Research output per year
Research output per year
- 50 results
Search results
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2024
Developing an in vitro model of haematoma for study of intracerebral haemorrhage
Crilly, S., Tapia, V. S., Bawn, C. & Tirella, A., 17 Apr 2024, (Accepted/In press) In: Biomaterials Science.Research output: Contribution to journal › Article › peer-review
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Targeting Hypoxia-Inducible Factor-1α in Pancreatic Cancer: siRNA Delivery Using Hyaluronic Acid-Displaying Nanoparticles
Spadea, A., Tirella, A., Rosa, J. M. R. D. L., Lallana, E., Mehibel, M., Telfer, B., Tirelli, N., Lawrence, M. J., Williams, K. J., Stratford, I. J. & Ashford, M., 30 Sept 2024, In: Pharmaceutics.Research output: Contribution to journal › Article › peer-review
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2023
Design of PLGA nanoparticles for sustained release of hydroxyl-FK866 by microfluidics
Bai, X., Tang, S., Butterworth, S. & Tirella, A., 1 Nov 2023, In: Biomaterials Advances. 154, 213649.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Arylisoquinolinones: meta-Substitution on the Aryl Ring Dramatically Enhances Antiproliferative Activity through Binding to Microtubules
Elhemely, M., Belgath, A., El Sayed, S., Burusco-Goni, K., Kadirvel, M., Tirella, A., Finegan, K., Bryce, R., Stratford, I. & Freeman, S., 15 Mar 2022, In: Journal of Medicinal Chemistry. 65, 6, p. 4783-4797Research output: Contribution to journal › Article › peer-review
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Injectable Multifunctional Natural Polymer-Based Hydrogels for the Local Delivery of Therapeutic Agents
Bai, X. & Tirella, A., 21 Dec 2022, In: International Journal of Drug Discovery and Pharmacology. p. 10 8 p., https://doi.org/10.53941/ijddp.v1i1.203.Research output: Contribution to journal › Review article › peer-review
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Invasion and secondary site colonization as a function of in vitro primary tumor matrix stiffness: breast to bone metastasis
Shah, L., Latif, A., Williams, K., Mancuso, E. & Tirella, A., 17 Oct 2022, (Accepted/In press) In: Advanced Healthcare Materials.Research output: Contribution to journal › Article › peer-review
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Role of stiffness and physico-chemical properties of tumour microenvironment on breast cancer cell stemness
Shah, L., Latif, A., Williams, K. & Tirella, A., 30 Aug 2022, (Accepted/In press) In: Acta Biomaterialia.Research output: Contribution to journal › Article › peer-review
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Sustained drug release from smart nanoparticles in cancer therapy: a comprehensive review
Bai, X., Zara L Smith, Z. L., Wang, Y., Butterworth, S. & Tirella, A., 22 Sept 2022, (Accepted/In press) In: Micromachines.Research output: Contribution to journal › Review article › peer-review
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The characterization of molecular weight distribution and aggregation by asymmetrical flow field-flow fractionation of unmodified and oxidized alginate
Zhao, C., Latif, A., Williams, K. J. & Tirella, A., 1 Jun 2022, In: Reactive and Functional Polymers. 175, 105292.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Downloads (Pure) -
2021
Additively manufactured BaTiO3 composite scaffolds: a novel strategy for load bearing bone tissue engineering applications
Mancuso, E., Shah, L., Jindal, S., Serenelli, C., Tsikriteas, Z. M., Khanbareh, H. & Tirella, A., 19 May 2021, In: Materials Science and Engineering C: Materials for Biological Applications . 112192.Research output: Contribution to journal › Article › peer-review
Open Access -
Microfluidic-assisted fabrication of phosphatidylcholine-based liposomes for controlled drug delivery of chemotherapeutics
Gkionis, L., Aojula, H., Harris, L. K. & Tirella, A., 1 Jun 2021, In: International Journal of Pharmaceutics.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Functionalized Enzyme-Responsive Biomaterials to Model Tissue Stiffening in vitro
