Research output per year
Research output per year
- 1 - 50 out of 144 results
Search results
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2024
A refined, minimally invasive, reproducible ovine ischaemia-reperfusion-infarction model using implantable defibrillators: Methodology and validation
Pius, C., Niort, B., Radcliffe, E. J. & Trafford, A. W., 19 Dec 2024, (E-pub ahead of print) In: Experimental Physiology.Research output: Contribution to journal › Article › peer-review
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Brief response to Terrar
Eisner, D. A., Greensmith, D. J. & Trafford, A. W., Dec 2024, In: The Journal of physiology. 602, 24, p. 7111Research output: Contribution to journal › Article › peer-review
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BS45 Transcriptomic analysis of differential ventricular gene expression patterns in response to phosphodiesterase 5 inhibition in heart failure
Perera, T., Nik Mohd Alwi, N. A., Lawless, M., Tang, C., Hutchings, D. & Trafford, A., 27 May 2024, In: Heart. 110, Supp 3Research output: Contribution to journal › Conference article
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Calcium flux balance in the heart: how many of the important questions are really unanswered?
Eisner, D. A., Greensmith, D. J. & Trafford, A. W., Dec 2024, In: The Journal of physiology. 602, 24, p. 7103-7107 5 p.Research output: Contribution to journal › Article › peer-review
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Maladaptive Cardiomyocyte Calcium Handling in Adult Offspring of Hypoxic Pregnancy: Protection by Antenatal Maternal Melatonin
Lock, M., Patey, O. V., Smith, K., Niu, Y., Jaggs, B., Trafford, A., Giussani, D. A. & Galli, G., 21 Nov 2024, In: The Journal of Physiology.Research output: Contribution to journal › Article › peer-review
Open Access -
On the role of dysferlin in striated muscle: membrane repair, t-tubules and Ca2+ handling
Quinn, C. J., Cartwright, E. J., Trafford, A. W. & Dibb, K. M., 1 May 2024, In: The Journal of physiology. 602, 9, p. 1893-1910Research output: Contribution to journal › Article › peer-review
Open Access -
Restoring Atrial T-Tubules Augments Systolic Ca Upon Recovery From Heart Failure
Caldwell, J. L., Clarke, J. D., Smith, C. E. R., Pinali, C., Quinn, C. J., Pearman, C. M., Adomaviciene, A., Radcliffe, E. J., Watkins, A. E., Horn, M. A., Bode, E. F., Madders, G. W. P., Eisner, M., Eisner, D. A., Trafford, A. W. & Dibb, K. M., 13 Sept 2024, In: Circulation research. 135, 7, p. 739-754 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Atrial t-tubules adopt a specialist developmental state while alterations to Ca2+ buffering maintain systolic Ca2+ during postnatal development
Smith, C. E. R., Clarke, J., Quinn, C., Najem, H., Sultan, Z., Denham, N., Hutchings, D., Madders, G., Caldwell, J., Toms, L., Pinali, C., Eisner, D., Trafford, A. & Dibb, K., 2 Oct 2023, Cold Spring Harbor Laboratory Press, (bioRxiv).Research output: Preprint/Working paper › Preprint
Open Access -
Proteoglycans modulation of cardiac extracellular matrix elastic properties in health and myocardial infarction
Collado Rojas, C., Stanley, P., Pius, C., Radcliffe, E., Niort, B., Venetucci, L., Dibb, K., Trafford, A. & Pinali, C., Sept 2023.Research output: Contribution to conference › Poster › peer-review
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2022
Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart
Hulikova, A., Park, K. C., Loonat, A. A., Gunadasa-Rohling, M., Curtis, M. K., Chung, Y. J., Wilson, A., Carr, C. A., Trafford, A. W., Fournier, M., Moshnikova, A., Andreev, O. A., Reshetnyak, Y. K., Riley, P. R., Smart, N., Milne, T. A., Crump, N. T. & Swietach, P., 31 Mar 2022, In: Basic Research in Cardiology. 117, 1, 17.Research output: Contribution to journal › Article › peer-review
Open Access -
Cardiac Transverse Tubules in Physiology and Heart Failure
Dibb, K. M., Louch, W. E. & Trafford, A. W., 10 Feb 2022, In: Annual Review of Physiology. 84, 1, p. 229-255 27 p.Research output: Contribution to journal › Review article › peer-review
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Cardiomyocyte-specific loss of plasma membrane calcium ATPase 1 impacts cardiac rhythm and is associated with ventricular repolarisation dysfunction
Wilson, C., Stafford, N., Zi, M., Chelu, A., Niort, B. C., Li, Y., Baudoin, F., Prehar, S., Trafford, A. W. & Cartwright, E. J., 1 Aug 2022, In: Journal of molecular and cellular cardiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Downloads (Pure) -
Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex‐dependent manner
