Research output per year
Research output per year
I have established expertise in manufacturing of nano- and micro-technologies for biomedical applications, design and modification of biomaterials, optimisation of physico-chemical and mechanical properties of biomaterials and formulation of nanoparticles.
My research group, the BioEngineered Systems research group, is highly multidisciplinary and focuses on two research interests:
1) Formulate nano- and micro-systems encapsualting therapeutics for advanced drug delivery. Current research projects focus on: nanoparticles for targeted delivery to cancer cells (e.g. receptor mediated), nanoparticles for controlled drug release.
2) Design of 3D in vitro systems replicating physiological and pathological charcteristics. Current research projects focus on: biomaterials with controlled stiffness and composition to study cell-material interaction in cancer progression, 3D systems for the release of distinctive biochemicals e.g. protein.
The ultimate aim is to develop high-throughput in vitro systems able to replicate distinctive properties of tissues to better test drug delivery and therapeutic effects.
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Annalisa started her research for the design and manufacturing of in vitro models for tissue engineering and regenerative medicine since her bachelor thesis in Bioengineering at the University of Pisa, developing a microfluidic bioreactor for toxicology drug screening and designing 3D cell laden hydrogel mimicking hepatic biomechanical cues. In 2011 she receive her PhD with the thesis entitled “Development of a modular microfabrication system to engineer complex tissues” at the University of Rome. In 2012 Annalisa joined the Institute of Clinical Physiology of the Italian National Research Council as post-doctoral research fellow, working on a FP7 project aiming at the characterisation of materials to engineer soft tissues. In 2014 Annalisa joined the University of Manchester as research associate, being appointed as Lecturer in Pharmaceutics with the School of Pharmacy (University of Manchester) few months after.
As a bioengineer I had the chance to work in different research areas during my career development. My particular research interests now focus on the design, characterisation, formulation and manufacturing of biomaterials for the development of physiologically relevant in vitro models, and development of nano-materials for drug delivery.
Highlights/Keyworkds: hydrogel, biopolymers, tissue engineering, biofabrication, 2D/3D in vitro models, microencapsulation, nanomedicine, drug delivery
My research group (BioEngineered System) is highly multidiscliplinary, with main focus on biomaterial-based projects for tissue engineering and drug delivery applications.
All research projects focus at the interface of biomaterials and biological matter.
Current group members:
Chen Zhao
Project title: Characterisation of OA-gelatin hydrogels as 3D in vitro model to study stiffness effects on breast cancer cells
Short Bio: I am a third year PhD student, with research focus on biomaterials mainly. I am developing a library of alginate-based hydrogels to control the resultant stiffness. This will help to engineer in vitro models with controlled stiffness to mimic tumour progression. This will help to study how the stiffness could influence breast cancer cell behaviour.
Keywords: Oxidized alginate, gelatin, Schiff base, stiffness, breast cancer, 3D printing
Twitter: @Huxhsjsoxj
ORCiD: orcid.org/0000-0003-3919-0668
Lekha Shah
Project title: Tumour progression in metastatic breast cancer cell lines: Engineered in vitro models
Short Bio: I am a cancer biologist working within a multi-disciplinary team of biologists, material scientists, and bioengineers. I am currently interested in developing 3D in vitro models to assess effects of physical properties and tissue mechanics (e.g. matrix stiffness, interstitial flow and shear stresses, pH, oxygen content) on metastatic breast cancer progression.
Keywords: 3D in-vitro models, Alginate hydrogels, Mechanical forces in cancer biology, Tumour-on-the-chip, Microfluidics.
Twitter: @LekhaShah10
ORCiD: 0000-0001-5533-0988
Xue Bai
Khalsa Al-Husaini
Project title: 3D cancer in vitro models
Short Bio: A first year PhD student, with research focus on the development of biomimetic 3D in vitro prostate models using 3D printing methods. Currently working on the design and characterization of alginate-based hydrogels mainly functionalization of oxidized alginate with active laminin peptides. Also prostate cancer mechanical properties are investigated using micro-CT.
Keywords: 3D in vitro models, Micro-CT, Oxidized alginate, Laminin, Prostate cancer, 3D printing
Twitter: @Husainikh
ORCiD: 0000-0003-3184-9050
Siriwat (Wat) Sukphokkit
Ponpawee (Wia) Pingrajai
Project title: Understanding the imflammatory effect of hyaluronic acid and hyaluronic acid coated nanoparticles in THP-1 macrophages
Leonidas Gkionis
Project title: Manufacturing steps towards standard and highly reproducible liposomes for advanced drug delivery to breast cancer cells
Bushra Almari
Project title: Application of amyloid-secreting cellular systems in the development of preclinical models of relevance to Alzheimer's disease
My teaching covers both material properties and manufacturing knowledge, expanding on design strategies and examples of healthcare applications.
I am currently teaching in the following modules: MED20100, PHAR40400, CHEM30441, BIOL64101.
Young Lecturer Award (2014) | Italian Group of Bioengineering
Royal Society of Chemistry, Fellow
Royal Microscopical Society, Member
Tissue Engineering and Regenerative Medicine International Society, Member
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Fellow, Institute of Clinical Physiology
Feb 2013 → Jun 2014
Lecturer in Biomaterials, Universita di Cagliari
Nov 2012 → Dec 2013
Research Associate, Universita di Pisa
Oct 2010 → Jan 2013
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to conference › Poster › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Annalisa Tirella (Chair)
Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc
Annalisa Tirella (Keynote speaker)
Activity: Talk or presentation › Invited talk
Annalisa Tirella (Chair)
Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc
Annalisa Tirella (Co-Organiser)
Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc
1/07/19
1 Media contribution
Press/Media: Research