Research output per year
Research output per year
Personal profile
Overview
I am Professor of Respiratory Medicine and Deputy Head of the Division of Infection, Immunity and Respiratory Medicine in the School of Biological Sciences. I am an Honorary Consultant Respiratory Physician at Wythensahwe Hospital (Manchester University NHS Foundation Trust) and conduct asthma and allergy clinics as well as general respiratory medicine clinics. My research focusses on early life risk factors for asthma and allergies, in particular phenotypes, endotypes and genetic epidemiology. I coordinate the MRC funded national network of five asthma birth cohort studies (Study Team for Early Life Asthma Research) and am co-investigator of the Manchester Asthma and Allergy Study. I am the asthma and allergy lead within the respiratory theme of the Manchester Biomedical Research Centre. I am an investigator on the EU funded Integrated Approaches to Food Allergen and Allergy Risk Management (iFAAM). I am chief investigator of the Manchester Allergy Respiratory and Thoracic Surgery Biobank at Wythensahwe Hospital. I am clinical lead for the Food Standards Agency funded Prevalenc of Adult Food Allergy Study.
Biography
Having completed clinical training in Respiratory and General Internal Medicine in the North West Regional Rotation, I was appointed Senior Lecturer in Asthma and Allergy Research at the University of Manchester and Honorary Consultant Respiratory Physician at Wythenshawe Hospital in January 2005. I was promoted to Professor of Respiratory Medicine in 2011. I have published extensively in the field of early life risk factors for asthma and allergy including genetic and epidemiological studies. Working with collaborators at Microsoft research, we pioneered the use of machine learning techniques in the field, to improve our understanding of phenotypes in allergic disease. I continue to collaborate with investigators at Imperial College London on the flagship award from BBSRC/MRC systems immunology of the human life course award.
Research interests
- Early life risk factors for asthma and allergies
- Gene environment interactions in respiratory disease
- Asthma diagnostics
- Food allergy
Key Words
- Asthma
- Allergy
- Genetics
- Birth cohorts
- Food allergy
Methodological knowledge
- Birth cohort studies
- Assessment of environmental exposures
- Genotyping
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
FRCP, Royal College of Physicians
Award Date: 1 May 2013
Doctor of Philosophy, Genetic and Environmental Factors in Asthma and Allergic Diseases , The University of Manchester
Award Date: 1 May 2009
Doctor of Medicine, The University of Manchester
Award Date: 1 Jun 2000
Bachelor of Medicine and Bachelor of Surgery, The University of Manchester
Award Date: 5 Jul 1991
Bachelor of Arts, Physiological Sciences (medicine), Oxford University
Award Date: 1 Jun 1988
Areas of expertise
- R Medicine (General)
- asthma
- allergy
- food allergy
- Diagnostics
- genetics
Research Beacons, Institutes and Platforms
- Digital Futures
- Lydia Becker Institute
Keywords
- asthma
- allergy
- genetics
- Epidemiology
- phenotypes
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Circulating CC16, immune response to Mycoplasma pneumoniae and lung function: a population-based, multi-cohort study
Dy, A. B. C., Voraphani, N., Spangenberg, A., Belinsky, S. A., Picchi, M. A., Melén, E., Kull, I., Simpson, A., Murray, C., Halonen, M., Ledford, J. G. & Guerra, S., 1 Apr 2025, In: Respiratory Medicine. 240, 108044.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Exploring the temporal interplay of allergic sensitization and asthma via graph and manifold analysis
Cucco, A., Simpson, A., Murray, C., Custovic, A. & Fontanella, S., 19 Feb 2025, (E-pub ahead of print) In: Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
Open Access -
Hallmarks and metabolic regulation of type 2 activated human lung macrophages