Smith, K. L. M., Swiderska, A., Lock, M. C., Graham, L., Iswari, W., Choudhary, T., Thomas, D., Kowash, H. M., Desforges, M., Cottrell, E. C., Trafford, A. W., Giussani, D. A. & Galli, G. L. J., 8 Aug 2022, In: Journal of Pineal Research.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhanced calcium release at specialised surface sites compensates for reduced t-tubule density in neonatal sheep atrial myocytes
Smith, C. E. R., Pinali, C., Eisner, D., Trafford, A. & Dibb, K., 26 Aug 2022, In: Journal of molecular and cellular cardiology.Research output: Contribution to journal › Article › peer-review
Open Access1 Downloads (Pure) -
Interaction of background Ca2+ influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca2+ waves in sheep heart
Hutchings, D., Madders, G., Niort, B., Bode, E., Waddell, C., Woods, L., Dibb, K., Eisner, D. & Trafford, A., 1 Mar 2022, In: JOURNAL OF PHYSIOLOGY-LONDON. 17332515.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Downloads (Pure) -
Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy
Hansell, J. A., Richter, H. G., Camm, E. J., Herrera, E. A., Blanco, C. E., Villamor, E., Patey, O. V., Lock, M. C., Trafford, A. W., Galli, G. L. J. & Giussani, D. A., 1 Jan 2022, In: Journal of Pineal Research. 72, 1, e12766.Research output: Contribution to journal › Article › peer-review
Open Access -
Peptide location fingerprinting identifies species- and tissue-conserved structural remodelling of proteins as a consequence of ageing and disease
Eckersley, A., Ozols, M., Chen, P., Tam, V., Ward, L. J., Hoyland, J. A., Trafford, A., Yuan, X.-M., Schiller, H. B., Chan, D. & Sherratt, M. J., Dec 2022, In: Matrix Biology. 114, p. 108-137 29 p., 114.Research output: Contribution to journal › Article › peer-review
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Postnatal cardiovascular morbidity following preterm pre-eclampsia: an observational study
Ormesher, L., Higson, S., Luckie, M., Roberts, S. A., Glossop, H., Trafford, A., Cottrell, E., Johnstone, E. D. & Myers, J. E., 17 Aug 2022, In: Pregnancy Hypertension.Research output: Contribution to journal › Article › peer-review
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Serial block face scanning electron microscopy reveals region dependent remodelling of transverse tubules post myocardial infarction
Perera, T. (Lead), Pius, C. (Lead), Niort, B., Radcliffe, E., Dibb, K., Trafford, A. (Corresponding) & Pinali, C. (Corresponding), 21 Nov 2022, In: Royal Society of London. Philosophical Transactions B. Biological Sciences . 377, 1864, 20210331.Research output: Contribution to journal › Article › peer-review
Open AccessFile72 Downloads (Pure) -
2021
Disordered yet functional atrial t-tubules on recovery from heart failure
Caldwell, J. L., Clarke, J. D., Smith, C. E. R., Pinali, C., Quinn, C. J., Pearman, C. M., Adomaviciene, A., Radcliffe, E. J., Watkins, A. E., Horn, M. A., Bode, E. F., Eisner, M., Eisner, D. A., Trafford, A. W. & Dibb, K. M., 28 Oct 2021, bioRxiv, p. 1-3, 3 p. (bioRxiv).Research output: Preprint/Working paper › Preprint
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Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia
Hayter, E. A., Wehrens, S. M. T., Van Dongen, H. P. A., Stangherlin, A., Gaddameedhi, S., Crooks, E., Barron, N. J., Venetucci, L. A., Neill, J. S. O., Brown, T. M., Skene, D. J., Trafford, A. W. & Bechtold, D. A., 30 Apr 2021, In: Nature Communications. 12, 1, 2472.Research output: Contribution to journal › Article › peer-review
Open Access -
Electrophysiological and Proarrhythmic Effects of Hydroxychloroquine Challenge in Guinea-Pig Hearts
Wang, G., Lu, C.-J., Trafford, A. W., Tian, X., Flores, H. M., Maj, P., Zhang, K., Niu, Y., Wang, L., Du, Y., Ji, X., Xu, Y., Wu, L., Li, D., Herring, N., Paterson, D., Huang, C.L.-H., Zhang, H., Lei, M. & Hao, G., 8 Oct 2021, In: ACS Pharmacology & Translational Science . 4, 5, p. 1639-1653 15 p.Research output: Contribution to journal › Article › peer-review
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Optimising Large Animal Models of Sustained Atrial Fibrillation: Relevance of the Critical Mass Hypothesis
Denham, N., Pearman, C., Madders, G., Smith, C. E. R., Trafford, A. & Dibb, K., 15 Jun 2021, In: Frontiers in Physiology. 690897.Research output: Contribution to journal › Article › peer-review
Open Access -
PDE5 inhibition suppresses ventricular arrhythmias by reducing SR Ca2+ content
Hutchings, D., Pearman, C., Madders, G., Woods, L., Eisner, D., Dibb, K. & Trafford, A., 12 Jul 2021, (E-pub ahead of print) In: Circulation research.Research output: Contribution to journal › Article › peer-review
