Research output per year
Research output per year
- 18 results
Search results
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2023
Revisiting seed and soil: A new approach to target hibernating dormant tumor cells
Santiago-Gómez, A., Barkan, D. & Chambers, A. F., 30 Jan 2023, In: Frontiers in Oncology. 13, 2nd, 1126924.Research output: Contribution to journal › Editorial › peer-review
Open Access -
2020
Increased expression of interleukin-1 receptor characterizes anti-estrogen resistant ALDH+ breast cancer stem cells
Sarmiento Castro, A., Caamaño-Gutiérrez, E., Sims, A. H., Hull, N., James, M., Santiago-Gómez, A., Eyre, R., Clark, C., Brown, M. E., Brooks, M. D., Hayes, D. F., Wicha, M. S., Howell, S., Clarke, R. & M Simoes, B., 11 Aug 2020, In: Stem Cell Reports. 15, 2, p. 307-316 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer
M Simoes, B., Santiago-Gómez, A., Chiodo, C., Moreira, T., Conole, D., Lovell, S., Alferez-Castro, D., Eyre, R., Spence, K., Sarmiento Castro, A., Kohler, B., Morisset, L., Lanzino, M., Ando, S., Marangoni, E., Sims, A. H., Tate, E., Howell, S. & Clarke, R., 18 Jun 2020, In: Oncogene. 39, 25, p. 4896–4908 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
Eyre, R., Alferez-Castro, D., Santiago-Gómez, A., Spence, K., Mcconnell, J., Hart, C., M Simoes, B., Lefley, D., Tulotta, C., Storer, J., Gurney, A., Clarke, N., Brown, M., Howell, S., Sims, A. H., Farnie, G., Ottewell, P. D. & Clarke, R. B., 1 Nov 2019, In: Nature Communications. 10, 1, p. 5016 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
PAK4 regulates stemness and progression in endocrine resistant ERpositive metastatic breast cancer
Santiago-Gómez, A., Kedward, T., M Simoes, B., Dragoni, I., NicAmhlaoibh, R., Trivier, E., Sabin, V., Gee, J. M., Sims, A. H., Howell, S. J. & Clarke, R. B., 28 Aug 2019, In: Cancer Letters. 11 p., 10.1016/j.canlet.2019.05.014.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP
Piggott, L., Silva, A., Robinson, T., Santiago-Gómez, A., Simões, B. M., Becker, M., Fichtner, I., Andera, L., Young, P., Morris, C., Barrett-Lee, P., Alchami, F., Piva, M., Vivanco, M. DM., Clarke, R. B., Gee, J. & Clarkson, R., 15 May 2018, In: Clinical Cancer Research. 24, 10, p. 2452-2463 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Ethnicity influences breast cancer stem cells' drug resistance
Kamal, M., Nafie, E. H. O., Elsers, S., Alanwar, S., Ibrahim, R., Farag, F., Mlees, M., Simões, B. M., Spence, K., Santiago-Gómez, A., Salem, M. L. & Clarke, R. B., Jul 2018, In: Breast Journal. 24, 4, p. 701-703 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile156 Downloads (Pure) -
2017
Targeting IL-1 beta-Wnt signalling to prevent breast cancer colonisation in the bone microenvironment
Eyre, R., Alferez, D., Santiago-Gomez, A., Spence, K., McConnell, J., Simoes, B., Hart, C., Lefley, D., Tulotta, C., Gurney, A., Howell, S., Brown, M., Sims, A., Farnie, G., Ottewell, P. & Clarke, R., Dec 2017, In: Clinical and Experimental Metastasis. 34, 8, p. 493-493Research output: Contribution to journal › Meeting Abstract › peer-review
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2016
Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis
Eyre, R., Alférez, D. G., Spence, K., Kamal, M., Shaw, F. L., Simões, B. M., Santiago-Gómez, A., Sarmiento-Castro, A., Bramley, M., Absar, M., Saad, Z., Chatterjee, S., Kirwan, C., Gandhi, A., Armstrong, A. C., Wardley, A. M., O'Brien, C. S., Farnie, G., Howell, S. J. & Clarke, R. B., 28 Sep 2016, In: Journal of Mammary Gland Biology and Neoplasia.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
