Anna Nicolaou

2024

An adaptable in silico ensemble model of the arachidonic acid cascade

Uttley, M., Turner Horne, G., Tsigkinopoulou, A., Del Carratore, F., Hawari, A., Kiezel-Tsugunova, M., Kendall, A., Jones, J., Messenger, D., Kaur Bhogal, R., Breitling, R. & Nicolaou, A., 1 Aug 2024, In: Molecular Omics. 20, 7, p. 453-468 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Bioactive lipids in the skin barrier mediate its functionality in health and disease

Nicolaou, A. & Kendall, A., 1 Aug 2024, In: Pharmacology & therapeutics. 260, 108681.

Research output: Contribution to journal › Article › peer-review

Open Access

Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards

Torta, F., Hoffmann, N., Burla, B., Alecu, I., Arita, M., Bamba, T., Bennett, S. A. L., Bertrand-Michel, J., Brügger, B., Cala, M. P., Camacho-Munoz, M. D., Checa, A., Chen, M., Chocholoušková, M., Cinel, M., Chu-Van, E., Colsch, B., Coman, C. M., Connell, L. & Sousa, B. C. & 61 others, Dickens, A. M., Fedorova, M., Eiríksson, F. F., Gallart-Ayala, H., Ghorasaini, M., Giera, M., Guan, X. L., Haid, M., Hankemeier, T., Harms, A., Höring, M., Holčapek, M., Hornemann, T., Hu, C., Hülsmeier, A. J., Huynh, K., Jones, C. M., Ivanisevic, J., Izumi, Y., Köfeler, H. C., Lam, S. M., Lange, M., Lee, J. C., Liebisch, G., Lippa, K., Lopez-Clavijo, A. F., Manzi, M., Martinefski, M. R., Math, R. G. H., Mayor, S., Meikle, P. J., Monge, M. E., Moon, M. H., Muralidharan, S., Nicolaou, A., Nguyen-Tran, T., O’Donnell, V. B., Orešič, M., Ramanathan, A., Riols, F., Saigusa, D., Schock, T. B., Schwartz-Zimmermann, H., Shui, G., Singh, M., Takahashi, M., Thorsteinsdóttir, M., Tomiyasu, N., Tournadre, A., Tsugawa, H., Tyrrell, V. J., van der Gugten, G., Wakelam, M. J. O., Wheelock, C. E., Wolrab, D., Xu, G., Xu, T., Bowden, J. A., Ekroos, K., Ahrends, R. & Wenk, M. R., 3 Oct 2024, In: Nature Communications. 15, 1, 8562 .

Research output: Contribution to journal › Article › peer-review

Open Access

Oxylipin profiling for clinical research: Current status and future perspectives

Parchem, K., Letsiou, S., Petan, T., Oskolkova, O., Medina, I., Kuda, O., O'Donnell, V. B., Nicolaou, A., Fedorova, M., Bochkov, V. & Gladine, C., 1 Jul 2024, In: Progress in Lipid Research. 95, 101276.

Research output: Contribution to journal › Article › peer-review

Open Access

P11.010.B Zebrafish models of complex hereditary spastic paraplegia caused by variants in the Kennedy pathway gene, PCYT2

Yarwood, R., Lowe, M., Nicolaou, A. & Banka, S., 8 Jan 2024, In: European Journal of Human Genetics. 32, p. 516 1 p.

Research output: Contribution to journal › Meeting Abstract › peer-review

Open Access

Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of pneumococcal pneumonia

Feehan, K. T., Bridgewater, H. E., Stenkiewicz-Witeska, J., De maeyer, R. P. H., Ferguson, J., Mack, M., Brown, J., Ercoli, G., Mawer, C. M., Akbar, A. N., Glanville, J. R. W., Jalali, P., Bracken, O. V., Nicolaou, A., Kendall, A. C., Sugimoto, M. A. & Gilroy, D. W., 1 Dec 2024, In: Nature Communications. 15, 1, 4326.

Research output: Contribution to journal › Article › peer-review

Open Access

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2023

Identification of diurnal rhythmic blood markers in bronchial asthma.