Tirella, A., 8 Apr 2020, In: Frontiers in Bioengineering and Biotechnology. 8Research output: Contribution to journal › Article › peer-review
Open Access -
Investigation of the cytotoxicity of bioinspired coumarin analogues towards human breast cancer cells
Gkionis, L., Kavetsou, E., Kalospyros, A., Manousakis, D., Garzon Sanz, M., Butterworth, S., Detsi, A. & Tirella, A., 23 Apr 2020, In: Molecular Diversity.Research output: Contribution to journal › Article › peer-review
Open Access -
Manufacturing drug co-loaded liposomal formulations targeting breast cancer: influence of preparative method on liposomes characteristics and in vitro toxicity
Gkionis, L., Campbell, R. A., Aojula, H., Harris, L. K. & Tirella, A., 1 Oct 2020, In: International Journal of Pharmaceutics. 590, 119926.Research output: Contribution to journal › Article › peer-review
Open AccessFile122 Downloads (Pure) -
2019
Binding and internalization in receptor-targeted carriers. The complex role of CD44 in the uptake of hyaluronic acid-based nanoparticles (siRNA delivery)
Rios De La Rosa, J. M., Pingrajai, P., Pelliccia, M., Spadea, A., Lallana-Ozores, E., Gennari, A., Stratford, I., Rocchia, W., Tirella, A. & Tirelli, N., 18 Dec 2019, In: Advanced Healthcare Materials. 8, 24, 1901182.Research output: Contribution to journal › Article › peer-review
Open Access -
CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment
Tirella, A., Kloc-Muniak, K., Good, L., Ridden, J., Ashford, M., Puri, S. & Tirelli, N., 2019, In: International Journal of Pharmaceutics.Research output: Contribution to journal › Article › peer-review
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Evaluating the Efficiency of Hyaluronic Acid for Tumor Targeting via CD44
Spadea, A., Rios De La Rosa, J. M., Tirella, A., Ashford, M. B., Williams, K. J., Stratford, I. J., Tirelli, N. & Mehibel, M., 23 Apr 2019, In: Molecular Pharmaceutics. 16, 6, p. 2481–2493Research output: Contribution to journal › Article › peer-review
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Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
Almari, B., Harte, M., Brough, D. & Tirella, A., 7 Jul 2019, In: Journal of Visualized Experiments.Research output: Contribution to journal › Article › peer-review
Open Access -
Hyaluronic acid carrier-cell interactions: a tri-culture model of the tumour microenvironment to study siRNA delivery under flow conditions
Tirella, A., Rios De La Rosa, J. M. & Tirelli, N., 2019, In: International Journal of Nano and Biomaterials. 8, 2Research output: Contribution to journal › Article › peer-review
Open AccessFile59 Downloads (Pure) -
The different ways to chitosan/hyaluronic acid nanoparticles: templated vs. direct complexation. Influence of particle preparative processes on morphology, cell uptake and silencing efficiency
Gennari, A., Rios de la Rosa, J. M., Hohn, E., Pelliccia, M., Lallana, E., Donno, R., Tirella, A. & Tirelli, N., 30 Dec 2019, In: Beilstein Journal of Nanotechnology. 2019, 10, p. 2594–2608Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Colorectal tumor 3D in vitro models: advantages of biofabrication for the recapitulation of early stages of tumor development
Rios De La Rosa, J. M., Wubetu, J., Tirelli, N. & Tirella, A., 17 May 2018, In: Biomedical Physics and Engineering Express . 4, 4Research output: Contribution to journal › Article › peer-review
Open Access -
Fibroblast migration correlates with matrix softness. A study in knob-hole engineered fibrin
León Valdivieso, C., Wedgwood, J., Lallana-Ozores, E., Donno, R., Roberts, I., Ghibaudi, M., Tirella, A. & Tirelli, N., 2018, In: APL Bioengineering. 2Research output: Contribution to journal › Article › peer-review
Open Access -
Receptor‐Targeted Drug Delivery and the (Many) Problems We Know of: The Case of CD44 and Hyaluronic Acid
Rios De La Rosa, J. M., Tirella, A. & Tirelli, N., 2018, In: Advanced Biosystems.Research output: Contribution to journal › Article › peer-review
Open Access -
Relevant 3D in vitro models for drug testing
Tirella, A., 19 Dec 2018, (Accepted/In press) In: Journal of Visualized Experiments.Research output: Contribution to journal › Article › peer-review
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2017