Open Access -
Peptide location fingerprinting reveals tissue region‐specific differences in protein structures in an ageing human organ
Eckersley, A., Ozols, M., Chen, P., Tam, V., Hoyland, J. A., Trafford, A., Chan, D. & Sherratt, M. J., 27 Sept 2021, In: International Journal of Molecular Sciences. 22, 19, 10408.Research output: Contribution to journal › Article › peer-review
Open Access -
REGIONAL ALTERATIONS TO THE TRANSVERSE-TUBULE NETWORK IN AN OVINE MODEL OF MYOCARDIAL INFARCTION
Perera, T., Pinali, C., Radcliffe, E., Niort, B., Pius, C. & Trafford, A., Jun 2021, In: Heart. 107, p. A160-A161Research output: Contribution to journal › Meeting Abstract › peer-review
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Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation"
Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M.-C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., DeMambro, V., D'Hont, J., Dibb, K. & Eudy, J. D. & 93 others, , 7 Apr 2021, In: Genome Biology. 22, 1, p. 99Research output: Contribution to journal › Article › peer-review
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Substrate for the Myocardial Inflammation-Heart Failure Hypothesis Identified Using Novel USPIO Methodology
Lagan, J., Naish, J., Simpson, K., Zi, M., Cartwright, E., Foden, P., Morris, J., Clark, D., Birchall, L., Caldwell, J., Trafford, A., Fortune, C., Cullen, M. H., Chaudhuri, N., Fildes, J., Sarma, J., Schelbert, E. B., Schmitt, M., Piper Hanley, K. & Miller, C., 1 Feb 2021, In: JACC: Cardiovascular Imaging. 14, 2, p. 365-376 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Transverse-tubule remodelling in remote and border regions following myocardial infarction
Perera, T., Pinali, C., Radcliffe, E., Niort, B., Pius, C. & Trafford, A., 20 Aug 2021.Research output: Contribution to conference › Abstract › peer-review
Open Access -
2020
Chronic vagal nerve stimulation has no effect on tachycardia-induced heart failure progression or excitation-contraction coupling
Radcliffe, E., Pearman, C., Watkins, A., Lawless, M., Kirkwood, G., Saxton, S., Eisner, D. & Trafford, A. (Corresponding), 20 Jan 2020, In: Physiological Reports. 8, 2, e14321.Research output: Contribution to journal › Article › peer-review
Open Access -
Non-ischemic Heart Preservation via Hypothermic Cardioplegic Perfusion Induces Immunodepletion of Donor Hearts Resulting in Diminished Graft Infiltration Following Transplantation
Critchley, W. R., Stone, J. P., Liao, Q., Qin, G., Risnes, I., Trafford, A., Scott, H., Sjöberg, T., Steen, S. & Fildes, J. E., 28 Jul 2020, In: Frontiers in Immunology. 11, 1621.Research output: Contribution to journal › Article › peer-review
Open Access -
Postnatal Enalapril to Improve Cardiovascular Function Following Preterm Preeclampsia (PICk-UP): A Randomized Double-Blind Placebo-Controlled Feasibility Trial
Ormesher, L., Higson, S., Luckie, M., Roberts, S. A., Glossop, H., Trafford, A., Cottrell, E., Johnstone, E. D. & Myers, J. E., 5 Dec 2020, In: Hypertension. 76, 6, p. 1828-1837 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Sex-dependent Effects of Developmental Hypoxia on Cardiac Mitochondria from Adult Murine Offspring
Hellgren, K., Premanandhan, H., Quinn, C., Trafford, A. & Galli, G., 10 Nov 2020, In: Free Radical Biology and Medicine.Research output: Contribution to journal › Article › peer-review
Open AccessFile269 Downloads (Pure) -
The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications
Eisner, D., Trafford, A., Caldwell, J. & Hutchings, D., 31 Jan 2020, In: Circulation research. 126, 3Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Disordered yet functional atrial t-tubules on recovery from heart failure
Caldwell, J., Clarke, J., Pinali, C., Eisner, D., Trafford, A. & Dibb, K., 30 Apr 2019, p. 20. 1 p.Research output: Contribution to conference › Poster › peer-review
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Dual antiarrhythmic properties of phosphodiesterase-5 inhibitors suppress Ca2+ waves in systolic heart failure
Hutchings, D., Madders, G., Waddell, C., Woods, L., Dibb, K., Eisner, D. & Trafford, A., 2019, In: Proceedings of The Physiological Society. 43, C014.Research output: Contribution to journal › Meeting Abstract › peer-review
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Letter by Hutchings et al Regarding Article, "Preimplant Phosphodiesterase-5 Inhibitor Use Is Associated With Higher Rates of Severe Early Right Heart Failure After Left Ventricular Assist Device Implantation : An INTERMACS Analysis".