Krakowiak, K., Maidstone, R., Chakraborty, A., Kendall, A., Nicolaou, A., Downton, P., Cristian, A.-D., Singh, D., Loudon, A., Ray, D. & Durrington, H., 3 Jul 2023, (E-pub ahead of print) In: European Respiratory Journal Open Research. 9, 4

Research output: Contribution to journal › Article › peer-review

Open Access

Plasma S1P and Sphingosine are not Different Prior to Pre-Eclampsia in Women at High Risk of Developing the Disease

Johnstone, E. D., Westwood, M., Dilworth, M., Wray, J. R., Kendall, A. C., Nicolaou, A. & Myers, J. E., 1 Jan 2023, In: Journal of Lipid Research . 64, 1, 100312.

Research output: Contribution to journal › Article › peer-review

Open Access

The lipidomic profile of the nanoparticle-biomolecule corona reflects the diversity of plasma lipids

Papafilippou, L., Nicolaou, A., Kendall, A. C., Camacho-Muñoz, D. & Hadjidemetriou, M., 14 Jul 2023, In: Nanoscale. 15, 26, p. 11038-11051 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Current insights into skin lipids and their roles in cutaneous health and disease

Nicolaou, A. & Kendall, A., 6 Dec 2022, (Accepted/In press) In: Current Opinion in Clinical Nutrition and Metabolic Care.

Research output: Contribution to journal › Article › peer-review

Genetic analyses of circulating PUFA-derived mediators identifies heritable dihydroxyeicosatrienoic acid species

McGurk, K. A., Farrell, L., Kendall, A. C., Keavney, B. D. & Nicolaou, A., Jun 2022, In: Prostaglandins and Other Lipid Mediators. 160, p. 106638

Research output: Contribution to journal › Article › peer-review

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

Trompette, A., Pernot, J., Perdijk, O., Alqahtani, R. A. A., Domingo, J. S., Camacho-Munoz, D., Wong, N. C., Kendall, A. C., Wiederkehr, A., Nicod, L. P., Nicolaou, A., von Garnier, C., Ubags, N. D. J. & Marsland, B. J., 7 Jun 2022, In: Mucosal Immunology.

Research output: Contribution to journal › Article › peer-review

Open Access

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Influence of menopause and hormone replacement therapy on epidermal ageing and skin biomechanical function

Mellody, K. T., Kendall, A. C., Wray, J. R., Foster, A. R., Langton, A. K., Costello, P., Newton, V. L., Bell, M., Griffiths, C. E. M., Nicolaou, A., Watson, R. E. B. & Pilkington, S. M., 24 Mar 2022, In: Journal of the European Academy of Dermatology and Venereology : JEADV.

Research output: Contribution to journal › Letter › peer-review

Open Access

Menopause induces changes to the stratum corneum ceramide profile, which are prevented by hormone replacement therapy

Kendall, A. C., Pilkington, S. M., Wray, J. R., Newton, V. L., Griffiths, C. E. M., Bell, M., Watson, R. E. B. & Nicolaou, A., 15 Dec 2022, (E-pub ahead of print) In: Scientific Reports. 12, 1

Research output: Contribution to journal › Article › peer-review

Open Access

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Omega-3 polyunsaturated fatty acids reverse the impact of western diets on regulatory T cell responses through averting ceramide-mediated pathways

Camacho-Muñoz, D., Niven, J., Kucuk, S., Cucchi, D., Certo, M., Jones, S. W., Fischer, D. P., Mauro, C. & Nicolaou, A., 1 Oct 2022, In: Biochemical Pharmacology. 204, p. 115211

Research output: Contribution to journal › Article › peer-review

Open Access

Ultraviolet radiation‐induced degradation of dermal extracellular matrix and protection by green tea catechins: a randomised controlled trial

Charoenchon, N., Rhodes, L. E., Nicolaou, A., Williamson, G., Watson, R. E. B. & Farrar, M. D., 13 Mar 2022, In: Clinical and Experimental Dermatology .

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Circulating ceramides as biomarkers of cardiovascular disease: evidence from phenotypic and genomic studies.

