics 33%
  • Lysozyme 33%

• Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors

  Evans, C. A., Ariffin, S., Pierce, A. & Whetton, A. D., 1 Nov 2002, In: Blood. 100, 9, p. 3164-3174 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor 100%
  • Eicosanoid Receptor 100%
  • Receptor Subunit 57%
  • Interleukin 3 57%
  • Myeloid Differentiation 57%
• 2001

  The specific enhancement of interferon alpha induced growth inhibition by BCR/ABL only occurs in multipotent cells

  Pierce, A., Smith, D. L., Jakobsen, L. V., Whetton, A. D. & Spooncer, E., 2001, In: The Hematology Journal. 2, 4, p. 257-264 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Interferon 100%
  • Interferon Alfa 90%
  • Alpha Interferon 90%
  • Cells 36%
  • Western Blot 27%