Hutchings, D., Trafford, A. & Callan, P., Sept 2019, In: Circulation: Heart Failure.Research output: Contribution to journal › Letter › peer-review
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Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure.
Lawless, M., Caldwell, J., Radcliffe, E., Smith, C., Madders, G., Hutchings, D., Woods, L., Church, S., Unwin, R., Kirkwood, G., Becker, L., Pearman, C., Taylor, R., Eisner, D., Dibb, K. & Trafford, A., 1 May 2019, In: Scientific Reports. 9, 1, 6801.Research output: Contribution to journal › Article › peer-review
Open Access -
Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation
Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M.-C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M. & Eudy, J. D. & 93 others, , 2019, In: Genome biology. 20, 1, 171.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure
Denham, N. C., Pearman, C. M., Caldwell, J. L., Madders, G. W. P., Eisner, D. A., Trafford, A. W. & Dibb, K. M., 4 Oct 2018, In: Frontiers in Physiology. 9, OCT, p. 1380 1380.Research output: Contribution to journal › Article › peer-review
Open Access -
Increased vulnerability to atrial fibrillation is associated with increased susceptibility to alternans in old sheep
Pearman, C. M., Madders, G. W. P., Radcliffe, E. J., Kirkwood, G. J., Lawless, M., Watkins, A., Smith, C. E. R., Trafford, A. W., Eisner, D. A. & Dibb, K. M., 4 Dec 2018, In: Journal of the American Heart Association. 7, 23Research output: Contribution to journal › Article › peer-review
Open Access -
Phosphodiesterase-5 inhibition with sildenafil suppresses triggered ventricular arrhythmias and calcium waves via reduced sarcoplasmic reticulum content in the large mammal
Hutchings, D., Madders, G., Pearman, C., Woods, L., Dibb, K., Eisner, D. & Trafford, A., Jul 2018, In: Journal of molecular and cellular cardiology. 120, p. 37 1 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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Phosphodiesterase-5 inhibitors and the heart: compound cardioprotection?
Hutchings, D., Anderson, S., Caldwell, J. & Trafford, A., 2018, In: Heart.Research output: Contribution to journal › Article › peer-review
Open Access1 Downloads (Pure) -
Physiology and patho-physiology of the cardiac transverse tubular system: Transverse (t)-tubules in the heart
Smith, C., Trafford, A., Caldwell, J. & Dibb, K., 1 Feb 2018, In: Current Opinion in Physiology. p. 1 15 p., COPHYS-D-17-00030R1.Research output: Contribution to journal › Article › peer-review
Open AccessFile173 Downloads (Pure) -
2017
A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions
Colman, M. A., Pinali, C., Trafford, A. W., Zhang, H. & Kitmitto, A., 31 Aug 2017, In: PLoS computational biology. 13, 8, p. e1005714Research output: Contribution to journal › Article › peer-review
Open Access -
Calcium and Excitation-Contraction Coupling in the Heart
Eisner, D., Caldwell, J., Kistamas, K. & Trafford, A., 6 Jul 2017, In: Circulation research.Research output: Contribution to journal › Article › peer-review
Open Access -
Effects of phosphodiesterase-5 inhibition with sildenafil on calcium waves in cardiac myocytes
Hutchings, D., Dibb, K., Eisner, D. & Trafford, A., 23 Feb 2017, In: The Lancet. 389, Special issue S50, 1 p.Research output: Contribution to journal › Meeting Abstract
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Increased Ca buffering underpins remodelling of Ca2+ handling in old sheep atrial myocytes
Clarke, J., Caldwell, J., Pearman, C., Eisner, D., Trafford, A. & Dibb, K., 2017, In: The Journal of Physiology. TJP12537.Research output: Contribution to journal › Article › peer-review
Open Access -
Letter by Pearman et al. regarding article, "Effect of botulinum toxin on inducibility and maintenance of atrial fibrillation in ovine myocardial tissue"
Pearman, C. M., Trafford, A. W. & Dibb, K. M., 18 Oct 2017, In: Pacing and clinical electrophysiology .Research output: Contribution to journal › Letter
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Phosphodiesterase-5 inhibition with sildenafil suppresses calcium waves by reducing sarcoplasmic reticulum content
Hutchings, D., Dibb, K., Pearman, C., Madders, G., Woods, L., Eisner, D. & Trafford, A., 1 Jun 2017, In: Heart. 103, 5, 1 p., 179.Research output: Contribution to journal › Meeting Abstract