McGurk, K., Keavney, B. & Nicolaou, A., 6 May 2021, In: Atherosclerosis. 327, p. 18-30 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation

Mitchell, J. A., Shala, F., Pires, M. E. L., Loy, R. Y., Ravendren, A., Benson, J., Urquhart, P., Nicolaou, A., Herschman, H. R. & Kirkby, N. S., 19 Mar 2021, In: Science Advances. 7, 12, p. eabf6054

Research output: Contribution to journal › Article › peer-review

Open Access

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Heritability and family-based GWAS analyses of the N-acyl ethanolamine and ceramide plasma lipidome

McGurk, K., Williams, S., Guo, H., Watkins, H., Farrall, M., Cordell, H. J., Nicolaou, A. & Keavney, B., 15 Mar 2021, In: Human Molecular Genetics.

Research output: Contribution to journal › Article › peer-review

Open Access

Omega-3 carboxylic acids and fenofibrate differentially alter plasma lipid mediators in patients with non-alcoholic fatty liver disease

Camacho-Munoz, M. D., Kiezel-Tsugunova, M., Kiss, O., Uddin, M., Sundén, M., Ryaboshapkina, M., Lind, L., Oscarsson, J. & Nicolaou, A., 29 Sept 2021, (Accepted/In press) In: The FASEB Journal.

Research output: Contribution to journal › Article › peer-review

Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis

Bosini, A., Nicolaou, A., Camacho-Munoz, M. D., Kendall, A., Di Benedetto, M. G., Giacobbe, J. & Su, K.-P., 28 Apr 2021, (Accepted/In press) In: Molecular psychiatry.

Research output: Contribution to journal › Article › peer-review

2020

Circadian rhythmicity of sphingolipids in allergic asthma

Wang, R., Maidstone, R., Ray, D., Nicolaou, A., Kendall, A. & Durrington, H., 7 Sept 2020.

Research output: Contribution to conference › Paper › peer-review

Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid

Nicolaou, A. & et al., 11 Oct 2020, (E-pub ahead of print) In: Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journal › Article › peer-review

Open Access

Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO

Kwon, S. Y., Massey, K., Watson, M. A., Hussain, T., Volpe, G., Buckley, C. D., Nicolaou, A. & Badenhorst, P., 1 Feb 2020, In: Life Science Alliance. 3, 2, p. e201900356

Research output: Contribution to journal › Article › peer-review

Open Access

Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery

Fellous, T. G., Redpath, A. N., Fleischer, M. M., Gandhi, S., Hartner, S. E., Newton, M. D., François, M., Wong, S.-P., Gowers, K. H. C., Fahs, A. M., Possley, D. R., Bonnet, D., Urquhart, P., Nicolaou, A., Baker, K. C. & Rankin, S. M., 21 Feb 2020, In: Regenerative Medicine. 5, 1

Research output: Contribution to journal › Article › peer-review

Open Access

The use of missing values in proteomic data-independent acquisition mass spectrometry to enable disease activity discrimination

McGurk, K., Dagliati, A., Chiasserini, D., Lee, D., Plant, D., Baricevic-Jones, I., Kelsall, J., Eineman, R., Reed, R., Geary, B., Unwin, R., Nicolaou, A., Keavney, B., Barton, A., Whetton, A. & Geifman, N., 1 Apr 2020, In: Bioinformatics. 36, 7, p. 2217-2223 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

UV radiation recruits CD4+GATA3+ and CD8+GATA3+ Tcells while altering the lipid microenvironment following inflammatory resolution in human skin in vivo

Hawkshaw, N. J., Pilkington, S. M., Murphy, S. A., Al-Gazaq, N., Farrar, M. D., Watson, R. E., Nicolaou, A. & Rhodes, L. E., 2 Apr 2020, In: Clinical & translational immunology. 9, 4, p. e01104 e01104.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Dynamics of the human skin mediator lipidome in response to dietary omega-3 fatty acid supplementation

Kendall, A., Pilkington, S., Murphy, S., Del Carratore, F., Sunarwidhi, A. L., Kiezel-Tsugunova, M., Urquhart, P., Watson, R., Breitling, R., Rhodes, L. & Nicolaou, A., 2019, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

