Ashwin Sachdeva

Search results

• 2023

  Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy: final results from two randomised phase 3 trials of the STAMPEDE platform protocol

  Attard, G., Murphy, L., Clarke, N. W., Sachdeva, A., Jones, C., Hoyle, A., Cross, W., Jones, R. J., Parker, C. C., Gillessen, S., Cook, A., Brawley, C., Gilson, C., Rush, H., Abdel-Aty, H., Amos, C. L., Murphy, C., Chowdhury, S., Malik, Z., Russell, J. M., & 30 othersParkar, N., Pugh, C., Diaz-Montana, C., Pezaro, C., Grant, W., Saxby, H., Pedley, I., O'Sullivan, J. M., Birtle, A., Gale, J., Srihari, N., Thomas, C., Tanguay, J., Wagstaff, J., Das, P., Gray, E., Alzouebi, M., Parikh, O., Robinson, A., Montazeri, A. H., Wylie, J., Zarkar, A., Cathomas, R., Brown, M. D., Jain, Y., Dearnaley, D. P., Mason, M. D., Gilbert, D., Langley, R. E. & Millman, R., 2 May 2023, In: The Lancet. Oncology. 24, 5, p. 443-456 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy: final results from two randomised phase 3 trials of the STAMPEDE platform protocol.

  STAMPEDE Investigators, 1 May 2023, In: The Lancet. Oncology.

  Research output: Contribution to journal › Article › peer-review

• Clinical testing of transcriptome-wide expression profiles in high-risk localized and metastatic prostate cancer starting androgen deprivation therapy: an ancillary study of the STAMPEDE abiraterone Phase 3 trial

  Attard, G., Parry, M., Grist, E., Mendes, L., Dutey-Magni, P., Sachdeva, A., Brawley, C., Murphy, L., Proudfoot, J., Lall, S., Liu, Y., Friedrich, S., Ismail, M., Hoyle, A., Ali, A., Haran, A., Wingate, A., Zakka, L., Wetterskog, D., Amos, C., & 26 othersAtako, N. B., Wang, V., Rush, H., Jones, R., Leung, H. Y., Cross, W., gillessen, S., Parker, C., Chowdhury, S., Lotan, T., Marafioti, T., Urbanucci, A., Schaeffer, E., Spratt, D. E., Waugh, D. J. J., Powles, T., Berney, D., Sydes, M., Parmar, M., Hamid, A., Feng, F., Sweeney, C., Davicioni, E., Clarke, N., James, N. D. & Brown, L., 8 Feb 2023

  Research output: Other contribution

  • Prostate Cancer 100%
  • Neoplasm 66%
  • Malignant Neoplasm 66%
  • Metastatic Carcinoma 66%
  • Transcriptome 66%

• European Association of Urology-American Society of Clinical Oncology Collaborative Guideline on Penile Cancer: 2023 Update

  Brouwer, O. R., Albersen, M., Parnham, A., Protzel, C., Pettaway, C. A., Ayres, B., Antunes-Lopes, T., Barreto, L., Campi, R., Crook, J., Fernández-Pello, S., Greco, I., van der Heijden, M. S., Johnstone, P. A. S., Kailavasan, M., Manzie, K., Marcus, J. D., Necchi, A., Oliveira, P., Osborne, J., & 9 othersPagliaro, L. C., Garcia-Perdomo, H. A., Rumble, R. B., Sachdeva, A., Sakalis, V. I., Zapala, Ł., Sánchez Martínez, D. F., Spiess, P. E. & Tagawa, S. T., 7 Mar 2023, (E-pub ahead of print) In: European Urology.

  Research output: Contribution to journal › Review article › peer-review

  • Penile Cancer 100%
  • Diseases 66%
  • Therapeutic Procedure 44%
  • Rare Disease 33%
  • Lymph Node 33%

• Integration of High-Throughput Imaging and Multiparametric Metabolic Profiling Reveals a Mitochondrial Mechanism of Tenofovir Toxicity

  Pearson, A., Haenni, D., Bouitbir, J., Hunt, M., Payne, B. A. I., Sachdeva, A., Hung, R. K. Y., Post, F. A., Connolly, J., Nlandu-Khodo, S., Jankovic, N., Bugarski, M. & Hall, A. M., 14 Jan 2023, In: Function. 4, 1, zqac065.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tenofovir Disoproxil 100%
  • Toxicity 60%
  • Comprehension 40%
  • Nephrotoxicity 40%
  • Therapeutic Procedure 20%

• Management of Lymph Node-positive Penile Cancer: A Systematic Review

  Sachdeva, A., McGuinness, L., Zapala, Ł., Greco, I., Garcia-Perdomo, H. A., Kailavasan, M., Antunes-Lopes, T., Ayres, B., Barreto, L., Campi, R., Crook, J., Johnstone, P., Kumar, V., Manzie, K., Marcus, J. D., Necchi, A., Oliveira, P., Osborne, J., Pagliaro, L. C., Protzel, C., & 11 othersBryan Rumble, R., Sánchez Martínez, D. F., Spiess, P. E., Tagawa, S. T., van der Heijden, M. S., Parnham, A. S., Pettaway, C. A., Albersen, M., Sangar, V. K., Brouwer, O. R. & Sakalis, V. I., 17 May 2023, (E-pub ahead of print) In: European Urology.

  Research output: Contribution to journal › Review article › peer-review

• Management of Lymph Node-positive Penile Cancer: A Systematic Review.

  Sachdeva, A., McGuinness, L., Zapala, Ł., Greco, I., Garcia-Perdomo, HA., Kailavasan, M., Antunes-Lopes, T., Ayres, B., Barreto, L., Campi, R., Crook, J., Johnstone, P., Kumar, V., Manzie, K., Marcus, JD., Necchi, A., Oliveira, P., Osborne, J., Pagliaro, LC., Protzel, C., & 11 othersBryan, R. R., Sánchez, M. DF., Spiess, PE., Tagawa, ST., van, D. H. MS., Parnham, AS., Pettaway, CA., Albersen, M., Sangar, VK., Brouwer, OR. & Sakalis, VI., 17 May 2023, In: European Urology.

  Research output: Contribution to journal › Article › peer-review

• Spatial and molecular profiling of the mononuclear phagocyte network in Classic Hodgkin lymphoma

  Stewart, B. J., Fergie, M., Young, M., Jones, C., Sachdeva, A., Blain, A. E., Bacon, C. M., Rand, V., Ferdinand, J. R., James, K. R., Mahbubani, K. T., Hook, C. E., Jonas, N., Coleman, N., Saeb-Parsy, K., Collin, M., Clatworthy, M., Behjati, S. & Carey, C. D., 7 Feb 2023, In: Blood.

  Research output: Contribution to journal › Article › peer-review

  • Macrophage 100%
  • Monocyte 55%
  • Classical Hodgkin Lymphoma 55%
  • Reed-Sternberg Cell 44%
  • Reed Sternberg Cell 44%
• 2022

  Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue

  Sachdeva, A., Hart, C. A., Carey, C. D., Vincent, A. E., Greaves, L. C., Heer, R., Oliveira, P., Brown, M. D., Clarke, N. W. & Turnbull, D. M., 22 Apr 2022, In: Scientific Reports. 12, 1, 6660.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxidative Phosphorylation 100%
  • Formaldehyde 50%
  • Immunofluorescence 50%
  • Patient 33%
  • Tissues 33%

• Integration of high-throughput imaging and multi-parametric metabolic profiling reveals a mitochondrial mechanism of tenofovir toxicity

  Pearson, A., Haenni, D., Bouitbir, J., Hunt, M., Payne, B. A. I., Sachdeva, A., Hung, R. K. Y., Post, F. A., Connolly, J., Nlandu-Khodo, S., Jankovic, N., Bugarski, M. & Hall, A., 24 Dec 2022, In: Function.

  Research output: Contribution to journal › Article › peer-review

  • Tenofovir Disoproxil 100%
  • Toxicity 60%
  • Comprehension 40%
  • Nephrotoxicity 40%
  • Therapeutic Procedure 20%

• IRF7 impacts on prostate cancer cell survival in response to radiation

  Pickard, A., Amoroso, F., McCulloch, K., Erickson, A., Sachdeva, A., Steele, R., Mukherjee, D., Dellett, M., McComb, J., McCaffery, L., Hart, C. A., Brown, M. D., McDade, S., Waugh, D., Clarke, N., Butterworth, K., Illidge, T., Mirtti, T., Overton, I. M. & Mills, I. G., 23 Sep 2022, In: bioRxiv.

  Research output: Contribution to journal › Article

• Non-canonical EphA2 activation underpins PTEN-mediated metastatic migration and poor clinical outcome in prostate cancer

  Sachdeva, A., Hart, C. A., Kim, K., Tawadros, T., Oliveira, P., Shanks, J., Brown, M. & Clarke, N., 22 Jul 2022, In: British Journal of Cancer.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bone 100%
  • Development 50%
  • Electrophysiology 50%
  • Mutant 50%
  • Phosphorylation 50%

• Spatial and molecular profiling of classic Hodgkin lymphoma reveals an immunosuppressive mononuclear phagocyte network

  Stewart, B., Fergie, M., Young, M., Jones, C., Sachdeva, A., Blain, A., Bacon, C., Rand, V., Ferdinand, J., James, K., Mahbubani, K., Hook, L., Jonas, N., Coleman, N., Saeb-Parsy, K., Collin, M., Clatworthy, M., Behjati, S. & Carey, C., 2022

  Research output: Other contribution
• 2021

  Approaches to the Rational Design of Molecularly Imprinted Polymers Developed for the Selective Extraction or Detection of Antibiotics in Environmental and Food Samples

  Jamieson, O., Mecozzi, F., Crapnell, R. D., Battell, W., Hudson, A., Novakovic, K., Sachdeva, A., Canfarotta, F., Herdes, C., Banks, C. E., Snyder, H. & Peeters, M., Jul 2021, In: Physica Status Solidi (A) Applications and Materials Science. 218, 13, 2100021.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Antibiotic Agent 100%
  • Molecularly Imprinted Polymer 80%
  • Antimicrobial Resistance 60%
  • Antibiotic Resistance 60%
  • Extraction 60%

• Can the Use of Serial Multiparametric Magnetic Resonance Imaging During Active Surveillance of Prostate Cancer Avoid the Need for Prostate Biopsies?-A Systematic Diagnostic Test Accuracy Review

  Hettiarachchi, D., Geraghty, R., Rice, P., Sachdeva, A., Nambiar, A., Johnson, M., Gujadhur, R., Mcneill, M., Haslam, P., Soomro, N., Zeeshan Hameed, B. M., Somani, B., Veeratterapillay, R. & Rai, B. P., 1 Jun 2021, In: European Urology Oncology. 4, 3, p. 426-436 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Multiparametric Magnetic Resonance Imaging 100%
  • Surveillance 100%
  • Systematic Review 60%
  • Disease Exacerbation 50%
  • Diagnostic Performance 50%

• Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

  COVIDSurg Collaborative, 1 Jan 2021, In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 39, 1, p. 66-78 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • COVID-19 100%
  • Patient 70%
  • Severe Acute Respiratory Syndrome Coronavirus 2 60%
  • Hospital 50%
  • Cancer Surgery 30%

• Imaging mass cytometry reveals generalised deficiency in OXPHOS complexes in Parkinson’s disease

  Chen, C., McDonald, D., Blain, A., Sachdeva, A., Bone, L., Smith, A. L. M., Warren, C., Pickett, S. J., Hudson, G., Filby, A., Vincent, A. E., Turnbull, D. M. & Reeve, A. K., 12 May 2021, In: npj Parkinson's Disease. 7, 1, p. 1-13 13 p., 39.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuron 100%
  • Parkinson's Disease 83%
  • Mass Cytometry 50%
  • Protein 33%
  • Dopaminergic 33%
  36 Downloads (Pure)

• Management of patients who opt for radical prostatectomy during the coronavirus disease 2019 (COVID‐19) pandemic: an international accelerated consensus statement

  Tandogdu, Z., Collins, J., Shaw, G., Rohn, J., Koves, B., Sachdeva, A., Ghazi, A., Haese, A., Mottrie, A., Kumar, A., Sivaraman, A., Tewari, A., Challacombe, B., Rocco, B., Giedelman, C., Wagner, C., Rogers, C. G., Murphy, D. G., Pushkar, D., Ogaya‐Pinies, G., & 22 othersPorter, J., Seetharam, K. R., Graefen, M., Orvieto, M. A., Moschovas, M. C., Schatloff, O., Wiklund, P., Coelho, R., Valero, R., Reijke, T. M., Ahlering, T., Rogers, T., Poel, H. G., Patel, V., Artibani, W., Wagenlehner, F., Maes, K., Rha, K. H., Nathan, S., Johansen, T. E. B., Hawkey, P. & Kelly, J., 10 Jun 2021, In: BJU international. 127, 6, p. 729-741 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient 100%
  • Diseases 88%
  • Prostate Cancer 88%
  • Coronavirus 66%
  • Consensus 55%

• Non‐steroidal anti‐inflammatory drugs for treating symptomatic uncomplicated urinary tract infections in non‐pregnant adult women

  Sachdeva, A., Nambiar, A., Rai, B. P., Veeratterapillay, R. & Harding, C., 18 Nov 2021, In: Cochrane Database of Systematic Reviews. 2021, 11, p. 1-11 11 p., CD014762.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Non-Steroidal Anti-Inflammatory Drug 100%
  • Urinary Tract Infection 50%
  86 Downloads (Pure)

• SDH-deficient renal cell carcinoma: a clinicopathological analysis highlighting the role of genetic counselling.

  Sachdeva, A., 1 Jan 2021, In: Annals of the Royal College of Surgeons of England. 103, 1, p. E20-E22

  Research output: Contribution to journal › Article › peer-review

  • Clear Cell Renal Cell Carcinoma 100%
  • Succinate Dehydrogenase 100%
  • Patient 66%
  • Analysis 33%
  • Development 33%

• The role of surgery in high risk and advanced prostate cancer: A narrative review

  Roy, C. S. D., Sachdeva, A., Kandaswamy, G. V. & Rai, B. P., Feb 2021, In: Turkish Journal of Urology. 47, Supp. 1, p. S56-S64

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Surgery 100%
  • Prostate Cancer 80%
  • Patient 40%
  • Therapeutic Procedure 40%
  • Toxicity 40%
• 2020

  Delaying surgery for patients with a previous SARS-CoV-2 infection

  COVIDSurg Collaborative, Edmondson, R., Owens, G. & Sachdeva, A., 25 Sep 2020, In: The British Journal of Surgery. 107, 12, p. e601-e602

  Research output: Contribution to journal › Letter › peer-review

• Lower urinary tract dysfunction in adult patients with mitochondrial disease

  Feeney, C., Gorman, G., Stefanetti, R., McFarland, R., Turnbull, D., Harding, C. & Sachdeva, A., 1 Nov 2020, In: Neurourology and Urodynamics. 39, 8, p. 2253-2263 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Lower Urinary Tract Symptom 100%
  • Disorders of Mitochondrial Functions 90%
  • Mitochondrial Disorder 90%
  • Patient 80%
  • Adult 40%
• 2018

  A novel thermal detection method based on molecularly imprinted nanoparticles as recognition elements

  Canfarotta, F., Czulak, J., Betlem, K., Sachdeva, A., Eersels, K., Grinsven, B. V., Cleij, T. J. & Peeters, M., 2018, In: Nanoscale.

  Research output: Contribution to journal › Article › peer-review

• Predominant Asymmetrical Stem Cell Fate Outcome Limits the Rate of Niche Succession in Human Colonic Crypts.

  Stamp, C., Zupanic, A., Sachdeva, A., Stoll, E. A., Shanley, D. P., Mathers, J. C., Kirkwood, T. B. L., Heer, R., Simons, B. D., Turnbull, D. M. & Greaves, L. C., 25 Apr 2018, In: EBioMedicine. p. 166-173 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Stem Cell 100%
  • Stem Cell Niche 33%
  • Cell Loss 33%
  • Oxidative Phosphorylation 33%
  • Life 16%
• 2017

  Positive surgical margins and biochemical recurrence following minimally-invasive radical prostatectomy – An analysis of outcomes from a UK tertiary referral centre

  Sachdeva, A., Veeratterapillay, R., Voysey, A., Kelly, K., Johnson, M. I., Aning, J. & Soomro, N. A., Dec 2017, In: BMC urology. 17, 91

  Research output: Contribution to journal › Article › peer-review
• 2016

  Allogeneic blood transfusion in bilateral lung transplantation: impact on early function and mortality†.

  Ong, LP., Thompson, E., Sachdeva, A., Ramesh, BC., Muse, H., Wallace, K., Parry, G. & Clark, SC., Feb 2016, In: European Journal of Cardiothoracic Surgery. 49, 2, p. 668-674 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Mortality 75%
  • Lung 62%
  • Transplantation 62%
  • Blood Product 50%

• Lung Transplant With Cardiopulmonary Bypass: Impact of Blood Transfusion on Rejection, Function, and Late Mortality.

  Ong, LP., Sachdeva, A., Ramesh, BC., Muse, H., Wallace, K., Parry, G. & Clark, SC., Feb 2016, In: Annals of Thoracic Surgery. p. 512-519 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Hazard Ratio 100%
  • Transplantation 83%
  • Erythrocyte 83%
  • Mortality 83%
  • Platelet 83%
• 2015

  Evaluating variation in use of definitive therapy and risk-adjusted prostate cancer mortality in England and the USA.

  Sachdeva, A., van, D. M. JH., Emberton, M. & Cathcart, PJ., 24 Feb 2015, In: BMJ Open. 5, 2

  Research output: Contribution to journal › Article › peer-review

  • Prostate Cancer 100%
  • Patient 37%
  • Gleason Score 37%
  • Man 25%
  • Cancer Staging 25%
• 2014

  Automated high-throughput assessment of prostate biopsy tissue using infrared spectroscopic chemical imaging

  Bassan, P., Sachdeva, A., Shanks, J. H., Brown, M. D., Clarke, N. W. & Gardner, P., 20 Mar 2014, Proc. SPIE 9041, Medical Imaging 2014: Digital Pathology, 90410D. Gurcan, M. N. & Madabhushi, A. (eds.). SPIE, p. 1-10 10 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

  • Tissues 100%
  • Procedure 100%
  • Infrared Radiation 100%
  • Chemical Imaging 75%
  • Spectra 75%

• Graduated compression stockings for prevention of deep vein thrombosis.

  Sachdeva, A., Dalton, M., Amaragiri, SV. & Lees, T., 17 Dec 2014, In: The Cochrane database of systematic reviews. 12, CD001484.

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Compression Stocking 65%
  • Deep Vein Thrombosis 50%
  • Control 15%
  • Incidence 15%
• 2013

  Substrate contributions in micro-ATR of thin samples: Implications for analysis of cells, tissue and biological fluids

  Bassan, P., Sachdeva, A., Lee, J. & Gardner, P., 21 Jul 2013, In: Analyst. 138, 14, p. 4139-4146 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Sample 100%
  • Attenuated Total Reflection 75%
  • Thickness 50%
  • Analytical Method 25%
  • Surface 25%

• The inherent problem of transflection-mode infrared spectroscopic microscopy and the ramifications for biomedical single point and imaging applications.

  Bassan, P., Lee, J., Sachdeva, A., Pissardini, J., Dorling, K. M., Fletcher, J. S., Henderson, A. & Gardner, P., 7 Jan 2013, In: Analyst. 138, 1, p. 144-157 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Sample 100%
  • Thickness 75%
  • Tissue 75%
  • Application 50%
  • Spectra 50%

• Whole organ cross-section chemical imaging using label-free mega-mosaic FTIR microscopy

  Bassan, P., Sachdeva, A., Shanks, J. H., Brown, M. D., Clarke, N. W. & Gardner, P., 7 Dec 2013, In: Analyst. 138, 23, p. 7066-7069 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tissues 100%
  • Chemical Imaging 75%
  • Evaluation Study 25%
  • Organ 25%
  • Microscopy 25%
• 2012

  FTIR microscopy of biological cells and tissue: Data analysis using resonant Mie scattering (RMieS) EMSC algorithm

  Bassan, P., Sachdeva, A., Kohler, A., Hughes, C., Henderson, A., Boyle, J., Shanks, J. H., Brown, M., Clarke, N. W. & Gardner, P., 21 Mar 2012, In: Analyst. 137, 6, p. 1370-1377 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Spectrum 100%
  • Spectra 80%
  • Tissue 60%
  • Mie Scattering 60%
  • Algorithm 60%
  189 Downloads (Pure)
• 2011

  Late outcome after repair of mitral valve rupture during balloon atrial septostomy in a neonate.

  Sachdeva, A., Bansal, RC., Bailey, LL. & Razzouk, AJ., 2011, In: Texas Heart Institute journal. 38, 4, p. 412-414 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Neonates 100%
  • Mitral Insufficiency 100%
  • Rupture 100%
  • Patient 50%
  • Age 50%
• 2010

  Elastic compression stockings for prevention of deep vein thrombosis.

  Sachdeva, A., Dalton, M., Amaragiri, S. V. & Lees, T., 7 Jul 2010, In: Cochrane database of systematic reviews (Online). 7, CD001484.

  Research output: Contribution to journal › Article › peer-review

  • Compression Stocking 100%
  • Compression 100%
  • Deep Vein Thrombosis 85%
  • Patient 85%
  • Randomized Controlled Trial 71%

• SR-FTIR spectroscopy of renal epithelial carcinoma side population cells displaying stem cell-like characteristics

  Hughes, C., Liew, M., Sachdeva, A., Bassan, P., Dumas, P., Hart, C. A., Brown, M. D., Clarke, N. W. & Gardner, P., Dec 2010, In: Analyst. 135, 12, p. 3133-3141 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cells 100%
  • Cancer Stem Cell 40%
  • Stem Cell 40%
  • Marker 40%
  • Biological Marker 40%
  96 Downloads (Pure)