Research output per year
Research output per year
Personal profile
Overview
Wellcome Early-Career Fellow in Chemical Biology / FBMH / Division of Pharmacy & Optometry
My research uses selection methods including mRNA display and DNA-encoded libraries and innovative chemical biology tools to identify novel ligands for challenging protein targets. These ligands can be used as starting points for drug discovery, or as chemical probes to better understand biological pathways.
My research focusses on adapting these selection methods to native cellular environments, enabling access to membrane protein targets and large protein complexes. This will accelerate the discovery of high-quality chemical probes and give access to new protein targets.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Science, Development of stapled peptides targeting the Ral GTPases, University of Cambridge
1 Oct 2016 → 30 Sept 2020
Award Date: 30 Sept 2020
Master in Science, Medicinal and Biological Chemistry (MSci), University of Nottingham
1 Sept 2012 → 30 Aug 2016
Areas of expertise
- QD Chemistry
- Chemical Biology
- Peptides
- Macrocycles
- mRNA display
- DNA-encoded libraries
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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mRNA display in cell lysates enables identification of cyclic peptides targeting the BRD3 extraterminal domain
Hurd, C. A., Bush, J. T., Powell, A. J. & Walport, L. J., 20 Mar 2024, Cold Spring Harbor Laboratory Press, (bioRxiv).Research output: Preprint/Working paper › Preprint
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mRNA Display in Cell Lysates Enables Identification of Cyclic Peptides Targeting the BRD3 Extraterminal Domain
Hurd, C. A., Bush, J. T., Powell, A. J. & Walport, L. J., 16 Sept 2024, In: Angewandte Chemie.Research output: Contribution to journal › Article › peer-review
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The FAM13A Long Isoform Regulates Cilia Movement and Co-ordination in Airway Mucociliary Transport
Howes, A., Rogerson, C., Belyaev, N., Karagyozova, T., Rapiteanu, R., Fradique, R., Pellicciotta, N., Mayhew, D., Hurd, C., Crotta, S., Singh, T., Dingwell, K., Myatt, A., Arad, N., Hasan, H., Bijlsma, H., Panjwani, A., Vijayan, V., Young, G. & Bridges, A. & 9 others, , 1 May 2024, (E-pub ahead of print) In: American Journal of Respiratory Cell and Molecular Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of photocrosslinking peptide ligands by mRNA display
Wu, Y., Bertran, M. T., Joshi, D., Maslen, S. L., Hurd, C. & Walport, L. J., 31 May 2023, In: Communications Chemistry. 6, 1, 103.Research output: Contribution to journal › Article › peer-review
Open Access -
Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases
Hurd, C. A. & Brear, P., 19 Jan 2021, In: Journal of Biological Chemistry.Research output: Contribution to journal › Article › peer-review