Research output per year
Research output per year
- 32 results
Search results
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2022
Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Bartlett, T. E., Evans, I., Jones, A., Barrett, J. E., Haran, S., Reisel, D., Papaikonomou, K., Jones, L., Herzog, C., Pashayan, N., Simões, B. M., Clarke, R. B., Evans, D. G., Ghezelayagh, T. S., Ponandai-Srinivasan, S., Boggavarapu, N. R., Lalitkumar, P. G., Howell, S. J., Risques, R. A. & Rådestad, A. F. & 3 others, , 15 Jun 2022, In: Genome Medicine. 14, 1, p. 64 64.Research output: Contribution to journal › Article › peer-review
Open Access -
Correction: Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
Bartlett, T. E., Evans, I., Jones, A., Barrett, J. E., Haran, S., Reisel, D., Papaikonomou, K., Herzog, C., Pashayan, N., Simões, B. M., Evans, D. G., Ghezelayagh, T. S., Ponandai-Srinivasan, S., Boggavarapu, N. R., Lalitkumar, P. G., Howell, S. J., Risques, R. A., Rådestad, A. F., Dubeau, L. & Gemzell-Danielsson, K. & 1 others, , 19 Jul 2022, In: Genome Medicine. 14, 1, p. 76Research output: Contribution to journal › Article
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2021
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors
Bach, K., Pensa, S., Zarocsinceva, M., Kania, K., Stockis, J., Pinaud, S., Lazarus, K. A., Shehata, M., Simões, B. M., Greenhalgh, A. R., Howell, S. J., Clarke, R. B., Caldas, C., Halim, T. Y. F., Marioni, J. C. & Khaled, W. T., 9 Mar 2021, In: Nature Communications. 12, 1Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Increased expression of interleukin-1 receptor characterizes anti-estrogen resistant ALDH+ breast cancer stem cells
Sarmiento Castro, A., Caamaño-Gutiérrez, E., Sims, A. H., Hull, N., James, M., Santiago-Gómez, A., Eyre, R., Clark, C., Brown, M. E., Brooks, M. D., Hayes, D. F., Wicha, M. S., Howell, S., Clarke, R. & M Simoes, B., 11 Aug 2020, In: Stem Cell Reports. 15, 2, p. 307-316 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells
Lazaro-Carrillo, A., Calero, M., Aires, A., L Cortajarena, A., Simões, B. M., Latorre, A., Somoza, Á., Clarke, R. B., Miranda, R. & Villanueva, A., 29 May 2020, In: Cancers. 12, 6Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer
M Simoes, B., Santiago-Gómez, A., Chiodo, C., Moreira, T., Conole, D., Lovell, S., Alferez-Castro, D., Eyre, R., Spence, K., Sarmiento Castro, A., Kohler, B., Morisset, L., Lanzino, M., Ando, S., Marangoni, E., Sims, A. H., Tate, E., Howell, S. & Clarke, R., 18 Jun 2020, In: Oncogene. 39, 25, p. 4896–4908 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells
Domenici, G., Aurrekoetxea-Rodríguez, I., Simões, B. M., Rábano, M., Lee, S. Y., Millán, J. S., Comaills, V., Oliemuller, E., López-Ruiz, J. A., Zabalza, I., Howard, B. A., Kypta, R. M. & Vivanco, M. D., 2019, In: Oncogene.Research output: Contribution to journal › Article › peer-review
Open Access -
FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4
McClements, L., Annett, S., Yakkundi, A., O'Rourke, M., Valentine, A., Moustafa, N., Alqudah, A., Simões, B. M., Furlong, F., Short, A., McIntosh, S. A., McCarthy, H. O., Clarke, R. B. & Robson, T., 2019, In: BMC Cancer. 19, 1, 351.Research output: Contribution to journal › Article › peer-review
Open Access -
Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
Eyre, R., Alferez-Castro, D., Santiago-Gómez, A., Spence, K., Mcconnell, J., Hart, C., M Simoes, B., Lefley, D., Tulotta, C., Storer, J., Gurney, A., Clarke, N., Brown, M., Howell, S., Sims, A. H., Farnie, G., Ottewell, P. D. & Clarke, R. B., 1 Nov 2019, In: Nature Communications. 10, 1, p. 5016 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