3D BioEngineered constructs for TE cancer research
Tirella, A., 25 Jun 2017.Research output: Contribution to conference › Poster › peer-review
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Chitosan/Hyaluronic Acid Nanoparticles: Rational Design Revisited for RNA Delivery
Lallana-Ozores, E., Ríos De La Rosa, J. M., Tirella, A., Pelliccia, M., Gennari, A., Stratford, I., Puri, S., Ashford, M. & Tirelli, N., 3 Jul 2017, In: Molecular Pharmaceutics. 14, 7, p. 2422-2436 15 p.Research output: Contribution to journal › Article › peer-review
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2016
The CD44-Mediated Uptake of Hyaluronic Acid-Based Carriers in Macrophages
Gennari, A., Tirelli, N., Tirella, A., Ríos De La Rosa, J. M. & Stratford, I., 19 Dec 2016, In: Advanced Healthcare Materials. 6, 4, 1601012.Research output: Contribution to journal › Article › peer-review
Open AccessFile240 Downloads (Pure) -
2015
Corrigendum: Decoupling the role of stiffness from other hydroxyapatite signalling cues in periosteal derived stem cell differentiation.
Mattei, G., Ferretti, C., Tirella, A., Ahluwalia, A. & Mattioli-Belmonte, M., 2015, In: Scientific Reports. 5Research output: Contribution to journal › Article › peer-review
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Decoupling the role of stiffness from other hydroxyapatite signalling cues in periosteal derived stem cell differentiation.
Mattei, G., Ferretti, C., Tirella, A., Ahluwalia, A. & Mattioli-Belmonte, M., 2015, In: Scientific Reports. 5Research output: Contribution to journal › Article › peer-review
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Fibronectin localization and fibrillization are affected by the presence of serum in culture media
Siani, A., Khaw, R. R., Manley, O. W. G., Tirella, A., Cellesi, F., Donno, R. & Tirelli, N., 2015, In: Scientific Reports. 5, p. 6687-6701 14 p., 9278.Research output: Contribution to journal › Article › peer-review
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HisTOOLogy: an open-source tool for quantitative analysis of histological sections.
Magliaro, C., Tirella, A., Mattei, G., Pirone, A. & Ahluwalia, A., 10 Aug 2015, In: Journal of Microscopy.Research output: Contribution to journal › Article › peer-review
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Nano-in-Micro Self-Reporting Hydrogel Constructs.
Tirella, A., La Marca, M., Brace, L.-A., Mattei, G., Aylott, J. W. & Ahluwalia, A., Aug 2015, In: Journal of Biomedical Nanotechnology. 11, 8Research output: Contribution to journal › Article › peer-review
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2014
A multistep procedure to prepare pre-vascularized cardiac tissue constructs using adult stem sells, dynamic cell cultures, and porous scaffolds.
Pagliari, S., Tirella, A., Ahluwalia, A., Duim, S., Goumans, M.-J., Aoyagi, T. & Forte, G., 2014, In: Frontiers in Physiology. 5Research output: Contribution to journal › Article › peer-review
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A novel dual-flow bioreactor simulates increased fluorescein permeability in epithelial tissue barriers.
Giusti, S., Sbrana, T., La Marca, M., Di Patria, V., Martinucci, V., Tirella, A., Domenici, C. & Ahluwalia, A., Sept 2014, In: Biotechnology journal. 9, 9Research output: Contribution to journal › Article › peer-review
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In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response
Ucciferri, N., Collnot, E. M., Gaiser, B. K., Tirella, A., Stone, V., Domenici, C., Lehr, C. M. & Ahluwalia, A., 2014, In: Nanotoxicology. 8, 6Research output: Contribution to journal › Article › peer-review
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Mechanostructure and composition of highly reproducible decellularized liver matrices.
Mattei, G., Di Patria, V., Tirella, A., Alaimo, A., Elia, G., Corti, A., Paolicchi, A. & Ahluwalia, A., Feb 2014, In: Acta Biomaterialia. 10, 2Research output: Contribution to journal › Article › peer-review
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Sphyga: a multiparameter open source tool for fabricating smart and tunable hydrogel microbeads.
