Research output per year
Research output per year
Personal profile
Qualifications
2021- Postgraduate Certificate in Higher Education (PGCertHE)
2018 - Fellow of The Higher Education Academy (FHEA)
2010 - PhD in Cell and Molecular Biology
Thesis title: “Characterisation of human breast stem/progenitor cells”
Basque Country University, CICbioGUNE, Bilbao, Spain
2004 - Graduation (equivalent to BSc + MSc) in Microbial Biology and Genetics
Faculty of Science, University of Lisbon, Portugal
Biography
I obtained my degree in Microbial Biology and Genetics at the University of Lisbon, in 2004, after completing a Research Training in Pavia (Italy).
My PhD studies were carried out in Bilbao (Spain) under the supervision of Dr Maria Vivanco and were mainly focused on analysing the effects of estrogen in human breast stem cells.
In 2011, I joined the Breast Biology group led by Professor Rob Clarke, at the University of Manchester, and since then I have been investigating the role that breast cancer stem cells play in the acquisition of endocrine therapy resistance in estrogen receptor-positive tumours.
I have also been working with Dr Sacha Howell in developing better chemoprevention approaches for women at risk of breast cancer since 2016.
Memberships of committees and professional bodies
British Association for Cancer Research (BACR)
European Association for Cancer Research (EACR)
American Association for Cancer Research (AACR)
Teaching
-
Lecturer on MSc Cancer Biology and Radiotherapy Physics course
-
Lecturer on MSc Transformative Oncology
-
Academic Advisor for Medical Students (Y1 and Y2)
-
Tutor on MRes Oncology (Tutorial Unit)
- Supervisor for Master and PhD students
- Lecturer on MSc Cell and Tissue Culture course, Autonomous University of Guerrero, Mexico
Media contributions and coverage
- Stem Cell Reports paper findings (2020)
UK media - Drug target for aggressive breast cancer found by team of UK and US scientists
- Oncogene paper findings (2020)
UK media - Novel Drug May Reverse Breast Cancer Hormone Therapy Resistance
Portuguese media - Fármaco desenvolvido para cancro da mama usa composto presente nos brócolos
Macau/China media - Drug developed to fight breast cancer uses compound found in broccoli
- Cell Reports paper findings (2015)
Portuguese media - Cientistas conseguem matar a maioria das células resistentes do cancro da mama
Activities and esteem
-
Associate Editor for Breast Cancer - Frontiers in Oncology (2021-present)
-
Guest Associate Editor for Cancer Endocrinology - Frontiers in Endocrinology (2020-present)
-
Member of the Academic Board of PhD programme in "Translational Medicine", University of Calabria, Italy (2020-present)
-
Referee of project grant applications for Prevent Breast Cancer charity, UK, and Auckland Medical Research Foundation, New Zealand (2018-present)
- Examiner of 4 PhD theses (2016-present)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Beacons, Institutes and Platforms
- Manchester Cancer Research Centre
Keywords
- Breast Biology, Breast Cancer Stem Cells, Endocrine Resistance, Breast Cancer Prevention
Fingerprint
Dive into the research topics where Bruno M Simões is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Editorial: Adipokines and hormone-dependent cancers
Andò, S. & Simões, B. M., 1 Dec 2023, In: Frontiers in Endocrinology. 14, 1340171.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Sex steroid hormones: effects on breast cancer risk and etiology
Mousa, N. A., Marino, N. & Simões, B. M., 19 Apr 2023, (E-pub ahead of print) In: Frontiers in Endocrinology. 14, 1198770.Research output: Contribution to journal › Editorial › peer-review
Open Access -
Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Bartlett, T. E., Evans, I., Jones, A., Barrett, J. E., Haran, S., Reisel, D., Papaikonomou, K., Jones, L., Herzog, C., Pashayan, N., Simões, B. M., Clarke, R. B., Evans, D. G., Ghezelayagh, T. S., Ponandai-Srinivasan, S., Boggavarapu, N. R., Lalitkumar, P. G., Howell, S. J., Risques, R. A. & Rådestad, A. F. & 3 others, , 15 Jun 2022, In: Genome Medicine. 14, 1, p. 64 64.Research output: Contribution to journal › Article › peer-review
Open Access -
Correction: Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Bartlett, T. E., Evans, I., Jones, A., Barrett, J. E., Haran, S., Reisel, D., Papaikonomou, K., Herzog, C., Pashayan, N., Simões, B. M., Evans, D. G., Ghezelayagh, T. S., Ponandai-Srinivasan, S., Boggavarapu, N. R., Lalitkumar, P. G., Howell, S. J., Risques, R. A., Rådestad, A. F., Dubeau, L. & Gemzell-Danielsson, K. & 1 others, , 19 Jul 2022, In: Genome Medicine. 14, 1, p. 76Research output: Contribution to journal › Article
-
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
Bach, K., Pensa, S., Zarocsinceva, M., Kania, K., Stockis, J., Pinaud, S., Lazarus, K. A., Shehata, M., Simões, B. M., Greenhalgh, A. R., Howell, S. J., Clarke, R. B., Caldas, C., Halim, T. Y. F., Marioni, J. C. & Khaled, W. T., 9 Mar 2021, In: Nature Communications. 12, 1Research output: Contribution to journal › Article › peer-review
Open Access
Impacts
-
Drug target for aggressive breast cancer found
Bruno M Simões (Participant)
Impact: Health and wellbeing