PAK4 regulates stemness and progression in endocrine resistant ERpositive metastatic breast cancer
Santiago-Gómez, A., Kedward, T., M Simoes, B., Dragoni, I., NicAmhlaoibh, R., Trivier, E., Sabin, V., Gee, J. M., Sims, A. H., Howell, S. J. & Clarke, R. B., 28 Aug 2019, In: Cancer Letters. 11 p., 10.1016/j.canlet.2019.05.014.Research output: Contribution to journal › Article › peer-review
Open Access -
Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer
Bacci, M., Lorito, N., Ippolito, L., Ramazzotti, M., Luti, S., Romagnoli, S., Parri, M., Bianchini, F., Cappellesso, F., Virga, F., Gao, Q., M Simoes, B., Marangoni, E., Martin, L.-A., Comito, G., Ferracin, M., Giannoni, E., Mazzone, M., Chiarugi, P. & Morandi, A., 2 Jul 2019, In: Cell Reports. 28, 1, p. 104-118Research output: Contribution to journal › Article › peer-review
Open Access -
The Notch Pathway Promotes Osteosarcoma Progression through Activation of Ephrin Reverse Signaling
Yu, L., Xia, K., Gao, T., Chen, J., Zhang, Z., Sun, X., Simões, B. M., Eyre, R., Fan, Z., Guo, W. & Clarke, R. B., 1 Dec 2019, In: Molecular Cancer Research. 17, 12, p. 2383-2394 12 p.Research output: Contribution to journal › Article › peer-review
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2018
Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP
Piggott, L., Silva, A., Robinson, T., Santiago-Gómez, A., Simões, B. M., Becker, M., Fichtner, I., Andera, L., Young, P., Morris, C., Barrett-Lee, P., Alchami, F., Piva, M., Vivanco, M. D., Clarke, R. B., Gee, J. & Clarkson, R., 15 May 2018, In: Clinical Cancer Research. 24, 10, p. 2452-2463 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors
M Simoes, B., Kohler, B., Clarke, R. B., Stringer, J., Novak Frazer, L., Young, K., Richardson, R., Zucchini, G., Armstrong, A. & Howell, S., 2018, In: Therapeutic Advances in Medical Oncology. 10Research output: Contribution to journal › Article › peer-review
Open Access -
Ethnicity influences breast cancer stem cells' drug resistance
Kamal, M., Nafie, E. H. O., Elsers, S., Alanwar, S., Ibrahim, R., Farag, F., Mlees, M., Simões, B. M., Spence, K., Santiago-Gómez, A., Salem, M. L. & Clarke, R. B., Jul 2018, In: Breast Journal. 24, 4, p. 701-703 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile188 Downloads (Pure) -
The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells
Alferez-Castro, D., M Simoes, B., Howell, S. & Clarke, R., 2018, In: Current Stem Cell Reports.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
A Role for Notch Signalling in Breast Cancer and Endocrine Resistance.
Acar, A., Simões, B. M., Clarke, R. B. & Brennan, K., 2016, In: Stem cells international. 2016Research output: Contribution to journal › Article › peer-review
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Cisplatin selects for stem-like cells in osteosarcoma by activating notch signaling
Yu, L., Fan, Z., Fang, S., Yang, J., Gao, T., Simões, B. M., Eyre, R., Guo, W. & Clarke, R. B., 20 Apr 2016, In: Oncotarget.Research output: Contribution to journal › Article › peer-review
Open Access -
Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity.
Giordano, C., Chemi, F., Panza, S., Bonofiglio, D., Lanzino, M., Cordella, A., Campana, A., Hashim, A., Rizza, P., Győrffy, B., Simões, B. M., Clarke, R., Weisz, A., Catalano, S. & Andò, S., 12 Jan 2016, In: Oncotarget. 7, 2, p. 1262-1275 13 p.Research output: Contribution to journal › Article › peer-review
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Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells.
Aires, A., Ocampo, S. M., Simões, B. M., Josefa Rodríguez, M., Couleaud, P., Spence, K., Latorre, A., Miranda, R., Somoza, Á., Clarke, R., Carrascosa, J. L. & Cortajarena, A. L., 12 Feb 2016, In: Nanotechnology. 27, 6, p. 065103Research output: Contribution to journal › Article › peer-review
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Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis
Eyre, R., Alférez, D. G., Spence, K., Kamal, M., Shaw, F. L., Simões, B. M., Santiago-Gómez, A., Sarmiento-Castro, A., Bramley, M., Absar, M., Saad, Z., Chatterjee, S., Kirwan, C., Gandhi, A., Armstrong, A. C., Wardley, A. M., O'Brien, C. S., Farnie, G., Howell, S. J. & Clarke, R. B., 28 Sept 2016, In: Journal of Mammary Gland Biology and Neoplasia.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
M Simoes, B., O'Brien, C., Eyre, R., Silva, A., Yu, L., Sarmiento Castro, A., Alferez-Castro, D., Spence, K., Santiago-Gomez, A., Chemi, F., Acar, A., Gandhi, A., Howell, A., Brennan, K., Rydén, L., Catalano, S., Andó, S., Gee, J., Ucar, A. & Sims, A. H. & 5 others, , 29 Sept 2015, In: Cell Reports. 12, 12, p. 1968-1977 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile143 Downloads (Pure) -
The role of steroid hormones in breast cancer stem cells
Simões, B. M., Alferez, D., Howell, S. & Clarke, R., 17 Sept 2015, In: Endocrine-related cancer. 22 (6):T177-86, 6, p. 177-186 9 p., ERC-15-0350.Research output: Contribution to journal › Article › peer-review
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2014
Sox2 promotes tamoxifen resistance in breast cancer cells
Piva, M., Domenici, G., Iriondo, O., Rábano, M., Simões, B. M., Comaills, V., Barredo, I., López-Ruiz, J. A., Zabalza, I., Kypta, R. & Vivanco, M. D. M., Jan 2014, In: EMBO Molecular Medicine . 6, 1, p. 66-79 13 p.Research output: Contribution to journal › Article › peer-review
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2013
Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity
Yu, L., Liu, S., Zhang, C., Zhang, B., Simões, B. M., Eyre, R., Liang, Y., Yan, H., Wu, Z., Guo, W. & Clarke, R., Dec 2013, In: Oncotarget. 4, 12, p. 2326-2338 12 p.Research output: Contribution to journal › Article › peer-review
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Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling
Harrison, H., Simões, B. M., Rogerson, L., Howell, S. J., Landberg, G. & Clarke, R. B., 8 Mar 2013, In: Breast Cancer Research. 15, 2, R21.Research output: Contribution to journal › Article › peer-review
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Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells
Singh, J. K., Simoes, B. M., Howell, S. J., Farnie, G. & Clarke, R. B., 30 Aug 2013, In: Breast Cancer Research. 15, 4, p. 1-9 9 p., 210.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and -independent mechanisms.
Singh, J. K., Farnie, G., Bundred, N. J., Simões, B. M., Shergill, A., Landberg, G., Howell, S. J. & Clarke, R. B., 1 Feb 2013, In: Clinical cancer research : an official journal of the American Association for Cancer Research. 19, 3, p. 643-656 13 p.Research output: Contribution to journal › Article › peer-review
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Targeting IL-8 signalling to inhibit breast cancer stem cell activity
Singh, J. K., Simões, B. M., Clarke, R. B. & Bundred, N. J., Nov 2013, In: Expert Opinion on Therapeutic Targets. 17, 11, p. 1235-1241 6 p.Research output: Contribution to journal › Article › peer-review
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2012
A detailed mammosphere assay protocol for the quantification of breast stem cell activity
Shaw, F. L., Harrison, H., Spence, K., Ablett, M. P., Simões, B. M., Farnie, G. & Clarke, R. B., Jun 2012, In: Journal of Mammary Gland Biology and Neoplasia. 17, 2, p. 111-117 6 p.Research output: Contribution to journal › Article › peer-review
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2011
Cancer stem cells in the human mammary gland and regulation of their differentiation by estrogen
Simões, B. M. & Vivanco, M. D., Aug 2011, In: Future Oncology. 7, 8, p. 995-1006 11 p.Research output: Contribution to journal › Article › peer-review
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Effects of estrogen on the proportion of stem cells in the breast
Simões, B. M., Piva, M., Iriondo, O., Comaills, V., López-Ruiz, J. A., Zabalza, I., Mieza, J. A., Acinas, O. & Vivanco, M. D. M., Aug 2011, In: Breast Cancer Research and Treatment. 129, 1, p. 23-35 12 p.Research output: Contribution to journal › Article › peer-review