Dynamics of the human skin mediator lipidome in response to dietary ω-3 fatty acid supplementation

Kendall, A. C., Pilkington, S. M., Murphy, S. A., Del Carratore, F., Sunarwidhi, A. L., Kiezel-Tsugunova, M., Urquhart, P., Watson, R. E. B., Breitling, R., Rhodes, L. E. & Nicolaou, A., 13 Sept 2019, In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 13014-13027 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Heritability and family-based GWAS analyses of the circulating ceramide, endocannabinoid, and N-acyl ethanolamide lipidome

McGurk, K., Keavney, B. & Nicolaou, A., 2019.

Research output: Contribution to conference › Abstract › peer-review

Integrated eicosanoid lipidomics and gene expression reveal decreased prostaglandin catabolism and increased 5-lipoxygenase expression in aggressive subtypes of endometrial cancer: Eicosanoid metabolism in endometrial cancer

Cummings, M., Massey, K. A., Mappa, G., Wilkinson, N., Hutson, R., Munot, S., Saidi, S., Nugent, D., Broadhead, T., Wright, A. I., Barber, S., Nicolaou, A. & Orsi, N. M., Jan 2019, In: The Journal of pathology. 247, 1, p. 21-34 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Omega-3 polyunsaturated fatty acids impinge on CD4+ T cell motility and adipose tissue distribution via direct and lipid mediator-dependent effects

Cucchi, D., Camacho-muñoz, D., Certo, M., Niven, J., Smith, J., Nicolaou, A. & Mauro, C., 2019, In: Cardiovascular research.

Research output: Contribution to journal › Article › peer-review

Open Access

Rheumatoid arthritis reprograms circadian output pathways

Poolman, T. M., Gibbs, J., Walker, A. L., Dickson, S., Farrell, L., Hensman, J., Kendall, A. C., Maidstone, R., Warwood, S., Loudon, A., Rattray, M., Bruce, I. N., Nicolaou, A. & Ray, D. W., 2019, In: Arthritis Research & Therapy. 21, 1, 47.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Fatty acids and related lipid mediators in the regulation of cutaneous inflammation

Kiezel-Tsugunova, M., Kendall, A. & Nicolaou, A., 2018, In: Biochemical Society. Transactions.

Research output: Contribution to journal › Article › peer-review

Open Access

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Lipidomics for translational skin research: a primer for the uninitiated

Kendall, A. C., Koszyczarek, M. M., Jones, E. A., Hart, P. J., Towers, M., Griffiths, C. E. M., Morris, M. & Nicolaou, A., 7 May 2018, In: Experimental Dermatology. 27, 7, p. 721-728 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Oral green tea catechins do not provide photoprotection from direct DNA damage induced by higher dose solar simulated radiation: A randomized controlled trial

Farrar, M., Huq, R., Mason, S., Nicolaou, A., Clarke, K. A., Dew, T. P., Williamson, G., Watson, R. & Rhodes, L., 12 Jan 2018, In: J Am Acad Dermatol. 78, 2, p. 414-416 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Seasonal changes in epidermal ceramides are linked to impaired barrier function in acne patients

Pappas, A., Kendall, A., Brownbridge, L., Batchvarova, N. & Nicolaou, A., 2018, In: Experimental Dermatology.

Research output: Contribution to journal › Article › peer-review

Open Access

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The prostanoid pathway contains potential prognostic markers for glioblastoma

Nicolaou, A., Panagopoulos, A. T., Gomes, R. N., Almeida, F. G., da Costa Souza, F., Veiga, J. C. E. & Colquhoun, A., Jul 2018, In: Prostaglandins and Other Lipid Mediators. 137, p. 52 62 p., 137.

