Research output per year
Research output per year
Personal profile
Overview
I am Professor of Respiratory Medicine and Deputy Head of the Division of Infection, Immunity and Respiratory Medicine in the School of Biological Sciences. I am an Honorary Consultant Respiratory Physician at Wythensahwe Hospital (Manchester University NHS Foundation Trust) and conduct asthma and allergy clinics as well as general respiratory medicine clinics. My research focusses on early life risk factors for asthma and allergies, in particular phenotypes, endotypes and genetic epidemiology. I coordinate the MRC funded national network of five asthma birth cohort studies (Study Team for Early Life Asthma Research) and am co-investigator of the Manchester Asthma and Allergy Study. I am the asthma and allergy lead within the respiratory theme of the Manchester Biomedical Research Centre. I am an investigator on the EU funded Integrated Approaches to Food Allergen and Allergy Risk Management (iFAAM). I am chief investigator of the Manchester Allergy Respiratory and Thoracic Surgery Biobank at Wythensahwe Hospital. I am clinical lead for the Food Standards Agency funded Prevalenc of Adult Food Allergy Study.
Biography
Having completed clinical training in Respiratory and General Internal Medicine in the North West Regional Rotation, I was appointed Senior Lecturer in Asthma and Allergy Research at the University of Manchester and Honorary Consultant Respiratory Physician at Wythenshawe Hospital in January 2005. I was promoted to Professor of Respiratory Medicine in 2011. I have published extensively in the field of early life risk factors for asthma and allergy including genetic and epidemiological studies. Working with collaborators at Microsoft research, we pioneered the use of machine learning techniques in the field, to improve our understanding of phenotypes in allergic disease. I continue to collaborate with investigators at Imperial College London on the flagship award from BBSRC/MRC systems immunology of the human life course award.
Research interests
- Early life risk factors for asthma and allergies
- Gene environment interactions in respiratory disease
- Asthma diagnostics
- Food allergy
Key Words
- Asthma
- Allergy
- Genetics
- Birth cohorts
- Food allergy
Methodological knowledge
- Birth cohort studies
- Assessment of environmental exposures
- Genotyping
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
FRCP, Royal College of Physicians
Award Date: 1 May 2013
Doctor of Philosophy, Genetic and Environmental Factors in Asthma and Allergic Diseases , The University of Manchester
Award Date: 1 May 2009
Doctor of Medicine, The University of Manchester
Award Date: 1 Jun 2000
Bachelor of Medicine and Bachelor of Surgery, The University of Manchester
Award Date: 5 Jul 1991
Bachelor of Arts, Physiological Sciences (medicine), Oxford University
Award Date: 1 Jun 1988
Areas of expertise
- R Medicine (General)
- asthma
- allergy
- food allergy
- Diagnostics
- genetics
Research Beacons, Institutes and Platforms
- Digital Futures
- Lydia Becker Institute
Keywords
- asthma
- allergy
- genetics
- Epidemiology
- phenotypes
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Comparative phenotype of circulating versus tissue immune cells in human lung and blood compartments during health and disease
Colombo, S. A. P., Brown, S. L., Hepworth, M. R., Hankinson, J., Granato, F., Kitchen, S. J., Hussell, T., Simpson, A., Cook, P. C. & MacDonald, A. S., 19 Jul 2023, In: Discovery Immunology. 2, 1, p. kyad009Research output: Contribution to journal › Article › peer-review
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Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers
STELAR/UNICORN investigators, 1 Feb 2023, In: The Journal of allergy and clinical immunology. 151, 2, p. 423-430 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Monocyte migration profiles define disease severity in acute COVID-19 and unique features of long COVID
CIRCO, Scott, N. A., Pearmain, L., Knight, S. B., Brand, O., Morgan, D. J., Jagger, C., Harbach, S., Khan, S., Shuwa, H. A., Franklin, M., Kästele, V., Williams, T., Prise, I., McClure, F. A., Hackney, P., Smith, L., Menon, M., Konkel, J. E., Lawless, C., & 18 others, 11 May 2023, (E-pub ahead of print) In: The European respiratory journal. 61, 5, 20 p., 2202226.Research output: Contribution to journal › Article › peer-review
Open Access -
Defining the normal range of fractional exhaled nitric oxide in children – one size does not fit all: one size does not fit all
Wang, R., Fowler, S. J., Turner, S. W., Drake, S., Healy, L., Lowe, L., Wardman, H., Bennett, M., Custovic, A., Simpson, A. & Murray, C. S., 12 Sept 2022, In: ERJ Open Research. 8, 3, 00319-2022.Research output: Contribution to journal › Article › peer-review
Open Access -
Evolution of Eczema, Wheeze, and Rhinitis from Infancy to Early Adulthood Four Birth Cohort Studies
STELAR/UNICORN investigators, 15 Oct 2022, In: American Journal of Respiratory and Critical Care Medicine . 206, 8, p. 950-960 11 p.Research output: Contribution to journal › Article › peer-review
Open Access
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NIHR Manchester Biomedical Research Centre
Bruce, I., Lord, G., Lennon, R., Black, G., Wedge, D., Morris, A., Hussell, T., Sharrocks, A., Stivaros, S., Buch, M., Gough, J., Kostarelos, K., Thistlethwaite, F., Kadler, K., Barton, A., Hyrich, K., Mcbeth, J., O'Neill, T., Vestbo, J., Simpson, A., Singh, S., Smith, J., Felton, T., Murray, C., Griffiths, C., Cullum, N., Rhodes, L., Warren, R., Paus, R., Dumville, J., Viros Usandizaga, A., Keavney, B., Tomaszewski, M., Allan, S., Body, R., Cartwright, E., Heagerty, A., Kalra, P., Miller, C., Rutter, M., Smith, C., Trafford, A., Evans, D., Crosbie, E., Crosbie, P., Harvie, M., Howell, S., Renehan, A., Dive, C., Blackhall, F., Landers, D., Krebs, M., Cook, N., Clarke, R., Taylor, S., Jorgensen, C., Lorigan, P., Jayson, G., Valle, J., Mccabe, M., Armstrong, A., Freitas, A., Illidge, T., Choudhury, A., Hoskin, P., West, C., Van Herk, M., Faivre-Finn, C., Bristow, R., Kirkby, K., Birtle, A., Mackay, R., Radford, J., Linton, K., Higham, C., Munro, K., Plack, C., Arden Armitage, C., Bruce, I., Moore, D., Saunders, G., Stone, M., Haddock, G., Lewis, S., Elliott, R., Green, J., Lovell, K., Morrison, A., Shaw, J., Bucci, S., Ainsworth, J., Webb, R., Newman, W., Banka, S., Clayton-Smith, J., Payne, K., Moldovan, R., Wynn, R. & Jones, S.
1/12/22 → 30/11/27
Project: Research
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FS101174 Adult Food Allergy Research Programme
Mills, E. C., Couch, P., Guo, H., Simpson, A. & Verma, A.
1/08/18 → 31/12/22
Project: Research
Datasets
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Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study
Overton, N. (Contributor), Denning, D. (Contributor), Bowyer, P. (Contributor) & Simpson, A. (Contributor), figshare , 27 Sept 2016
DOI: 10.6084/m9.figshare.c.3627629.v1, https://figshare.com/collections/Genetic_susceptibility_to_allergic_bronchopulmonary_aspergillosis_in_asthma_a_genetic_association_study/3627629/1
Dataset