M Simoes, B., O'Brien, C., Eyre, R., Silva, A., Yu, L., Sarmiento Castro, A., Alferez-Castro, D., Spence, K., Santiago-Gomez, A., Chemi, F., Acar, A., Gandhi, A., Howell, A., Brennan, K., Rydén, L., Catalano, S., Andó, S., Gee, J., Ucar, A., Sims, A. H., & 5 others, 29 Sep 2015, In: Cell Reports. 12, 12, p. 1968-1977 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile130 Downloads (Pure) -
2014
P-cadherin intracellular signalling is dependent on α6β4 integrin activation inducing stem cell and invasive properties in human breast cancer cells
Vieira, AF., Ribeiro, AS., Dionísio, MR., Sousa, B., Nobre, R., Albergaria, A., Santiago-Gomez, A., Schmitt, F., Clarke, RB. & Paredes, J., 1 Feb 2014, In: Oncotarget. 5, 3, p. 679-692 13 p.Research output: Contribution to journal › Article › peer-review
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2013
4F2hc-silencing impairs tumorigenicity of HeLa cells via modulation of galectin-3 and β-catenin signaling, and MMP-2 expression
Santiago-Gómez, A., Barrasa, J. I., Olmo, N., Lecona, E., Burghardt, H., Palacín, M., Lizarbe, M. A. & Turnay, J., Sep 2013, In: Biochimica et biophysica acta. 1833, 9, p. 2045-56 12 p.Research output: Contribution to journal › Article › peer-review
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2012
Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells
Barrasa, J. I., Olmo, N., Santiago-Gómez, A., Lecona, E., Anglard, P., Turnay, J. & Lizarbe, M. A., Feb 2012, In: Biochimica et biophysica acta. 1823, 2, p. 570-81 12 p.Research output: Contribution to journal › Article › peer-review
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Resistance to butyrate impairs bile acid-induced apoptosis in human colon adenocarcinoma cells via up-regulation of Bcl-2 and inactivation of Bax
Barrasa, J. I., Santiago-Gómez, A., Olmo, N., Lizarbe, M. A. & Turnay, J., Dec 2012, In: Biochimica et biophysica acta. 1823, 12, p. 2201-9 9 p.Research output: Contribution to journal › Article › peer-review
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2011
Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells
Ignacio Barrasa, J., Olmo, N., Pérez-Ramos, P., Santiago-Gómez, A., Lecona, E., Turnay, J. & Antonia Lizarbe, M., Oct 2011, In: Apoptosis. 16, 10, p. 1054-67 14 p.Research output: Contribution to journal › Article › peer-review
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Structural characterization and unfolding mechanism of human 4F2hc ectodomain
Turnay, J., Fort, J., Olmo, N., Santiago-Gómez, A., Palacín, M. & Lizarbe, M. A. A., May 2011, In: Biochimica et biophysica acta. 1814, 5, p. 536-44 9 p.Research output: Contribution to journal › Article › peer-review
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2008
Kinetic analysis of butyrate transport in human colon adenocarcinoma cells reveals two different carrier-mediated mechanisms
Lecona, E., Olmo, N., Turnay, J., Santiago-Gómez, A., López de Silanes, I., Gorospe, M. & Lizarbe, M. A., 1 Jan 2008, In: The Biochemical Journal. 409, 1, p. 311-20 10 p.Research output: Contribution to journal › Article › peer-review
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2007
Acquisition of resistance to butyrate induces resistance to luminal components and other types of stress in human colon adenocarcinoma cells
Olmo, N., Turnay, J., Lecona, E., García-Díez, M., Llorente, B., Santiago-Gómez, A. & Lizarbe, M. A., Mar 2007, In: Toxicology in vitro : an international journal published in association with BIBRA. 21, 2, p. 254-61 8 p.Research output: Contribution to journal › Article › peer-review