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

A comparison of heart rate variability, n-3 PUFA status and lipid mediator profile in age- and BMI-matched middle-aged vegans and omnivores

Pinto, A. M., Sanders, T. A. B., Kendall, A. C., Nicolaou, A., Gray, R., Al-Khatib, H. & Hall, W. L., 2017, In: British Journal of Nutrition. 117, 5, p. 669-685 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A single sunburn influences the immune component of human skin for up to 14 days

Pilkington, S., Al-Gazaq, N., Murphy, S., Nicolaou, A. & Rhodes, L., 11 Oct 2017, (Accepted/In press) Journal of Investigative Dermatology. 10S ed. Elsevier BV, Vol. 137. p. 300 1 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Do bioactive lipids play a role in leuprolide acetate treatment of endometriosis

Marshall, K., Fischer, D., Crosbie, E., Rosser, M., Kiss, O. & Nicolaou, A., 2017.

Research output: Contribution to conference › Poster › peer-review

Genetic determinants of biaoctive lipid species in a hypertension cohort

Mcgurk, K., Nicolaou, A. & Keavney, B., 29 Aug 2017, European Heart Journal. Issue suppl 1 ed. Oxford University Press, Vol. 38.

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

Open Access

Heritability and family-based GWAS analyses to discover novel lipidomic biomarkers of Cardiovascular Disease

Mcgurk, K., Nicolaou, A. & Keavney, B., 1 May 2017, British Cardiovascular Society.

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

Open Access

Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E₂

Newson, J., Motwani, M. P., Kendall, A. C., Nicolaou, A., Muccioli, G. G., Alhouayek, M., Bennett, M., Van De Merwe, R., James, S., De Maeyer, R. P. H. & Gilroy, D. W., 26 Sept 2017, In: Cell Reports. 20, 13, p. 3162-3175 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Lipid functions in skin: differential effects of n-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model

Kendall, A., Kiezel-Tsugunova, M., Brownbridge, L., Harwood, J. L. & Nicolaou, A., 2017, In: Biochimica et Biophysica Acta - Biomembranes. 10

Research output: Contribution to journal › Article › peer-review

Open Access

Lipidomics analyses of oxygenated metabolites of polyunsaturated fatty acids

Kendall, A. & Nicolaou, A., 2017, (Accepted/In press) Lipidomics. Wood, P. (ed.). Humana Press, Inc, p. 211-228 (Neuromethods; vol. 125)( Springer protocols).

Research output: Chapter in Book/Conference proceeding › Chapter

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Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signalling

Liu, W., Ruiz Velasco Hernandez, A., Wang, S., Khan, S., Zi, M., Jungmann, A., Camacho-Munoz, M. D., Guo, J., Du, G., Xie, L., Oceandy, D., Nicolaou, A., Galli, G., Müller, O. J., Cartwright, E., Ji, Y. & Wang, X., 8 Sept 2017, In: Nature Communications. 8, 494.

Research output: Contribution to journal › Article › peer-review

Open Access

P043 Ulcerative colitis is characterised by an exaggerated onset of acute inflammation with delayed resolution

Marks, D., Wysoczanski, R., Kendall, A., Motwani, M., Vega, R., Rahman, F., McCartney, S., Bloom, S., Nicolaou, A., Gilroy, D. & Segal, A., 1 Feb 2017, In: Journal of Crohn's and Colitis. 11, suppl_1, p. S99-S100

Research output: Contribution to journal › Article › peer-review

P045 5-Aminosalicylates promote inflammation resolution in ulcerative colitis through generation of anti-inflammatory hydroxy fatty acids

Wysoczanski, R., Kendall, A., Motwani, M., Vega, R., Rahman, F., McCartney, S., Bloom, S., Nicolaou, A., Gilroy, D., Segal, A. & Marks, D., 1 Feb 2017, In: Journal of Crohn's and Colitis. 11, suppl_1, p. S100-S101

Research output: Contribution to journal › Article › peer-review

Serum endocannabinoids and N-acyl ethanolamines and the influence of simulated solar UVR exposure in humans in vivo

Felton, S., Kendall, A., Almaedani, A., Urquhart, P., Webb, A., Kift, R., Vail, A., Nicolaou, A. & Rhodes, L., 2017, In: Photochemical and Photobiological Sciences. 16

Research output: Contribution to journal › Article › peer-review

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Anna Nicolaou, BSc PhD CChem FRSC

Research output

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