Ridley, A. J. L., Curle, A. J., Colombo, S. A. P., Hughes, J. J., Dyer, D. P., Simpson, A., Feeney, M., Cook, P. C. & MacDonald, A. S., 2 Mar 2025, bioRxiv, p. 1-32, 32 p.Research output: Preprint/Working paper › Preprint
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Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial
The RECOVERY Collaborative Group, 1 Mar 2025, In: EClinicalMedicine. 81, 103080.Research output: Contribution to journal › Article › peer-review
Open Access -
Anaphylaxis and desensitization differently activate and induce IL-8 release by mast cells in a human peanut allergy in vitro model
Tontini, C., Bahri, R., Simpson, A. & Bulfone-Paus, S., 7 Jul 2024, (E-pub ahead of print) In: Allergy.Research output: Contribution to journal › Letter › peer-review
Open Access
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NIHR Manchester Biomedical Research Centre
Bruce, I. (PI), Lord, G. (CoI), Lennon, R. (CoI), Black, G. (CoI), Wedge, D. (CoI), Morris, A. (CoI), Hussell, T. (CoI), Sharrocks, A. (CoI), Stivaros, S. (CoI), Buch, M. (CoI), Gough, J. (CoI), Kostarelos, K. (CoI), Thistlethwaite, F. (CoI), Kadler, K. (CoI), Barton, A. (CoI), Hyrich, K. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI), Vestbo, J. (CoI), Simpson, A. (CoI), Singh, S. (CoI), Smith, J. (CoI), Felton, T. (CoI), Murray, C. (CoI), Griffiths, C. (CoI), Cullum, N. (CoI), Rhodes, L. (CoI), Warren, R. (CoI), Paus, R. (CoI), Dumville, J. (CoI), Viros Usandizaga, A. (CoI), Keavney, B. (CoI), Tomaszewski, M. (CoI), Allan, S. (CoI), Body, R. (CoI), Cartwright, E. (CoI), Heagerty, A. (CoI), Kalra, P. (CoI), Miller, C. (CoI), Rutter, M. (CoI), Smith, C. (CoI), Trafford, A. (CoI), Evans, D. (CoI), Crosbie, E. (CoI), Crosbie, P. (CoI), Harvie, M. (CoI), Howell, S. (CoI), Renehan, A. (CoI), Dive, C. (CoI), Blackhall, F. (CoI), Landers, D. (CoI), Krebs, M. (CoI), Cook, N. (CoI), Clarke, R. (CoI), Taylor, S. (CoI), Jorgensen, C. (CoI), Lorigan, P. (CoI), Jayson, G. (CoI), Valle, J. (CoI), Mccabe, M. (CoI), Armstrong, A. (CoI), Freitas, A. (CoI), Illidge, T. (CoI), Choudhury, A. (CoI), Hoskin, P. (CoI), West, C. (CoI), Van Herk, M. (CoI), Faivre-Finn, C. (CoI), Bristow, R. (CoI), Kirkby, K. (CoI), Birtle, A. (CoI), Mackay, R. (CoI), Radford, J. (CoI), Linton, K. (CoI), Higham, C. (CoI), Munro, K. (CoI), Plack, C. (CoI), Arden Armitage, C. (CoI), Bruce, I. (CoI), Moore, D. (CoI), Saunders, G. (CoI), Stone, M. (CoI), Haddock, G. (CoI), Lewis, S. (CoI), Elliott, R. (CoI), Green, J. (CoI), Lovell, K. (CoI), Morrison, A. (CoI), Shaw, J. (CoI), Bucci, S. (CoI), Ainsworth, J. (CoI), Webb, R. (CoI), Newman, W. (CoI), Banka, S. (CoI), Clayton-Smith, J. (CoI), Payne, K. (CoI), Moldovan, R. (CoI), Wynn, R. (CoI) & Jones, S. (CoI)
1/12/22 → 30/11/27
Project: Research
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Application of Chronotherapy to Asthma: Towards the Personalisation of Asthma Management.
Durrington, H. (PI), Loudon, A. (CoI), Ray, D. (CoI), Simpson, A. (CoI) & Singh, S. (CoI)
1/04/19 → 31/03/22
Project: Research
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FS101174 Adult Food Allergy Research Programme
Mills, E. C. (PI), Couch, P. (CoI), Guo, H. (CoI), Simpson, A. (CoI) & Verma, A. (CoI)
1/08/18 → 31/12/22
Project: Research
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ESCAPE: ESCAPE: A European Study of Cohorts for Air Pollution Effects.
Agius, R. (PI), Lindley, S. (CoI), Mcnamee, R. (CoI) & Simpson, A. (CoI)
1/06/08 → 31/05/12
Project: Research
Datasets
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Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study
Overton, N. (Contributor), Denning, D. (Contributor), Bowyer, P. (Contributor) & Simpson, A. (Contributor), figshare , 27 Sept 2016
DOI: 10.6084/m9.figshare.c.3627629.v1, https://figshare.com/collections/Genetic_susceptibility_to_allergic_bronchopulmonary_aspergillosis_in_asthma_a_genetic_association_study/3627629/1
Dataset