Research output per year
Research output per year
Personal profile
Research interests
My main interest is to understand the mechanisms underlying breast cancer dormancy and its regulation by the metastatic niche.
Qualifications
2012 - PhD in Biochemistry and Molecular Biology (Doctor Europeus)
Thesis title: Structure of 4F2hc ectodomain and implication of 4F2hc in tumorigenesis. Effects of butyrate and bile acids on colon adenocarcinoma cells.
Department of Biochemistry and Molecular Biology I, Complutense University of Madrid, Spain
2006 - Bsc (honors) in Biochemistry, Complutense University of Madrid, Spain
Memberships of committees and professional bodies
Member of Societies:
Spanish Association for Cancer Research (ASEICA, 2020 - present)
Biochemical Society (2019 - present)
American Association for Cancer Research (2017 - present)
Metastasis Research Society (2017 - present)
Society of Spanish Researchers in the United Kingdom (SRUK/CERU, 2015-present)
European Association for Cancer Research (2014-present)
British Association for Cancer Research (2014-present)
Spanish Biochemistry and Molecular Biology Society (2007-present)
Service on Committees:
ASEICA Postdocs Commitee (2020 - present)
SRUK/CERU Cancer Commitee (2017 - present)
Press Officer Northwest Constituency SRUK/CERU (February 2016-July 2018).
Manchester Breast Centre Postdocts/PhD students Committee (May 2015-Dec 2016).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Beacons, Institutes and Platforms
- Manchester Cancer Research Centre
Keywords
- breast cancer
- metastasis
- dormancy
- tumour microenviroment
Fingerprint
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Increased expression of interleukin-1 receptor characterizes anti-estrogen resistant ALDH+ breast cancer stem cells
Sarmiento Castro, A., Caamaño-Gutiérrez, E., Sims, A. H., Hull, N., James, M., Santiago-Gómez, A., Eyre, R., Clark, C., Brown, M. E., Brooks, M. D., Hayes, D. F., Wicha, M. S., Howell, S., Clarke, R. & M Simoes, B., 11 Aug 2020, In: Stem Cell Reports. 15, 2, p. 307-316 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer
M Simoes, B., Santiago-Gómez, A., Chiodo, C., Moreira, T., Conole, D., Lovell, S., Alferez-Castro, D., Eyre, R., Spence, K., Sarmiento Castro, A., Kohler, B., Morisset, L., Lanzino, M., Ando, S., Marangoni, E., Sims, A. H., Tate, E., Howell, S. & Clarke, R., 18 Jun 2020, In: Oncogene. 39, 25, p. 4896–4908 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
Eyre, R., Alferez-Castro, D., Santiago-Gómez, A., Spence, K., Mcconnell, J., Hart, C., M Simoes, B., Lefley, D., Tulotta, C., Storer, J., Gurney, A., Clarke, N., Brown, M., Howell, S., Sims, A. H., Farnie, G., Ottewell, P. D. & Clarke, R. B., 1 Nov 2019, In: Nature Communications. 10, 1, p. 5016 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
PAK4 regulates stemness and progression in endocrine resistant ERpositive metastatic breast cancer
Santiago-Gómez, A., Kedward, T., M Simoes, B., Dragoni, I., NicAmhlaoibh, R., Trivier, E., Sabin, V., Gee, J. M., Sims, A. H., Howell, S. J. & Clarke, R. B., 28 Aug 2019, In: Cancer Letters. 11 p., 10.1016/j.canlet.2019.05.014.Research output: Contribution to journal › Article › peer-review
Open Access -
Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP
Piggott, L., Silva, A., Robinson, T., Santiago-Gómez, A., Simões, B. M., Becker, M., Fichtner, I., Andera, L., Young, P., Morris, C., Barrett-Lee, P., Alchami, F., Piva, M., Vivanco, M. DM., Clarke, R. B., Gee, J. & Clarkson, R., 15 May 2018, In: Clinical Cancer Research. 24, 10, p. 2452-2463 12 p.Research output: Contribution to journal › Article › peer-review
Open Access
Activities
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Frontiers in Oncology (Journal)
Angelica Santiago-Gomez (Assistant editor)
2019 → 2021Activity: Publication peer-review and editorial work › Editorial work
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SRUK at the Cervantes Institute
Nicholas Weise (Co-Organiser), Beatriz Bano Otalora (Co-Organiser), Angélica Santiago-Gómez (Participant), David Ruiz (Participant), Laura Martinez Maestro (Participant) & Isabel Peset Martin (Participant)
16 Oct 2018Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc