James Houston, BSc, PhD, DSc

Search results

• 2013

  Drug accumulation in alveolar macrophages: assessment of uptake and lysosomal distribution in vitro.

  Houston, J., Ufuk, A., Gertz, M., Plumb, J., Somers, G. & Galetin, A., Sept 2013.

  Research output: Contribution to conference › Poster
• 2012

  In vitro assessment of accumulation of inhaled drugs by alveolar macrophages

  Houston, J., Ufuk, A., Somers, G. & Galetin, A., Sept 2012.

  Research output: Contribution to conference › Poster
• 2009

  How good is prediction of in vivo metabolic clearance from established in vitro systems?

  Foster, J., Hallifax, D. & Houston, B., 17 May 2009.

  Research output: Contribution to conference › Poster
• 2005

  Prediction of hepatic clearance from in vitro: variability and bias among human microsomes and hepatocytes.

  Hallifax, D., Griffin, M. & Houston, B., 2005.

  Research output: Contribution to conference › Poster
• 2004

  Auto- and heteroactivation of metabolism of a series of benzodiazepines in human hepatocytes.

  Hallifax, D., Rawden, H., Galetin, A., Brown, C. & Houston, J., 2004.

  Research output: Contribution to conference › Poster
• 2003

  Database analysis for drug-drug interactions involving CYP2D6 inhibition.

  Ito, K., Hallifax, D., Obach, R. S. & Houston, B., 2003.

  Research output: Contribution to conference › Poster

• Quantative prediction of CYP3A4 drug-drug interactions: extending the strategy.

  Galetin, A., Hallifax, D., Ito, K. & Houston, B., 2003.

  Research output: Contribution to conference › Poster

• Quantative prediction of drug-drug interactions: a comparison between microsomes and hepatocytes of azole-tolbutamide interactions.

  Brown, H., Hallifax, D. & Houston, B., 27 Apr 2003.

  Research output: Contribution to conference › Poster
• 2002

  Prediction of ketoconazole and fluconazole drug-drug interactions with a range of CYP3A4 substrates.

  Galetin, A., Hallifax, D., Ito, K. & Houston, B., 2002.

  Research output: Contribution to conference › Poster

• Variability of intrinsic clearance: The effect of heteroactivation by testosterone in human liver microsomes.

  Rawden, H. C., Tindall, A. J., Hallifax, D. & Houston, B., 2002.

  Research output: Contribution to conference › Poster
• 2001

  Activation and inhibition of codeine metabolism by ketoconazole and quinine in rat liver microsomes.

  Proctor, N. J., Hallifax, D., Smith, D. A. & Houston, B., 2001.

  Research output: Contribution to conference › Poster

• Heteroactivation of CYP3A4 substrates. Impact on intrinsic clearance and interindividual variability.

  Rawden, H. C., Tindall, A., Hallifax, D. & Houston, B., 2001.

  Research output: Contribution to conference › Poster
• 2000

  Quantative prediction of drug interactions: use of codeine depletion time profiles in rat microsomes and hepatocytes.

  Hallifax, D., ObachRS, [. & Houston, B., 2000.

  Research output: Contribution to conference › Poster

• Quantitiative prediction of drug interactions. Inhibition of morphine formation from codeine (CYP2D6)and substrate binding/uptake in rat microsomes and hepatocytes.

  Hallifax, D., Obach, R. S. & Houston, B., 2000.

  Research output: Contribution to conference › Poster
• 1999

  Assessment of inhibition of formation of morphine from codeine as a model for quantifying drug interactions.

  Hallifax, D. & Houston, B., 1999.

  Research output: Contribution to conference › Poster
• 1997

  Nonlinear uptake of lipophilic amine drugs into isolated rat hepatocytes: Characteristics and relationships with metabolism.

  Hallifax, D., Smith, D. A. & Houston, B., 1997.

  Research output: Contribution to conference › Poster
• 1996

  Characteristics of nonlinear uptake of lipophilic amine drugs into isolated rat hepatocytes.

  Hallifax, D., Smith, D. A. & Houston, B., Jul 1996.

  Research output: Contribution to conference › Poster