Tirella, A., Magliaro, C., Penta, M., Troncone, M., Pimentel, R. & Ahluwalia, A., Jun 2014, In: Biofabrication. 6, 2Research output: Contribution to journal › Article › peer-review
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Strain rate viscoelastic analysis of soft and highly hydrated biomaterials.
Tirella, A., Mattei, G. & Ahluwalia, A., Oct 2014, In: Journal of biomedical materials research. Part A. 102, 10Research output: Contribution to journal › Article › peer-review
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Viscoelastic characterisation of pig liver in unconfined compression.
Mattei, G., Tirella, A., Gallone, G. & Ahluwalia, A., 22 Aug 2014, In: Journal of biomechanics. 47, 11Research output: Contribution to journal › Article › peer-review
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2012
Functionally Graded Materials (FGMs) with Predictable and Controlled Gradient Profiles: Computational Modelling and Realisation
Mattei, G., Tirella, A. & Ahluwalia, A., 2012, In: Computer Modeling in Engineering & Sciences. 87, 6Research output: Contribution to journal › Article › peer-review
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Rapid prototyping composite and complex scaffolds with PAM2.
Vozzi, G., Tirella, A. & Ahluwalia, A., 2012, In: Methods in molecular biology (Clifton, N.J.). 868Research output: Contribution to journal › Article › peer-review
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Realization of a poro-elastic ultrasound replica of pulmonary tissue.
Spinelli, A., Vinci, B., Tirella, A., Matteucci, M., Gargani, L., Ahluwalia, A., Domenici, C., Picano, E. & Chiarelli, P., 2012, In: Biomatter. 2, 1Research output: Contribution to journal › Article › peer-review
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Riboflavin and collagen: New crosslinkin methods to tailor the stiffness of hydrogels
Tirella, A., Liberto, T. & Ahluwalia, A., 2012, In: Materials Letters. 74Research output: Contribution to journal › Article › peer-review
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The impact of fabrication parameters and substrate stiffness in direct writing of living constructs.
Tirella, A. & Ahluwalia, A., 2012, In: Biotechnology progress. 28, 5Research output: Contribution to journal › Article › peer-review
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The PAM2 system: a multilevel approach for fabrication of complex three-dimensional structures
Tirella, A., De Maria, C., Criscenti, G., Vozzi, G. & Ahluwalia, A., 2012, In: Rapid Prototyping Journal. 18, 4Research output: Contribution to journal › Article › peer-review
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2011
PAM2 (piston assisted microsyringe): a new rapid prototyping technique for biofabrication of cell incorporated scaffolds.
Tirella, A., Vozzi, F., Vozzi, G. & Ahluwalia, A., Feb 2011, In: Tissue Engineering. Part C. Methods. 17, 2Research output: Contribution to journal › Article › peer-review
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Substrate stiffness influences high resolution printing of living cells with an ink-jet system.
Tirella, A., Vozzi, F., De Maria, C., Vozzi, G., Sandri, T., Sassano, D., Cognolato, L. & Ahluwalia, A., Jul 2011, In: Journal of bioscience and bioengineering. 112, 1Research output: Contribution to journal › Article › peer-review
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2010
Finite element modelling and design of a concentration gradient generating bioreactor: application to biological pattern formation and toxicology.
Vozzi, G., Mazzei, D., Tirella, A., Vozzi, F. & Ahluwalia, A., Sept 2010, In: Toxicology in vitro : an international journal published in association with BIBRA. 24, 6Research output: Contribution to journal › Article › peer-review
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2009
A phase diagram for microfabrication of geometrically controlled hydrogel scaffolds.
Tirella, A., Orsini, A., Vozzi, G. & Ahluwalia, A., Dec 2009, In: Biofabrication. 1, 4Research output: Contribution to journal › Article › peer-review
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2008
A microfluidic gradient maker for toxicity testing of bupivacaine and lidocaine.
Tirella, A., Marano, M., Vozzi, F. & Ahluwalia, A., Dec 2008, In: Toxicology in vitro : an international journal published in association with BIBRA. 22, 8Research output: Contribution to journal › Article › peer-review